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Polymerase chain reaction (PCR) is a chemical reaction harnessed to detect and identify trace bits of DNA, whether from a virus or bacteria. It have limited value in diagnosing an infection. It has great value for forensic examination in criminal justice and archaeology. It involves certain number of cycles of amplification of genetic material (this number of called Cr -- the last two letter of the test abbreviation) and this number of critical for determining the validity of the case. As a reminder, "cycle thresholds" (Ct) are the level at which widely used polymerase chain reaction (PCR) test can detect a sample of the COVID-19 virus. The higher the number of cycles, the lower the amount of viral load in the sample; the lower the cycles, the more prevalent the virus was in the original sample. Here is one comment from ZeroHedge
It beggars belief that governments have rarely specified to their health agencies what level of amplification cycles (Ct) should be used when carrying out PCR tests given its known inappropriateness for detecting CovID-19.
Also, the NY Slimes article from last year refers to 30 Ct, but more recently the figure of 17-24 cycles has been quoted as appropriate to produce the best result. Above that it goes haywire.
Further, Kary Mullis is on video clearly stating that his PCR test cannot detect any live virus and was never developed to do that. All it detects is assorted debris and fragments in the human body left over from earlier flu viruses etc.
Unfortunately medical charlatans like Fauci ignored this this metric creating what is called "casedemic". Facts now suggest that number of amplification used in the USA (40) was too high and created a lot of false positives (noise from excessive amplification, much like noise when you attempt to amplify very weak sound from mike using electronic amplifier). Looks like WHO "group of experts" recommended such an excessive number of amplifications, and this is where it gets interesting as WHO by-and-large is controlled by Big Pharma. In the USA the situation was aggravated because Cr number was not reported with the test -- suggesting large scale scam and unnecessary hardships inflicted on the population.
That has several consequences outlined by John Hunt, MD who is a pediatric pulmonologist/allergist/immunologist, in COVID Gone Crazy - An Epidemic Of 'Positive' Tests (Jan 11, 2021 ):
- We have an epidemic of COVID-positive tests that is substantially larger than the epidemic of identified Relevant Infectious COVID Disease. In contrast, people with actual, mild cases of COVID-disease aren’t all getting tested. So the data, on which lockdowns are supposedly justified, are lousy.
- The data on COVID hospitalizations and deaths in the US are exaggerated by a government subsidization scheme that incentivizes the improper use of tests in people without particular risk of the disease.
- Avoid getting tested for COVID unless you are symptomatic yourself, have had exposure to someone who was both symptomatic and tested positive for COVID, or have some other personal reason that makes sense.
- Know that getting tested before traveling abroad puts you at a modest risk of getting a false-positive test result, which will assuredly screw up your trip. It’s a new political risk of travel.
- There is a lot more to this viral testing game, and there are a lot of weird incentives. There are gray areas and room for debate.
- Yes, the COVID disease can kill people. But a positive test won’t kill anybody. Sadly, every COVID-positive test empowers those politicians and bureaucrats who have a natural bent to control people — the sociopaths and their ilk.
This test became standard for detecting the presence of the SARS CoV-2 coronavirus and is responsible for tremendously inflated numbers of infected people (aka casedemic). When we see reports of cases of COVID-19 rising, we should know that they are defining “case” as anyone with a COVID-19-positive test, which, as you might now realize, is really a garbage number. See for example, discussion at For The First Time, A US State Will Require Disclosure Of PCR 'Cycle Threshold' Data In COVID Tests - Zero Hedge
We have detailed the controversy surrounding America's COVID "casedemic" and the misleading results of the PCR test and its amplification procedure in great detail over the past few months.
As a reminder, "cycle thresholds" (Ct) are the level at which widely used polymerase chain reaction (PCR) test can detect a sample of the COVID-19 virus. The higher the number of cycles, the lower the amount of viral load in the sample; the lower the cycles, the more prevalent the virus was in the original sample.
Numerous epidemiological experts have argued that cycle thresholds are an important metric by which patients, the public, and policymakers can make more informed decisions about how infectious and/or sick an individual with a positive COVID-19 test might be. However, as JustTheNews reports, health departments across the country are failing to collect that data .
Here are a few headlines from those experts and scientific studies:
2. The Wadworth Center, a New York State laboratory, analyzed the results of its July tests at the request of the NYT: 794 positive tests with a Ct of 40: " With a Ct threshold of 35 , approximately half of these PCR tests would no longer be considered positive ," said the NYT. "And about 70% would no longer be considered positive with a Ct of 30! "
3. An appeals court in Portugal has ruled that the PCR process is not a reliable test for Sars-Cov-2 , and therefore any enforced quarantine based on those test results is unlawful.
4. A new study from the Infectious Diseases Society of America , found that at 25 cycles of amplification, 70% of PCR test "positives" are not "cases" since the virus cannot be cultured, it's dead. And by 35: 97% of the positives are non-clinical.
5. PCR is not testing for disease, it's testing for a specific RNA pattern and this is the key pivot. When you crank it up to 25, 70% of the positive results are not really "positives" in any clinical sense , since it cannot make you or anyone else sick
So, in summary, with regard to our current "casedemic", positive tests as they are counted today do not indicate a "case" of anything. They indicate that viral RNA was found in a nasal swab. It may be enough to make you sick, but according to the New York Times and their experts, probably won't.
And certainly not sufficient replication of the virus to make anyone else sick. But you will be sent home for ten days anyway, even if you never have a sniffle. And this is the number the media breathlessly reports... and is used to fearmonger mask mandates and lockdowns nationwide...
PCR is a technique that is used to amplify trace amounts of DNA (and in some instances, RNA) located in or on almost any liquid or surface where DNA strands may be deposited. The key to understanding PCR is to know that every human, animal, plant, parasite, bacterium, or virus contains genetic material such as DNA (or RNA) sequences (nucleotide sequences or pieces of DNA or RNA) that are unique to their species, and to the individual member of that species. Consequently, if a sample contains segments of DNA or RNA, PCR is a method used to amplify (make many more identical copies) of these unique sequences so they can then be used to determine with a very high probability the identity of the source (a specific person, animal, or pathogenic organism) of the trace DNA or RNA found in or on almost any sample of material. And this amplification number is critical as noise increases with the number of amplification. Anything about 30 is suspect, but anything below 20 probably indicate that you are infected. The interval from 20 to 30 is a grey zone.
The test was widely abused making 40 amplifications which inflated the number of infected people and introduced huge economic losses.
PCR amplification is only part of the identifying test, however. Once the amplification is done (see below), the amplified segments need to be compared to other nucleotide segments from a known source (for example, a specific person, animal, or pathogenic organism). This comparison of unique segments is often done by placing PCR-generated nucleotide sequences next to known nucleotide sequences from humans, pathogens, or other sources in a separating gel. Electrical current is run through the gel and the various nucleotide sequences form bands that resemble a "ladder" according to their electrical charge and molecular size. This is termed gel electrophoresis. Bands or "ladder" like steps that migrate to the same levels in the gel show identity of nucleotide sequences. This method is one of the most popular ways PCR tests are completed
The test was invented in 1983 by Kary Mullis, who figured out the basic steps to amplify DNA sequences. He and Michael Smith were awarded the Nobel Prize for developing this procedure in 1993. There are a few basic steps that are followed in sequence:
PCR can be done in a single tube with appropriate chemicals and a specially designed heater. The reagents or chemicals needed are as follows: A sample that contains a nucleotide sequence (from blood, hair, pus, skin scraping, etc.) DNA primers: short single-stranded DNA that attaches to nucleotide sequences that promotes synthesis of a complementary strand of nucleotides DNA polymerase: an enzyme that, when the DNA has a primer bound, goes down the DNA segment attaching DNA building blocks to form complementary base pairs and thus synthesizes a complementary nucleotide strand of DNA (the introduction of a heat-resistant DNA polymerase, Taq polymerase, derived from heat-resistant bacteria, markedly improved the ability to perform PCR)
A large excess of DNA building blocks termed nucleotides (Adenine, Thymidine, Cytosine, and Guanine, abbreviated as: A, T, C, and G, respectively) are present in the solution. When these blocks are linked together, they form a nucleotide sequence or a single strand of DNA. When these building blocks bind their complementary building block by weak hydrogen bonds (for example, A will only bond with T and G only with C) a complementary DNA nucleotide sequence is formed and bound to the original single-stranded DNA. When the binding is completed, a complementary double strand DNA is formed in a specific sequence.
PCR, then, begins with a segment of DNA from a sample that is placed in a tube with the reagents listed above. The solution is heated to at least 94 C (201.2 F); this heat breaks the hydrogen bonds that allow complementary DNA strands to form, so only single strands exist in the mixture (this is termed denaturation of double-stranded DNA).
The mixture is allowed to cool to about 54 C (129.2 F). At this temperature, the DNA primers and DNA polymerase bind to individual single-stranded DNA (this is termed annealing of the DNA). Because the building blocks are in excess (high concentration) in the mixture, the polymerase uses them to make new complementary strands of DNA (termed extension of the DNA) and this process is more rapid at 72 C (161.6 F). This process creates a new double-stranded DNA molecule from each of the single strands of the original molecule.
This cycle is repeated about 40 times in a machine termed a thermal cycler that automatically repeats the heating-cooling cycles, with the amount of each DNA sequence doubling each time the heating-cooling cycle is completed.
What initially was a single short segment of DNA can be amplified to about 100 billion copies after 40 doubling cycles.
The PCR test forms the basis of a number of tests that can answer many different medical questions that help physicians diagnose and treat patients. For example, PCR tests can detect and identify pathogenic organisms in patients, especially those that are difficult to cultivate (for example, HIV and other viruses and certain fungi).
Although initial PCR tests amplified DNA, many viruses and other biological components (for example, mitochondria) utilize RNA as their genetic material.
RT-PCR differs from conventional PCR by first taking RNA and converting the RNA strand into a DNA strand. This is done by essentially the same method for PCR described above with the exception of using an enzyme termed reverse transcriptase instead of the DNA polymerase. The reverse transcriptase allows a single strand of RNA to be translated into a complementary strand of DNA. Once that reaction occurs, the routine PCR method can then be used to amplify the DNA. RT-PCR has been used to detect and study many RNA viruses. RT-PCR should not be confused with another variation of PCR, termed Real-Time PCR.
Real-Time PCR is a variation of PCR that allows analysis of the amplified DNA during the usual 40 cycles of the procedure. Although the procedure is similar to conventional PCR with cycling, Real-Time PCR uses fluorescent dyes attached to some of the building blocks or small nucleotide strands. Depending on the method used, fluorescence occurs when the amplified DNA strands are formed. The amount of fluorescence can be measured throughout the 40 cycles and allows the investigators to measure specific products and their amounts during the amplification cycles. This often allows investigators or lab technicians to skip the gel electrophoresis or other secondary procedures needed for analysis of the PCR products, thus producing more rapid results.
Real-Time PCR and RT-PCR are variations or modifications of the original PCR test. However, there are many more variations (at least 25) that exist and are used to solve specific problems. They all have different names such as Assembly PCR, Hot-start PCR, Multiplex PCR, Solid-phase PCR and many others.
PCR is likely to continue to be modified to help answer any other questions in medicine, biology. and other fields of study.
It’s simple, a massive increase in cases was a direct result of a massive increase in testing.
It all started on Jan 10th 2020, when WHO reported that there is an outbreak in China caused by a novel coronavirus.
On Jan 17th 2020, The WHO recommended the use of the Corman-Drosten PCR test as a gold standard for detecting SARS-Cov-2 before the paper was even submitted for publishing.
On Jan 21 2020, the Corman-Drosten paper was submitted to the scientific journal Eurosurveillance describing the PCR test.On Jan 22 2020, it was accepted for publication.
On Jan 23rd 2020, it was published.Keep in mind that at the point when they started working on the PCR test, the genetic material of the virus was not yet sequenced.
“We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available.”
“The PCR test was therefore designed using the genomic sequence of SARS-CoV” “Design and validation were enabled by the close genetic relatedness to the 2003 SARS-CoV.”
Listen to Kevin_McKernan @ 10:37 he estimates that they started working on the PCR test at least 2 months prior to the publication of the paper, so towards the end of Nov 2019.
“You have to recognise the body of the work that they presented is not something you can do in a week that looks like maybe 2 months worth of work, which of course begs the question of who tipped them off to making this, early, prior to actually being a pandemic.
The paper was not peer-reviewed. It was approved in one day. It takes on average 179 days to peer review an article.
Conflict of interest was not declared: a) Drosten and his co-author Dr Chantal Reusken happen to be members of the editorial board of Eurosurveillance.
Olfert Landt, of Tib-Molbiol, the company that developed the PCR test being used, was also a co-author of the Drosten paper. “they distributed these PCR-test kits before the publication was even submitted.” They were already in business before the pandemic started.
In March 2020, the pandemic happened. The more we tested, the more cases we got, the more we assigned any death with a positive test to COVID19.
The world went into lockdown based on a fear of rising cases, asymptomatic transmission, widespread susceptibility, lack of pre-existing immunity, & lack of acquired immunity after Covid, with complete disregard to the fact that 80% of cases had no symptoms or mild symptoms and that mortality followed an age gradient. All these fears were not justified and contradicted our accumulated scientific knowledge. Basic immunological facts were put to question to disinform and confuse the innocent public.
Countries adopted an umbrella approach despite the fact that the profile of the vulnerable population was very clear since March 2020: older individuals with multiple comorbidities were at high risk of developing serious disease that could culminate in a negative outcome.
In June 2020, the casedemic happened. As the prevalence of C19 decreased & herd
immunity approached, we started to tally up false (+) ‘cases’. The test was more likely to detect viral debris at this point than an infectious virus, especially with cycle thresholds above 30.The WHO & Corman-Drosten protocol recommended a Ct of 45 cycles. Studies that conducted viral culture showed that with a PCR test Ct >30, the tests were not detecting an infectious virus anymore. Yet governments turned a blind eye to these findings & never revised
their Ct.On the 27th of November 2020, 23 scientists finally reviewed the Corman- Drosten paper and have demanded it’s retraction.
Go here:
https://cormandrostenreview.com/report/
The whole affair stinks to high heaven IMO.
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Jul 01, 2021 | www.zerohedge.com
Hipneck911 11 minutes ago
Hipneck911 10 minutes ago... NSW Health - Covid PCR tests at 40 cycles, double the ...
← Craig Kelly MP a true Australian hero warns there could have been 50,000 deaths from Covid vax. NSW Health - Covid PCR tests at 40 cycles , double the recommended rate yielding 80 per cent false positives* Jun 28. Posted by Editor, cairnsnews. Letter to the Editor.
You gutless losers sure do like lying:
Up to 90 percent of people tested for COVID-19 in Massachusetts, New York and Nevada in July carried barely any traces of the virus and it could be because today's tests are 'too sensitive', experts say.
... PCR tests analyze genetic matter from the virus in cycles and today's tests typically take 37 or 40 cycles, but experts say this is too high because it detects very small amounts of the virus that don't pose a risk.
Experts say a reasonable cutoff for the virus would be 30 or 35 cycles, according to Juliet Morrison, a virologist at the University of California, Riverside.
Mina said he would set the cutoff at 30.
New York's state lab Wadsworth analyzed cycle thresholds values in already processed COVID-19 PCR tests and found in July that 794 positive tests were based on a threshold of 40 cycles.
With a cutoff of 35, about half of those tests would no longer qualify as positive. About 70 percent would no longer be judged positive if the cycles were limited to 30.
In Massachusetts, from 85 to 90 percent of people who tested positive in July with a cycle threshold of 40 would have been considered negative if the threshold were 30 cycles, Mina said.
Aug 30, 2020 | www.msn.com
Marlene Lenthang For Dailymail.com 8/30/2020
Up to 90 percent of people tested for COVID-19 in Massachusetts, New York and Nevada in July carried barely any traces of the virus and it could be because today's tests are 'too sensitive', experts say.
... PCR tests analyze genetic matter from the virus in cycles and today's tests typically take 37 or 40 cycles, but experts say this is too high because it detects very small amounts of the virus that don't pose a risk.
... ... ...
Experts say a reasonable cutoff for the virus would be 30 or 35 cycles, according to Juliet Morrison, a virologist at the University of California, Riverside.
Mina said he would set the cutoff at 30.
New York's state lab Wadsworth analyzed cycle thresholds values in already processed COVID-19 PCR tests and found in July that 794 positive tests were based on a threshold of 40 cycles.
With a cutoff of 35, about half of those tests would no longer qualify as positive. About 70 percent would no longer be judged positive if the cycles were limited to 30.
In Massachusetts, from 85 to 90 percent of people who tested positive in July with a cycle threshold of 40 would have been considered negative if the threshold were 30 cycles, Mina said.
'I would say that none of those people should be contact-traced, not one,' he said.
The Food and Drug Administration said that it does not specify the cycle threshold ranges used to determine who is positive and 'commercial manufacturers and laboratories set their own.'
The Centers for Disease Control and Prevention said it is examining the use of cycle threshold measures for 'policy decision'.
The CDC said its own calculations suggest its extremely hard to detect a live virus in a sample above a threshold of 33 cycles.
It's just kind of mind-blowing to me that people are not recording the C.T. values from all these tests -- that they're just returning a positive or a negative,' Angela Rasmussen, a virologist at Columbia University in New York, said.
May 22, 2021 | www.zerohedge.com
31 play_arrow 1
sgpbulion 7 hours ago
Dr Phuckit 16 hours ago remove linkCycle testing - running the same test over and over unitl you get the results you want and then stopping.
Believe it or not this is the same foolishness that goes into radiometric dating of how old rocks are. It's why you can take a warm chunk of lava and send it in to the dating lab and get a result of over 25 million years old.
Trust the science folks - resistance is futile
By the way if the test shows negative after 30 cycles - it means that there is not enough virus in your system for it be dangerous and that your body can deal with it on its own. By the time you get to 35 cycles it is amplified so much that it will show any virus fragment in your system - and at such miniscule amounts that the body does not even know its there - and its not a problem. When you get 40 cycles and above the test will have to be positive because there is always some virus fragments in your system. The single fact that they can run +40 cycles and get a negative result shows that this test is actually garbage from the start.
Dr Phuckit 15 hours agoMy own interpretation of Government Data, tells me anything above 25 cycles is fraudulent.
It looks like the CDC has come to their senses, but still bordering towards fraudulent data.
At 30 cycles it's 50/50 chance of being right. But right for what exactly because it still can't detect a virus, can't determine if it was a new infection or an old infection not even active. Above 40+ even a rock will test positive.
What all this has accomplished though, is Corporations now have DNA samples of most of worlds population , and these F'wits that weren't sick couldn't opt-in fast enough. Imagine if these Corporations had said, we want your DNA for our Database, how many would have volunteered ?
These Corporations now have the capability to target specific people with DNA for any evil purpose they might have in the future. Perhaps this was the plan all along, DNA collection.
shakypudding 16 hours ago remove linkThe CDC can't stop the flood of lawsuits about to unfold, they are now trying to minimize the damage to it's control and bank account. And the CDC is nothing but an interface between All Pharmaceutical Companies and Government. They have no real power to mandate anything, all they can do is recommend because it's about as Federal as the Federal Reserve.
InfiniteIntellRules 10 hours ago remove linkThe rt-CPR tests were sanctioned per emergency use authorizations (EUA) which means no prior certification of efficacy. This rendered the lab results useless except for propaganda.
The vaccines were also issued per emergency use authorization (EUA) which means no prior certification of efficacy. How and why can this happen? Emergency use authorizations are permitted when alternative treatments are not officially recognized, such as HCQ, Ivermectin and vitamin D.
Had the government sanctioned alternative treatments such as HCQ, Ivermectin and vitamin D millions of drug company profits and government kickbacks would have been forfeited.
Additionally, the opportunity for extending social programs of conditioning and control would have been forgone by your overlords.
WHO sued over fake PCR test...
May 22, 2021 | www.zerohedge.com
Authored by Kit Knightly via Off-Guardian.org,
New policies will artificially deflate "breakthrough infections" in the vaccinated, while the old rules continue to inflate case numbers in the unvaccinated.
The US Center for Disease Control (CDC) is altering its practices of data logging and testing for "Covid19" in order to make it seem the experimental gene-therapy "vaccines" are effective at preventing the alleged disease.
They made no secret of this, announcing the policy changes on their website in late April/early May, (though naturally without admitting the fairly obvious motivation behind the change).
The trick is in their reporting of what they call "breakthrough infections" – that is people who are fully "vaccinated" against Sars-Cov-2 infection, but get infected anyway.
Essentially, Covid19 has long been shown – to those willing to pay attention – to be an entirely created pandemic narrative built on two key factors:
False-positive tests. The unreliable PCR test can be manipulated into reporting a high number of false-positives by altering the cycle threshold (CT value)
Inflated Case-count. The incredibly broad definition of "Covid case", used all over the world, lists anyone who receives a positive test as a "Covid19 case", even if they never experienced any symptoms .
Without these two policies, there would never have been an appreciable pandemic at all , and now the CDC has enacted two policy changes which means they no longer apply to vaccinated people.
Firstly, they are lowering their CT value when testing samples from suspected "breakthrough infections".
From the CDC's instructions for state health authorities on handling "possible breakthrough infections" (uploaded to their website in late April):
For cases with a known RT-PCR cycle threshold (Ct) value, submit only specimens with Ct value ≤28 to CDC for sequencing. (Sequencing is not feasible with higher Ct values.)
Throughout the pandemic, CT values in excess of 35 have been the norm, with labs around the world going into the 40s.
Essentially labs were running as many cycles as necessary to achieve a positive result, despite experts warning that this was pointless ( even Fauci himself said anything over 35 cycles is meaningless ).
But NOW, and only for fully vaccinated people, the CDC will only accept samples achieved from 28 cycles or fewer. That can only be a deliberate decision in order to decrease the number of "breakthrough infections" being officially recorded.
Secondly, asymptomatic or mild infections will no longer be recorded as "covid cases".
That's right. Even if a sample collected at the low CT value of 28 can be sequenced into the virus alleged to cause Covid19, the CDC will no longer be keeping records of breakthrough infections that don't result in hospitalisation or death .
From their website :
As of May 1, 2021, CDC transitioned from monitoring all reported vaccine breakthrough cases to focus on identifying and investigating only hospitalized or fatal cases due to any cause. This shift will help maximize the quality of the data collected on cases of greatest clinical and public health importance. Previous case counts, which were last updated on April 26, 2021, are available for reference only and will not be updated moving forward.
Just like that, being asymptomatic – or having only minor symptoms – will no longer count as a "Covid case" but only if you've been vaccinated.
The CDC has put new policies in place which effectively created a tiered system of diagnosis. Meaning, from now on, unvaccinated people will find it much easier to be diagnosed with Covid19 than vaccinated people.
Consider
Person A has not been vaccinated. They test positive for Covid using a PCR test at 40 cycles and, despite having no symptoms, they are officially a "covid case".
Person B has been vaccinated. They test positive at 28 cycles, and spend six weeks bedridden with a high fever. Because they never went into a hospital and didn't die they are NOT a Covid case.
Person C , who was also vaccinated, did die. After weeks in hospital with a high fever and respiratory problems. Only their positive PCR test was 29 cycles, so they're not officially a Covid case either.
The CDC is demonstrating the beauty of having a "disease" that can appear or disappear depending on how you measure it.
To be clear: If these new policies had been the global approach to "Covid" since December 2019, there would never have been a pandemic at all.
If you apply them only to the vaccinated, but keep the old rules for the unvaccinated, the only possible result can be that the official records show "Covid" is much more prevalent among the latter than the former.
This is a policy designed to continuously inflate one number, and systematically minimise the other.
What is that if not an obvious and deliberate act of deception? play_arrow
ArkansasAngie 7 hours ago remove link
JakeIsNotFake 14 hours ago remove linkReminds me of money supply numbers. And inflation numbers. And GDP numbers. And unemployment numbers. Oh ... and votes
What is that if not an obvious and deliberate act of deception?
Well, before 3/20, this would have been a FELONY. Each time a lab provided a patient with KNOWINGLY FALSE test results, the lab and the doctor would have been subject to a 16 month term in the state penitentiary. For each instance.
Can you imagine getting a positive, terminal prognosis, committing a well deserved murder, and then not dying?
Oopsie! My bad.
Jun 27, 2020 | off-guardian.org
Though the whole world relies on RT-PCR to "diagnose" Sars-Cov-2 infection, the science is clear: they are not fit for purpose
Moreover, it is worth mentioning that the PCR tests used to identify so-called COVID-19 patients presumably infected by what is called SARS-CoV-2 do not have a valid gold standard to compare them with.
This is a fundamental point. Tests need to be evaluated to determine their preciseness -- strictly speaking their "sensitivity"[ 1 ] and "specificity" -- by comparison with a "gold standard," meaning the most accurate method available.
As an example, for a pregnancy test the gold standard would be the pregnancy itself. But as Australian infectious diseases specialist Sanjaya Senanayake, for example, stated in an ABC TV interview in an answer to the question "How accurate is the [COVID-19] testing?" :
If we had a new test for picking up [the bacterium] golden staph in blood, we've already got blood cultures, that's our gold standard we've been using for decades, and we could match this new test against that. But for COVID-19 we don't have a gold standard test."
Jessica C. Watson from Bristol University confirms this. In her paper "Interpreting a COVID-19 test result" , published recently in The British Medical Journal , she writes that there is a "lack of such a clear-cut 'gold-standard' for COVID-19 testing."
But instead of classifying the tests as unsuitable for SARS-CoV-2 detection and COVID-19 diagnosis, or instead of pointing out that only a virus, proven through isolation and purification, can be a solid gold standard, Watson claims in all seriousness that, "pragmatically" COVID-19 diagnosis itself, remarkably including PCR testing itself, "may be the best available 'gold standard'." But this is not scientifically sound.
Apart from the fact that it is downright absurd to take the PCR test itself as part of the gold standard to evaluate the PCR test, there are no distinctive specific symptoms for COVID-19, as even people such as Thomas Löscher, former head of the Department of Infection and Tropical Medicine at the University of Munich and member of the Federal Association of German Internists, conceded to us[ 2 ].
And if there are no distinctive specific symptoms for COVID-19, COVID-19 diagnosis -- contrary to Watson's statement -- cannot be suitable for serving as a valid gold standard.
In addition, "experts" such as Watson overlook the fact that only virus isolation, i.e. an unequivocal virus proof, can be the gold standard.
That is why I asked Watson how COVID-19 diagnosis "may be the best available gold standard," if there are no distinctive specific symptoms for COVID-19, and also whether the virus itself, that is virus isolation, wouldn't be the best available/possible gold standard. But she hasn't answered these questions yet – despite multiple requests. And she has not yet responded to our rapid response post on her article in which we address exactly the same points, either, though she wrote us on June 2nd : "I will try to post a reply later this week when I have a chance."
NO PROOF FOR THE RNA BEING OF VIRAL ORIGINNow the question is: What is required first for virus isolation/proof? We need to know where the RNA for which the PCR tests are calibrated comes from.
As textbooks (e.g., White/Fenner. Medical Virology, 1986, p. 9) as well as leading virus researchers such as Luc Montagnier or Dominic Dwyer state , particle purification -- i.e. the separation of an object from everything else that is not that object, as for instance Nobel laureate Marie Curie purified 100 mg of radium chloride in 1898 by extracting it from tons of pitchblende -- is an essential pre-requisite for proving the existence of a virus, and thus to prove that the RNA from the particle in question comes from a new virus.
The reason for this is that PCR is extremely sensitive, which means it can detect even the smallest pieces of DNA or RNA -- but it cannot determine where these particles came from . That has to be determined beforehand.
And because the PCR tests are calibrated for gene sequences (in this case RNA sequences because SARS-CoV-2 is believed to be a RNA virus), we have to know that these gene snippets are part of the looked-for virus. And to know that, correct isolation and purification of the presumed virus has to be executed.
Hence, we have asked the science teams of the relevant papers which are referred to in the context of SARS-CoV-2 for proof whether the electron-microscopic shots depicted in their in vitro experiments show purified viruses.
But not a single team could answer that question with "yes" -- and NB., nobody said purification was not a necessary step. We only got answers like "No, we did not obtain an electron micrograph showing the degree of purification" (see below).
We asked several study authors "Do your electron micrographs show the purified virus?", they gave the following responses:
Study 1: Leo L. M. Poon; Malik Peiris. "Emergence of a novel human coronavirus threatening human health" Nature Medicine , March 2020
Replying Author: Malik Peiris
Date: May 12, 2020
Answer: "The image is the virus budding from an infected cell. It is not purified virus."Study 2: Myung-Guk Han et al. "Identification of Coronavirus Isolated from a Patient in Korea with COVID-19", Osong Public Health and Research Perspectives , February 2020
Replying Author: Myung-Guk Han
Date: May 6, 2020
Answer: "We could not estimate the degree of purification because we do not purify and concentrate the virus cultured in cells."Study 3: Wan Beom Park et al. "Virus Isolation from the First Patient with SARS-CoV-2 in Korea", Journal of Korean Medical Science , February 24, 2020
Replying Author: Wan Beom Park
Date: March 19, 2020
Answer: "We did not obtain an electron micrograph showing the degree of purification."Study 4: Na Zhu et al., "A Novel Coronavirus from Patients with Pneumonia in China", 2019, New England Journal of Medicine , February 20, 2020
Replying Author: Wenjie Tan
Date: March 18, 2020
Answer: "[We show] an image of sedimented virus particles, not purified ones."Regarding the mentioned papers it is clear that what is shown in the electron micrographs (EMs) is the end result of the experiment, meaning there is no other result that they could have made EMs from.
That is to say, if the authors of these studies concede that their published EMs do not show purified particles, then they definitely do not possess purified particles claimed to be viral. (In this context, it has to be remarked that some researchers use the term "isolation" in their papers, but the procedures described therein do not represent a proper isolation (purification) process. Consequently, in this context the term "isolation" is misused).
Thus, the authors of four of the principal, early 2020 papers claiming discovery of a new coronavirus concede they had no proof that the origin of the virus genome was viral-like particles or cellular debris, pure or impure, or particles of any kind. In other words, the existence of SARS-CoV-2 RNA is based on faith, not fact.
We have also contacted Dr Charles Calisher, who is a seasoned virologist. In 2001, Science published an "impassioned plea to the younger generation" from several veteran virologists, among them Calisher, saying that:
[modern virus detection methods like] sleek polymerase chain reaction [ ] tell little or nothing about how a virus multiplies, which animals carry it, [or] how it makes people sick. [It is] like trying to say whether somebody has bad breath by looking at his fingerprint."[ 3 ]
And that's why we asked Dr Calisher whether he knows one single paper in which SARS-CoV-2 has been isolated and finally really purified. His answer:
I know of no such a publication. I have kept an eye out for one."[ 4 ]
This actually means that one cannot conclude that the RNA gene sequences, which the scientists took from the tissue samples prepared in the mentioned in vitro trials and for which the PCR tests are finally being "calibrated," belong to a specific virus -- in this case SARS-CoV-2.
In addition, there is no scientific proof that those RNA sequences are the causative agent of what is called COVID-19.
In order to establish a causal connection, one way or the other, i.e. beyond virus isolation and purification, it would have been absolutely necessary to carry out an experiment that satisfies the four Koch's postulates. But there is no such experiment, as Amory Devereux and Rosemary Frei recently revealed for OffGuardian .
The necessity to fulfill these postulates regarding SARS-CoV-2 is demonstrated not least by the fact that attempts have been made to fulfill them. But even researchers claiming they have done it, in reality, did not succeed.
One example is a study published in Nature on May 7 . This trial, besides other procedures which render the study invalid, did not meet any of the postulates.
For instance, the alleged "infected" laboratory mice did not show any relevant clinical symptoms clearly attributable to pneumonia, which according to the third postulate should actually occur if a dangerous and potentially deadly virus was really at work there. And the slight bristles and weight loss, which were observed temporarily in the animals are negligible, not only because they could have been caused by the procedure itself, but also because the weight went back to normal again.
Also, no animal died except those they killed to perform the autopsies . And let's not forget: These experiments should have been done before developing a test, which is not the case.
Revealingly, none of the leading German representatives of the official theory about SARS-Cov-2/COVID-19 -- the Robert Koch-Institute (RKI), Alexander S. Kekulé (University of Halle), Hartmut Hengel and Ralf Bartenschlager (German Society for Virology), the aforementioned Thomas Löscher, Ulrich Dirnagl (Charité Berlin) or Georg Bornkamm (virologist and professor emeritus at the Helmholtz-Zentrum Munich) -- could answer the following question I have sent them:
If the particles that are claimed to be to be SARS-CoV-2 have not been purified, how do you want to be sure that the RNA gene sequences of these particles belong to a specific new virus?
Particularly, if there are studies showing that substances such as antibiotics that are added to the test tubes in the in vitro experiments carried out for virus detection can "stress" the cell culture in a way that new gene sequences are being formed that were not previously detectable -- an aspect that Nobel laureate Barbara McClintock already drew attention to in her Nobel Lecture back in 1983 .
It should not go unmentioned that we finally got the Charité – the employer of Christian Drosten, Germany's most influential virologist in respect of COVID-19, advisor to the German government and co-developer of the PCR test which was the first to be "accepted" ( not validated! ) by the WHO worldwide – to answer questions on the topic.
But we didn't get answers until June 18, 2020, after months of non-response. In the end, we achieved it only with the help of Berlin lawyer Viviane Fischer.
Regarding our question "Has the Charité convinced itself that appropriate particle purification was carried out?," the Charité concedes that they didn't use purified particles.
And although they claim "virologists at the Charité are sure that they are testing for the virus," in their paper ( Corman et al. ) they state:
RNA was extracted from clinical samples with the MagNA Pure 96 system (Roche, Penzberg, Germany) and from cell culture supernatants with the viral RNA mini kit (QIAGEN, Hilden, Germany),"
Which means they just assumed the RNA was viral .
Incidentally, the Corman et al. paper, published on January 23, 2020 didn't even go through a proper peer review process , nor were the procedures outlined therein accompanied by controls -- although it is only through these two things that scientific work becomes really solid.
IRRATIONAL TEST RESULTSIt is also certain that we cannot know the false positive rate of the PCR tests without widespread testing of people who certainly do not have the virus, proven by a method which is independent of the test (having a solid gold standard).
Therefore, it is hardly surprising that there are several papers illustrating irrational test results.
For example, already in February the health authority in China's Guangdong province reported that people have fully recovered from illness blamed on COVID-19, started to test "negative," and then tested "positive" again .
A month later, a paper published in the Journal of Medical Virology showed that 29 out of 610 patients at a hospital in Wuhan had 3 to 6 test results that flipped between "negative", "positive" and "dubious" .
A third example is a study from Singapore in which tests were carried out almost daily on 18 patients and the majority went from "positive" to "negative" back to "positive" at least once, and up to five times in one patient .
Even Wang Chen, president of the Chinese Academy of Medical Sciences, conceded in February that the PCR tests are "only 30 to 50 per cent accurate" ; while Sin Hang Lee from the Milford Molecular Diagnostics Laboratory sent a l etter to the WHO's coronavirus response team and to Anthony S. Fauci on March 22, 2020, saying that:
It has been widely reported in the social media that the RT-qPCR [Reverse Transcriptase quantitative PCR] test kits used to detect SARSCoV-2 RNA in human specimens are generating many false positive results and are not sensitive enough to detect some real positive cases."
In other words, even if we theoretically assume that these PCR tests can really detect a viral infection, the tests would be practically worthless, and would only cause an unfounded scare among the "positive" people tested.
This becomes also evident considering the positive predictive value (PPV).
The PPV indicates the probability that a person with a positive test result is truly "positive" (ie. has the supposed virus), and it depends on two factors: the prevalence of the virus in the general population and the specificity of the test, that is the percentage of people without disease in whom the test is correctly "negative" (a test with a specificity of 95% incorrectly gives a positive result in 5 out of 100 non-infected people).
With the same specificity, the higher the prevalence, the higher the PPV.
In this context, on June 12 2020, the journal Deutsches Ärzteblatt published an article in which the PPV has been calculated with three different prevalence scenarios .
The results must, of course, be viewed very critically, first because it is not possible to calculate the specificity without a solid gold standard, as outlined, and second because the calculations in the article are based on the specificity determined in the study by Jessica Watson, which is potentially worthless, as also mentioned.
But if you abstract from it, assuming that the underlying specificity of 95% is correct and that we know the prevalence, even the mainstream medical journal Deutsches Ärzteblatt reports that the so-called SARS-CoV-2 RT-PCR tests may have "a shockingly low" PPV.
In one of the three scenarios, figuring with an assumed prevalence of 3%, the PPV was only 30 percent, which means that 70 percent of the people tested "positive" are not "positive" at all . Yet "they are prescribed quarantine," as even the Ärzteblatt notes critically.
In a second scenario of the journal's article, a prevalence of rate of 20 percent is assumed. In this case they generate a PPV of 78 percent, meaning that 22 percent of the "positive" tests are false "positives."
That would mean: If we take the around 9 million people who are currently considered "positive" worldwide -- supposing that the true "positives" really have a viral infection -- we would get almost 2 million false "positives."
All this fits with the fact that the CDC and the FDA, for instance, concede in their files that the so-called "SARS-CoV-2 RT-PCR tests" are not suitable for SARS-CoV-2 diagnosis.
In the "CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel" file from March 30, 2020, for example, it says:
Detection of viral RNA may not indicate the presence of infectious virus or that 2019-nCoV is the causative agent for clinical symptoms"
And:
This test cannot rule out diseases caused by other bacterial or viral pathogens."
And the FDA admits that :
positive results [ ] do not rule out bacterial infection or co-infection with other viruses. The agent detected may not be the definite cause of disease."
Remarkably, in the instruction manuals of PCR tests we can also read that they are not intended as a diagnostic test, as for instance in those by Altona Diagnostics and Creative Diagnostics[ 5 ].
To quote another one, in the product announcement of the LightMix Modular Assays produced by TIB Molbiol -- which were developed using the Corman et al. protocol -- and distributed by Roche we can read:
These assays are not intended for use as an aid in the diagnosis of coronavirus infection"
And:
For research use only. Not for use in diagnostic procedures."
WHERE IS THE EVIDENCE THAT THE TESTS CAN MEASURE THE "VIRAL LOAD"?There is also reason to conclude that the PCR test from Roche and others cannot even detect the targeted genes .
Moreover, in the product descriptions of the RT-qPCR tests for SARS-COV-2 it says they are "qualitative" tests , contrary to the fact that the "q" in "qPCR" stands for "quantitative." And if these tests are not "quantitative" tests, they don't show how many viral particles are in the body .
That is crucial because, in order to even begin talking about actual illness in the real world not only in a laboratory, the patient would need to have millions and millions of viral particles actively replicating in their body.
That is to say, the CDC, the WHO, the FDA or the RKI may assert that the tests can measure the so-called "viral load," i.e. how many viral particles are in the body. "But this has never been proven. That is an enormous scandal," as the journalist Jon Rappoport points out .
This is not only because the term "viral load" is deception. If you put the question "what is viral load?" at a dinner party, people take it to mean viruses circulating in the bloodstream. They're surprised to learn it's actually RNA molecules.
Also, to prove beyond any doubt that the PCR can measure how much a person is "burdened" with a disease-causing virus, the following experiment would have had to be carried out (which has not yet happened):
You take, let's say, a few hundred or even thousand people and remove tissue samples from them. Make sure the people who take the samples do not perform the test.The testers will never know who the patients are and what condition they're in. The testers run their PCR on the tissue samples. In each case, they say which virus they found and how much of it they found. Then, for example, in patients 29, 86, 199, 272, and 293 they found a great deal of what they claim is a virus. Now we un-blind those patients. They should all be sick, because they have so much virus replicating in their bodies. But are they really sick -- or are they fit as a fiddle?
With the help of the aforementioned lawyer Viviane Fischer, I finally got the Charité to also answer the question of whether the test developed by Corman et al. -- the so-called "Drosten PCR test" -- is a quantitative test.
But the Charité was not willing to answer this question "yes". Instead, the Charité wrote:
If real-time RT-PCR is involved, to the knowledge of the Charité in most cases these are [ ] limited to qualitative detection."
Furthermore, the "Drosten PCR test" uses the unspecific E-gene assay as preliminary assay , while the Institut Pasteur uses the same assay as confirmatory assay .
According to Corman et al ., the E-gene assay is likely to detect all Asian viruses , while the other assays in both tests are supposed to be more specific for sequences labelled "SARS-CoV-2".
Besides the questionable purpose of having either a preliminary or a confirmatory test that is likely to detect all Asian viruses, at the beginning of April the WHO changed the algorithm, recommending that from then on a test can be regarded as "positive" even if just the E-gene assay (which is likely to detect all Asian viruses! ) gives a "positive" result .
This means that a confirmed unspecific test result is officially sold as specific .
That change of algorithm increased the "case" numbers. Tests using the E-gene assay are produced for example by Roche , TIB Molbiol and R-Biopharm .
HIGH CQ VALUES MAKE THE TEST RESULTS EVEN MORE MEANINGLESSAnother essential problem is that many PCR tests have a "cycle quantification" (Cq) value of over 35, and some, including the "Drosten PCR test", even have a Cq of 45.
The Cq value specifies how many cycles of DNA replication are required to detect a real signal from biological samples.
"Cq values higher than 40 are suspect because of the implied low efficiency and generally should not be reported," as it says in the MIQE guidelines .
MIQE stands for "Minimum Information for Publication of Quantitative Real-Time PCR Experiments", a set of guidelines that describe the minimum information necessary for evaluating publications on Real-Time PCR, also called quantitative PCR, or qPCR.
The inventor himself, Kary Mullis, agreed, when he stated :
If you have to go more than 40 cycles to amplify a single-copy gene, there is something seriously wrong with your PCR."
The MIQE guidelines have been developed under the aegis of Stephen A. Bustin , Professor of Molecular Medicine, a world-renowned expert on quantitative PCR and author of the book A-Z of Quantitative PCR which has been called "the bible of qPCR."
In a recent podcast interview Bustin points out that "the use of such arbitrary Cq cut-offs is not ideal, because they may be either too low (eliminating valid results) or too high (increasing false "positive" results)."
https://www.podbean.com/media/player/znrvk-d932a7?from=usersite&vjs=1&skin=1&fonts=Helvetica&auto=0&download=1
And, according to him, a Cq in the 20s to 30s should be aimed at and there is concern regarding the reliability of the results for any Cq over 35.
If the Cq value gets too high, it becomes difficult to distinguish real signal from background, for example due to reactions of primers and fluorescent probes, and hence there is a higher probability of false positives.
Moreover, among other factors that can alter the result, before starting with the actual PCR, in case you are looking for presumed RNA viruses such as SARS-CoV-2, the RNA must be converted to complementary DNA (cDNA) with the enzyme Reverse Transcriptase -- hence the "RT" at the beginning of "PCR" or "qPCR."
But this transformation process is "widely recognized as inefficient and variable," as Jessica Schwaber from the Centre for Commercialization of Regenerative Medicine in Toronto and two research colleagues pointed out in a 2019 paper .
Stephen A. Bustin acknowledges problems with PCR in a comparable way.
For example, he pointed to the problem that in the course of the conversion process (RNA to cDNA) the amount of DNA obtained with the same RNA base material can vary widely, even by a factor of 10 (see above interview).
Considering that the DNA sequences get doubled at every cycle, even a slight variation becomes magnified and can thus alter the result, annihilating the test's reliable informative value.
So how can it be that those who claim the PCR tests are highly meaningful for so-called COVID-19 diagnosis blind out the fundamental inadequacies of these tests -- even if they are confronted with questions regarding their validity?
Certainly, the apologists of the novel coronavirus hypothesis should have dealt with these questions before throwing the tests on the market and putting basically the whole world under lockdown, not least because these are questions that come to mind immediately for anyone with even a spark of scientific understanding.
Thus, the thought inevitably emerges that financial and political interests play a decisive role for this ignorance about scientific obligations. NB, the WHO, for example has financial ties with drug companies, as the British Medical Journal showed in 2010 .
And experts criticize "that the notorious corruption and conflicts of interest at WHO have continued, even grown" since then. The CDC as well, to take another big player, is obviously no better off .
Finally, the reasons and possible motives remain speculative, and many involved surely act in good faith; but the science is clear: The numbers generated by these RT-PCR tests do not in the least justify frightening people who have been tested "positive" and imposing lockdown measures that plunge countless people into poverty and despair or even drive them to suicide.
And a "positive" result may have serious consequences for the patients as well, because then all non-viral factors are excluded from the diagnosis and the patients are treated with highly toxic drugs and invasive intubations. Especially for elderly people and patients with pre-existing conditions such a treatment can be fatal, as we have outlined in the article "Fatal Therapie."
Without doubt eventual excess mortality rates are caused by the therapy and by the lockdown measures, while the "COVID-19" death statistics comprise also patients who died of a variety of diseases, redefined as COVID-19 only because of a "positive" test result whose value could not be more doubtful.
Sollipsist , says: March 30, 2021 at 4:04 am GMT • 1.9 days agoMar 31, 2021 | www.unz.com
,
The pawpaw and the goat are both listed in stable condition for now.
The sheep, of course, tested negative and has since received 8 marriage proposals from relieved Tanazanian suitors.
Mar 26, 2021 | www.zerohedge.com
Finally, COVID vaccinations are re-accelerating in US and EU...
Source: Bloomberg
And while cases are up modestly (are PCR tests picking up spike proteins from the mRNA vaccines?), death rates continue to tumble...
Mar 14, 2021 | www.brighteon.com
Steven Keith • a day ago ,As reported by FDA/CDC:
FDA - U.S. Food and Drug Administration
CDC - Centers for Disease Control and Prevention
"SINCE NO QUANTIFIED VIRUS ISOLATES OF THE 2019-nCoV were available for CDC use at the time the test was developed and this study conducted, assays designed for detection of the 2019-nCoV RNA were tested with characterized stocks of in vitro transcribed full length RNA..."
Scroll to page 42 link:
https://www.fda.gov/media/1...Kary Mullis: PCR Test Inventor Calls Dr Fauci a Fraud (polymerase chain reaction, or reverse transcription polymerase chain reaction)
https://odysee.com/@Quantum...CDC "Gold Standard" (PCR) Polymerase Chain Reaction test. False Positive Problem:
https://www.nejm.org/doi/fu...Disturbing Vaccine Facts - (The WHO etc. "Experts & Leaders" of infectious disease proving from their own mouths Vaccines are not safe)
https://www.bitchute.com/vi...
Mar 01, 2021 | www.moonofalabama.org
lulu , Nov 27 2020 18:04 utc | 121
A European court declares the RT-PCR test worthless.
https://www.rt.com/op-ed/507937-covid-pcr-test-fail/Posted by: Palinurus | Nov 27 2020 10:21 utc | 102
---------------------------------------------------The judges in Portugal drew their conclusion basing on the following technicalities:
1.
The judges also said that only a doctor can "diagnose" someone with a disease, and were critical of the fact that they were apparently never assessed by one .
<--- It says nothing about PCR test "worthless".
2.In the eyes of this court, then, a positive test does not correspond to a Covid case. The two most important reasons for this, said the judges, are that, "the test's reliability depends on the number of cycles used '' and that "the test's reliability depends on the viral load present .'
<--- The judges simply argued on technicality: the higher the cycle threshold (Ct) of a PCR test is, the higher the chance of the test turning out positively.According to the research paper linked in your RT article Correlation Between 3790 Quantitative Polymerase Chain Reaction–Positives Samples and Positive Cell Cultures, Including 1941 Severe Acute Respiratory Syndrome Coronavirus 2 Isolates ,
Several recent publications, based on more than 100 studies, have attempted to propose a cutoff Ct value and duration of eviction , with a consensus at approximately Ct >30 and at least 10 days, respectively. However, in an article published in Clinical Infectious Diseases, Bullard et al reported that patients could not be contagious with Ct >25 as the virus is not detected in culture above this value.The real argument is probably whether decision-makers (doctors, public health authority) should take the lower Ct for PCR tests or not, which affects their consequential decisions, for example, quarantine time of 10-day vs 14-day, the effectiveness control of Covid 19 contagion.
vk , Nov 27 2020 18:26 utc | 123
vk , Nov 27 2020 19:29 utc | 129@ Posted by: Palinurus | Nov 27 2020 10:21 utc | 102
lulu @ 121 is correct: diagnosis ≠ track and tracing.
PCR is just for track and tracing, not for diagnosis. The diagnosis protocol is much longer and burdensome, and includes an MRI of the lungs if I'm not mistaken (and can only be made by a doctor). The Portuguese judges are, therefore, also correct.
oldhippie , Nov 27 2020 19:46 utc | 130@ Posted by: oldhippie | Nov 27 2020 19:23 utc | 127
There are two problems with your theory:
1) Fauci is not a reliable source;
2) China uses a 40-cycle PCR test, used it on Wuhan's entire population (almost 10 million) after a scare and found no positive results.
We already talked about the Portuguese case. The judges were probably amid a labor dispute and, in a pro-business decision, reiterated that PCR is not diagnosis.
vk @ 129
Administer a test 10 million times and every result the same? And you believe this? Amplify a signal by a trillion and there is never a problem with noise? Oh, it is in Chinese wonderland, makes perfect sense.
Always apples and oranges with you. Same as it it would be talking to an illiterate. Or a wall.
Feb 05, 2021 | www.zerohedge.com
As Chris Martenson (PhD in pathology from Duke University) outlines in the 2020 Year in Review with Dave Collum (PhD Columbia, Chemistry, teaches at Cornell): a medical "case" is one in which a patient is presenting symptoms and requires medical attention. That's a case. PCR tests were never meant to discern whether somebody is an "infected case" or not, and as Collum elaborated in that same interview, "with a Cycle Threshold over 35, you can get a positive PCR test out of a dog's ass".
- Daily new cases of COVID-21 hospitalizations and COVID-19 and COVID-21 related deaths will exceed medical care facilities capacity. Expected Q1 – Q2 2021.
According to the media, this is true. According to reality, it isn't. In CNN-style "fact checking" parlance, it would thus score as "partially true".
"Covid Related Deaths" is a well worn catch-all. What is known to anybody keeping track: the vast majority of COVID fatalities are with COVID, not from it. We all know this, for some reason it doesn't seem to matter. The overall survival rate for this thing is somewhere around 97% or higher. Most people don't know anybody in their immediate circle of friends and family that have actually died from it.
It can be terrible virus to catch and become sick with, and it's tragic to die from. But the majority of people either exhibit flu like symptoms and shrug it off or remain completely asymptomatic. Overall it causes fewer fatalities to society than either alcohol (3 million deaths per year, globally) or driving (1.5 million) or for that matter air pollution at 4.2 million.
- Enhanced lock down restrictions (referred to as Third Lock Down) will be implemented. Full travel restrictions will be imposed (including inter-province and inter-city). Expected Q2 2021.
Jan 26, 2021 | off-guardian.org
Moneycircus , Jan 23, 2021 5:40 PM
UK Column News – 22nd January 2021
PART ONE
WHO BELATEDLY ADMITS LIMITATIONS OF PCR TEST
INSTITUTIONAL FRAUD ON GLOBAL SCALE REVEALED
Countries bankrupted, children's future compromised. Nuremberg trials await.
WHO must have known how PCR test worked in Jan 2020. Now they admit, a year later, that tests are misleading. One day after Biden installed as the illegitimate president of the U.S.SUGGESTS MANY TESTS ARE PRODUCING FALSE POSITIVES
WHO REVERSAL ON PCR TESTS
The less disease out there, the greater risk of false positives. Careful interpretation of positive results is needed -- exactly what PCR test inventor Kary Mullis said
https://www.who.int/news/item/20-01-2021-who-information-notice-for-ivd-users-2020-05KEEP TESTING AND YOU WILL FIND ANYTHING – EXACTLY WHAT KARY MULLIS SAID
TRANSLATION: SET THE GAIN TOO HIGH AND YOU GET FALSE DETECTIONS
The cycle threshold (Ct) needed to detect virus is inversely proportional to the patient's viral load.
Kary Mullis won a Nobel Prize for inventing the test so should know its limitations. Sadly he died, Aug 2019. Mullis said his PCR test should not be used to diagnose illness. PCR test can detect DNA fragments from past diseases or from your body. Claims of "Covid" detection actually detects these irrelevant fragments. PCR findings are supposed to be backed up by clinical diagnosis of illness.GBP 500 BRIBE FOR A JAB UNDER CONSIDERATION
UK unHEALTH SECRETARY MATT HANDCOCK SEES NO LIMIT TO GOV SPENDING
Environment Sec George Eustace says it's on the table
Mike Robinson: this is probably a trial balloon to see who the narrative fares. 500 a person will be 450 million a week. UK borrowing hit a record in Dec.
Patrick Henningsen: the question is how much will it cost the gov to find new cases.PM WON'T COMMIT TO ENDING LOCKDOWN
ANYWAY HE TALKS POSH SO THAT SHOULD PERSUADE YOU.
BoJo talks plum bull, chews words, talks guff, won't commit.STILL NO INFORMATION ON WHETHER DEATHS ARE RISING OR WHY
NHS REMAINS EFFECTIVELY CLOSED TO ALL ILLNESSES
Are people dying from failure to treat elderly with flu or pneumonia?CENSORSHIP RULES AS SOCIAL MEDIA UPHOLD GOV NARRATIVE
PRESS IS RAKING IN GOV ADVERTISING
Emily Hill, in Spiked: It is a journalist's duty to question lockdown
https://www.spiked-online.com/2021/01/20/it-is-a-journalists-duty-to-question-lockdown/WMHRA'S CEO JUNE RAINE: NOTHING UNUSUAL IN ADVERSE REACTIONS
EU CRITICISED HASTY APPROVAL
Reports are coming in thick and fast to the yellow card adverse reaction scheme.
Raine is a career civil servant. Been on WHO safety committees. "Risk communication and patient involvement" is her speciality.
Pfizer jab was "judged safe" and "far outweigh any risk", Raine said in Dec 2020, although there had been no risk assessment. She also claimed the UK regulator did not cut any corners. Yet phase three tests were not completed and won't be until Jan 2023. The EU criticised "hasty" UK approval.
Mike Robinson: the public is the phase three trial. The public at large is the test group.UNIONS NOW OBLIGING MEMBERS TO COMPLY WITH VACCINATIONS.
HISTORIC SUPPORT FOR CIVIL LIBERTIES ABANDONED.
Patrick Henningsen: what happened to the left. They used to question the government and favour liberty. Now unions are channeling gov policy and requiring members to get vaccinations to work.
Mike Robinson: gov says vaccine is not mandatory but employers and unions are making it so.OVER-50s SAGA GROUP FALLS IN LINE WITH VAX PASSPORTS
MEMBERS REBEL AGAINST UNLAWFUL DEMANDS AND VIRTUE SIGNALLING
Saga says members must be "vaccinated" against Covid 14 days before travel. Members say demand violates Nuremberg code, accuse company of virtue signalling.
Mike Robinson: dozens of companies seek to profit from the security and surveillance space and health profits.
Patrick Henningsen: this is a gravy train driven by hoped-for profits.JUST SAY NO -- CONVENTION ON BIOETHICS AND HUMAN RIGHTS
UNESCO ARTICLE 6 GIVES RIGHT TO REFUSE VACCINATION WITH NO RETRIBUTION"The consent should, where appropriate, be expressed and may be withdrawn by the person concerned at any time and for any reason without disadvantage or prejudice."
Mike Robinson: the principle is there but it is not binding in any way
NORTHERN IRELAND LOCKDOWN EXTENDED TO MAR 5
HONG KONG LAUNCHES FIRST LOCKDOWN. WEST MAY COPY
Patrick Henningsen: Where China goes, the west follows. Targeted lockdowns, focused on cities, boroughs, housing estates. Only people with negative tests will be allowed off the leashU.S. PRESIDENTIAL INSTALLATION FAKENESS
OFFICIAL PORTRAITS OF BIDEN ARE VERY ORANGE
Trumpian imagery, strange presence of PermaOrange in U.S. presidential photos.
Patrick Henningsen: Lack of attendees blamed on social distancing. loads of sports events see none of this distancing, the NFL football for instance.GUSHING MEDIA FINALLY FREE
TRUMP DERANGEMENT SYNDROME ABATES TEMPORARILY
CNN Jeffrey Toobin (fumbulator): Lights laid down from the Lincoln statue to the obelisk were "like Joe Biden's arms embracing America". Toobin resigned in October after playing with himself on a Zoom call. CNN was happy to hire him.CNN Jeff Zeleny: Their majesties Obama, Bush and Clint, recorded a video reflecting "the majesty of the passage of power, importance of upholding democracy".
Mike Robinson: but Bill Clinson fell asleep!!!CNN overcome with Biden on stage with Obama "The comforting sight of the Clintons and the Bushes and the Obamas, the Avengers, the Marvel superheroes back together, with their friend Joe Biden all of them sharing the view of a lot of Americans that we did narrowly avert catastrophe all there to butress their buddy Joe Biden."
Patrick Henningsen: see the infantilization of politics. It has become a spectator sport and politicians have become Marvel superheroes.
EXECUTIVE ORDER: MASK WEARING AND DISTANCING ON FEDERAL PROPERTY
UNLESS YOU ARE DOT GOV
Trump issued the lowest number of executive orders in recent times. Biden issued 17 on day one and plans dozens in the first weeks of his installation.BBC: KAMALA HARRIS A PRESIDENT IN WAITING?
ALREADY ASSUMED HAZY KAMALA WILL TAKE OVER
Patrick Henningsen: Joe Biden is not in his prime. He lacks the energy to lead the U.S. -- he could barely campaign.FOREIGN POLICY OUTLOOK
U.S. OFFERS TO WORK WITH UK ON CHINA
Politico: UK's pitch to Biden: We'll work with you on China
https://www.politico.eu/article/uk-pitch-joe-biden-china-us-trade/MARK SEDWILL RUNNING UK FOREIGN POLICY
NAME APPEARS AS HEAD OF VARIOUS QUASI GOV BODIES
China is a major set piece. Britain makes a play to outdo the EU on its aproach to China.
COP 26 and climate change take prominence. Biden due to visit Britain for G7 in Cornwall in Jun 2021. D10 floated as democracy election: G7 + India, South Korea and Australia
Mike Robinson: the war narrative is broader than Covid -- aim in this case being to peel India away from BRICSMACRON CALLS ON BIDEN FOR GREATER U.S. INVOLVEMENT
OTAN AKBAR!
Obama doctrine, Clinton doctrine is back – arming "moderate rebels", targeting Syria, Sahel region for western interests. Biden admin will need to make greater commitments on Syria and Iraq, sending troops back, undoing Trump's withdrawal.Moneycircus , Jan 23, 2021 5:52 PM Reply to Moneycircus
UK Column News – 22nd January 2021
PART TWOMAGICAL BAGHDAD BOMBING DAY AFTER BIDEN INSTALLATION
PROMPTS DEMAND TO ADD THOUSANDS OF U.S. TROOPS TO COMBAT REGIONAL TERROR
Bomb went off in market not far from U.S. embassy. Islamic State claimed responsibility for two bombs that killed over 30 and injured 100 in central Baghdad.
Patrick Henningsen: we've been told for months that terrorism has been declining in Iraq. Suddenly with Biden comes a new narrative and bombs. If a third party wanted to influence his policy this would be the way to do it.ISIS 'WE BOMBED RANDOM MARKET -- PLEASE OCCUPY IRAQ AGAIN.'
FOREIGN POLICY IS ABOUT BOMBS, INCLUSION AND GENDER
Averil Haines put forward as DNI. Haines is a protégé of Clapper and Brennan.
Women and minorities are filling all these posts. The appearance of diversity: watch policy not change.RACHEL LEVINE, ASST HEALTH SECRETARY
REMOVED OWN MOTHER FROM CARE HOMES BEFORE ORDERING TRANSFER OF SICK ELDERLY
The scandal is the unacceptable action of a dubious individual.
https://www.pennlive.com/news/2020/05/health-secretary-rachel-levines-removal-of-mom-from-care-home-amid-epidemic-draws-scrutiny.htmlLIBERTY GROUPS RESIST FURTHER CLAMPDOWN ON "TERROR"
LEADERSHIP CONFERENCE ON CIVIL AND HUMAN RIGHTS STATEMENT
https://www.naacpldf.org/wp-content/uploads/No_Domestic_Terrorism_Charge_1_19_2021-1.pdf
Patrick Henningsen: Obama administration saw a mass shooting events every second week – pipe bombs and country in permanent fear. At least half the terror events were driven by FBI informants. Dubious events like San Bernardino were used to justify foreign policy adventures in Syria.
Me: In contrast, apart from Las Vegas just after he took office, Trump admin saw relatively few mass shootings.ASSANGE PARDON REPORTEDLY BLOCKED BY MITCH MCCONNELL
TUCKER CARLSON ASSERTS THAT COMPROMISED RINO THREATENED TRUMP
McConnell "sent word over to the White House: if you pardon Julian Assange, we are much more likely to convice you in an impeachment trial."
Patrick Henningsen: such horse trading would not be unusual. Trump missed a chance to go down in history as a champion of free speech and an honest press.
Donald Trump shattered a lot of Republican records. That's not going to be reversed by hunting down Trump and his supporters.CHATHAM HOUSE MASTERCLASS IN MANIPULATING PUBLIC PERCEPTIONS
JAN 2019 INFLUENZA PREPAREDNESS CONFERENCE
Communication and public engagement – MARC VAN RANST – 9: Importance of using the media to push messaging:https://player.vimeo.com/video/320913130
Sitting in the front row was the UK's Jonathn Van Tam, Deputy Chief Medical Officer for England
Marc van Ranst's Masterclass on Manipulating Public Fear for CFR-Chatham Ho.:
"Day one is so important. You start your comms with the press and people. One voice, one message . In Belgium they appointed a non politician [van Ranst himself] to do that. You are then not attacked politically. That was a big advantage. In Brussels you can play the complete naive guy.
"You have to be omnipresent so you attract media attention. You have to make a contract with them that if they call you, you will pick up the phone. If you do that you can profit from these early days to get complete carpet coverage and they are not going to search for alternative voices. And if you do that it makes things easier.
"Then you say we have a certain number of H1N1 deaths, that are unavoidable. I used a quote from Sir Donaldson that at the peak of the epidemic, 40 people would die per day in UK, and I calculated that for Belgium to show there would be 7 deaths a day. That is true in every year (laughter) but talking about fatalities gets attention because people don't usually think about anyone dying from influenza.
"A couple of days later you had the first death of H1N1 in the country and the scene was set and it was already talked about."Mike Robinson: The point he made about deaths is important. You take a number that is normal, it happens every year but it is not usually reported. You start reporting it and people think there is something special about that number. Then you add on the effects of lockdown and you say this is really serious, even though the excess mortality is little different to what's happened in history."
Simples!
UK Column News – 22nd January 2021
https://www.youtube.com/embed/edln7eWn4ck?version=3&rel=1&showsearch=0&showinfo=1&iv_load_policy=1&fs=1&hl=en-US&autohide=2&wmode=transparent
Moneycircus , Jan 23, 2021 6:21 PM Reply to Moneycircus
The Chatham House video can be watched here. Download this handy masterclass on manipulating public fear before it's deleted. MP4 downloader
Moneycircus , Jan 23, 2021 6:16 PM Reply to Moneycircus
Clarification: It was MSNBC national affairs analyst John Heilemann who said seeing the past presidents standing next to Biden was "like the Avengers, sort of the Marvel superheroes, back up there together. "
Jan 24, 2021 | turcopolier.typepad.com
Barbara Ann , 23 January 2021 at 08:08 PM
Patrick
From the ZH article; "None of this was for your health. It was to get rid of Orange Man Bad".
100%. The WHO's revised guidance effectively says the majority of infection data from PCR testing is meaningless. ZH notes Florida as a possible exception. The original guidance issued on 2020/12/14 seems to have been scrubbed from the WHO's website but was archived here: ( https://web.archive.org/web/20210102051357/https://www.who.int/news/item/14-12-2020-who-information-notice-for-ivd-users). ">https://www.who.int/news/item/14-12-2020-who-information-notice-for-ivd-users).">https://web.archive.org/web/20210102051357/https://www.who.int/news/item/14-12-2020-who-information-notice-for-ivd-users). The revised guidance calls for a retest upon a weak positive* result and publication of the Ct value along with the result.
*Why no retest after a weak negative, am I missing something re the risk of false negative results? Otherwise weeding out false positives only looks a lot like a policy to drive down reported infection rates.
The next stage of course is for the CDC to update their guidance (not updated since October) and revise the stats - hey presto pandemic over, all under the Biden administration.
This is the most audacious, yet transparent, PSYOP of all time. I just can't believe someone, somewhere doesn't have hard intel. on whoever is running it.
Jan 24, 2021 | www.globalresearch.ca
Introduction: using a technique to lock down society
All current propaganda on the COVID-19 pandemic is based on an assumption that is considered obvious, true and no longer questioned:
Positive RT-PCR test means being sick with COVID. This assumption is misleading .
Very few people, including doctors, understand how a PCR test works.
RT-PCR means R eal T ime- P olymerase C hain R eaction.
In French, it means: Réaction de Polymérisation en Chaîne en Temps Réel.
In medicine, we use this tool mainly to diagnose a viral infection.
Starting from a clinical situation with the presence or absence of particular symptoms in a patient, we consider different diagnoses based on tests.
In the case of certain infections, particularly viral infections, we use the RT-PCR technique to confirm a diagnostic hypothesis suggested by a clinical picture.
We do not routinely perform RT-PCR on any patient who is overheated, coughing or has an inflammatory syndrome!
It is a laboratory, molecular biology technique of gene amplification because it looks for gene traces (DNA or RNA) by amplifying them.
In addition to medicine, other fields of application are genetics, research, industry and forensics.
The technique is carried out in a specialized laboratory , it cannot be done in any laboratory, even a hospital. This entails a certain cost, and a delay sometimes of several days between the sample and the result.
Today, since the emergence of the new disease called COVID-19 ( CO rona VI rus D isease-20 19 ), the RT-PCR diagnostic technique is used to define positive cases, confirmed as SARS-CoV-2 (coronavirus responsible for the new acute respiratory distress syndrome called COVID-19).
These positive cases are assimilated to COVID-19 cases, some of whom are hospitalized or even admitted to intensive care units.
Official postulate of our managers: positive RT-PCR cases = COVID-19 patients. [1]
This is the starting postulate, the premise of all official propaganda, which justifies all restrictive government measures: isolation, confinement, quarantine, mandatory masks, color codes by country and travel bans, tracking, social distances in companies, stores and even, even more importantly, in schools [2].
This misuse of RT-PCR technique is used as a relentless and intentional strategy by some governments , supported by scientific safety councils and by the dominant media, to justify excessive measures such as the violation of a large number of constitutional rights, the destruction of the economy with the bankruptcy of entire active sectors of society, the degradation of living conditions for a large number of ordinary citizens, under the pretext of a pandemic based on a number of positive RT-PCR tests, and not on a real number of patients .
Technical aspects: to better understand and not be manipulated
The PCR technique was developed by chemist Kary B. Mullis in 1986. Kary Mullis was awarded the Nobel Prize in Chemistry in 1993.
Although this is disputed [3], Kary Mullis himself is said to have criticized the interest of PCR as a diagnostic tool for an infection, especially a viral one.
He stated that if PCR was a good tool for research, it was a very bad tool in medicine, in the clinic [4].
Mullis was referring to the AIDS virus (HIV retrovirus or HIV) [5], before the COVID-19 pandemic, but this opinion on the limitation of the technique in viral infections [6], by its creator, cannot be dismissed out of hand; it must be taken into account!
PCR was perfected in 1992.
As the analysis can be performed in real time, continuously, it becomes RT (Real-Time) – PCR , even more efficient.
It can be done from any molecule, including those of the living, the nucleic acids that make up the genes:
- DNA (deoxyribonucleic acid)
- RNA (Ribonucleic Acid)
Viruses are not considered as "living" beings, they are packets of information (DNA or RNA) forming a genome.
It is by an amplification technique (multiplication) that the molecule sought is highlighted and this point is very important.
RT-PCR is an amplification technique [7].
If there is DNA or RNA of the desired element in a sample, it is not identifiable as such.
This DNA or RNA must be amplified (multiplied) a certain number of times , sometimes a very large number of times, before it can be detected. From a minute trace, up to billions of copies of a specific sample can be obtained, but this does not mean that there is all that amount in the organism being tested.
In the case of COVID-19, the element sought by RT-PCR is SARS-CoV-2, an RNA virus [8].
There are DNA viruses such as Herpes and Varicella viruses.
The most well known RNA viruses , in addition to coronaviruses, are Influenza, Measles, EBOLA, ZIKA viruses.
In the case of SARS-CoV-2, RNA virus, an additional specific step is required, a transcription of RNA into DNA by means of an enzyme, Reverse Transcriptase.
This step precedes the amplification phase.
It is not the whole virus that is identified, but sequences of its viral genome.
This does not mean that this gene sequence, a fragment of the virus, is not specific to the virus being sought, but it is an important nuance nonetheless:
RT-PCR does not reveal any virus, but only parts, specific gene sequences of the virus.
At the beginning of the year, the SARS-CoV-2 genome was sequenced.
It consists of about 30,000 base pairs. The nucleic acid (DNA-RNA), the component of the genes, is a sequence of bases. In comparison, the human genome has more than 3 billion base pairs.
Teams are continuously monitoring the evolution of the SARS-CoV-2 viral genome as it evolves [9-10-11], through the mutations it undergoes. Today, there are many variants [12].
By taking a few specific genes from the SARS-CoV-2 genome, it is possible to initiate RT-PCR on a sample from the respiratory tract.
For COVID-19 disease, which has a nasopharyngeal (nose) and oropharyngeal (mouth) entry point, the sample should be taken from the upper respiratory tract as deeply as possible in order to avoid contamination by saliva in particular.
ll the people tested said that it is very painful [13].
The Gold Standard (preferred site for sampling) is the nasopharyngeal (nasal) approach , the most painful route.
If there is a contraindication to the nasal approach, or preferably to the individual being tested, depending on the official organs, the oropharyngeal approach (through the mouth) is also acceptable. The test may trigger a nausea/vomiting reflex in the individual being tested.
Normally, for the result of an RT-PCR test to be considered reliable, amplification from 3 different genes (primers) of the virus under investigation is required .
"The primers are single-stranded DNA sequences specific to the virus. They guarantee the specificity of the amplification reaction. " [14]
"The first test developed at La Charité in Berlin by Dr. Victor Corman and his associates in January 2020 allows to highlight the RNA sequences present in 3 genes of the virus called E, RdRp and N . To know if the sequences of these genes are present in the RNA samples collected, it is necessary to amplify the sequences of these 3 genes in order to obtain a signal sufficient for their detection and quantification. "[15].
The essential notion of Cycle Time or Cycle Threshold or Ct positivity threshold [16].
An RT-PCR test is negative (no traces of the desired element) or positive (presence of traces of the desired element).
However, even if the desired element is present in a minute, negligible quantity, the principle of RT-PCR is to be able to finally highlight it by continuing the amplification cycles as much as necessary.
RT-PCR can push up to 60 amplification cycles, or even more!
Here is how it works:
Cycle 1: target x 2 (2 copies)
Cycle 2: target x 4 (4 copies)
Cycle 3: target x 8 (8 copies)
Cycle 4: target x 16 (16 copies)
Cycle 5; target x 32 (32 copies)
Etc exponentially up to 40 to 60 cycles!
When we say that the Ct (Cycle Time or Cycle Threshold or RT-PCR positivity threshold) is equal to 40, it means that the laboratory has used 40 amplification cycles , i.e. obtained 2 40 copies.
This is what underlies the sensitivity of the RT-PCR assay.
While it is true that in medicine we like to have high specificity and sensitivity of the tests to avoid false positives and false negatives, in the case of COVID-19 disease, this hypersensitivity of the RT-PCR test caused by the number of amplification cycles used has backfired.
This over-sensitivity of the RT-PCR test is deleterious and misleading!
It detaches us from the medical reality which must remain based on the real clinical state of the person: is the person ill, does he or she have symptoms?
That is the most important thing!
As I said at the beginning of the article, in medicine we always start from the person: we examine him/her, we collect his/her symptoms (complaints-anamnesis) and objective clinical signs (examination) and on the basis of a clinical reflection in which scientific knowledge and experience intervene, we make diagnostic hypotheses.
Only then do we prescribe the most appropriate tests, based on this clinical reflection.
We constantly compare the test results with the patient's clinical condition (symptoms and signs), which takes precedence over everything else when it comes to our decisions and treatments.
Today, our governments, supported by their scientific safety advice, are making us do the opposite and put the test first, followed by a clinical reflection necessarily influenced by this prior test, whose weaknesses we have just seen, particularly its hypersensitivity.
None of my clinical colleagues can contradict me.
Apart from very special cases such as genetic screening for certain categories of populations (age groups, sex) and certain cancers or family genetic diseases, we always work in this direction: from the person (symptoms, signs) to the appropriate tests, never the other way around.
This is the conclusion of an article in the Swiss Medical Journal (RMS) published in 2007, written by doctors Katia Jaton and Gilbert Greub microbiologists from the University of Lausanne :
PCR in microbiology: from DNA amplification to result interpretation :
"To interpret the result of a PCR, it is essential that clinicians and microbiologists share their experiences, so that the analytical and clinical levels of interpretation can be combined."
It would be indefensible to give everyone an electrocardiogram to screen everyone who might have a heart attack one day.
On the other hand, in certain clinical contexts or on the basis of specific evocative symptoms, there, yes, an electrocardiogram can be beneficial.
Back to RT-PCR and Ct (Cycle Time or Cycle Threshold).
In the case of an infectious disease, especially a viral one, the notion of contagiousness is another important element.
Since some scientific circles consider that an asymptomatic person can transmit the virus, they believe it is important to test for the presence of virus, even if the person is asymptomatic, thus extending the indication of RT-PCR to everyone.
Are RT-PCR tests good tests for contagiousness? [17]
This question brings us back to the notion of viral load and therefore Ct .
The relationship between contagiousness and viral load is disputed by some people [18] and no formal proof, to date, allows us to make a decision.
However, common sense gives obvious credence to the notion that the more virus a person has inside him or her , especially in the upper airways (oropharynx and nasopharynx), with symptoms such as coughing and sneezing, the higher the risk of contagiousness , proportional to the viral load and the importance of the person's symptoms.
This is called common sense , and although modern medicine has benefited greatly from the contribution of science through statistics and Evidence-Based Medicine (EBM), it is still based primarily on common sense, experience and empiricism.
Medicine is the art of healing .
No test measures the amount of virus in the sample!
RT-PCR is qualitative : positive (presence of the virus) or negative (absence of the virus).
This notion of quantity, therefore of viral load, can be estimated indirectly by the number of amplification cycles (Ct) used to highlight the virus sought.
The lower the Ct used to detect the virus fragment, the higher the viral load is considered to be (high).
The higher the Ct used to detect the virus fragment, the lower the viral load is considered to be (low).
Thus, the French National Reference Centre (CNR), in the acute phase of the pandemic, estimated that the peak of viral shedding occurred at the onset of symptoms, with an amount of virus corresponding to approximately 10 8 (100 million) copies of SARS-CoV-2 viral RNA on average (French COVID-19 cohort data) with a variable duration of shedding in the upper airways (from 5 days to more than 5 weeks) [19].
This number of 108 (100 million) copies/μl corresponds to a very low Ct.
A Ct of 32 corresponds to 10-15 copies/μl.
A Ct of 35 corresponds to about 1 copy/μl.
Above Ct 35, it becomes impossible to isolate a complete virus sequence and culture it!
In France and in most countries, Ct levels above 35, even 40, are still used even today!
The French Society of Microbiology (SFM) issued an opinion on September 25, 2020 in which it does not recommend quantitative results, and it recommends to make positive up to a Ct of 37 for a single gene [20]!
With 1 copy/μl of a sample (Ct 35) , without cough, without symptoms, one can understand why all these doctors and scientists say that a positive RT-PCR test means nothing , nothing at all in terms of medicine and clinic!
Positive RT-PCR tests, without any mention of Ct or its relation to the presence or absence of symptoms, are used as is by our governments as the exclusive argument to apply and justify their policy of severity, austerity, isolation and aggression of our freedoms, with the impossibility to travel, to meet, to live normally!
There is no medical justification for these decisions, for these governmental choices!
In an article published on the website of the New York Times (NYT) on Saturday, August 29, American experts from Harvard University are surprised that RT-PCR tests as practiced can serve as tests of contagiousness, even more so as evidence of pandemic progression in the case of SARS-CoV-2 infection [21].
The Covid-19 Numbers Game: The "Second Wave" is Based on Fake StatisticsAccording to them, the threshold (Ct) considered results in positive diagnoses in people who do not represent any risk of transmitting the virus!
The binary "yes/no" answer is not enough, according to this epidemiologist from the Harvard University School of Public Health.
"It's the amount of virus that should dictate the course of action for each patient tested. "
The amount of virus (viral load); but also and above all the clinical state, symptomatic or not of the person!
This calls into question the use of the binary result of this RT-PCR test to determine whether a person is contagious and must follow strict isolation measures.
These questions are being raised by many physicians around the world, not only in the United States but also in France, Belgium ( Belgium Health Experts Demand Investigation Of WHO For Faking Coronavirus Pandemic ), France, Germany, Italy, the United Kingdom, the United States and the United Kingdom. in Germany, Spain
According to them: " We are going to put tens of thousands of people in confinement, in isolation, for nothing. " [22]. 22] And inflict suffering, anguish, economic and psychological dramas by the thousands!
Most RT-PCR tests set the Ct at 40, according to the NYT. Some set it at 37.
"Tests with such high thresholds (Ct) may not only detect live virus but also gene fragments, remnants of an old infection that do not represent any particular danger," the experts said.
A virologist at the University of California admits that an RT-PCR test with a Ct greater than 35 is too sensitive. " A more reasonable threshold would be between 30 and 35, " she adds.
Almost no laboratory specifies the Ct (number of amplification cycles performed) or the number of copies of viral RNA per sample μl.
Here is an example of a laboratory result (approved by Sciensano, the Belgian national reference center) in an RT-PCR negative patient:
No mention of Ct.
In the NYT, experts compiled three datasets with officials from the states of Massachusetts, New York and Nevada that mention them.
Conclusion?
" Up to 90% of the people who tested positive did not carry a virus. "
The Wadworth Center, a New York State laboratory, analyzed the results of its July tests at the request of the NYT: 794 positive tests with a Ct of 40.
" With a Ct threshold of 35 , approximately half of these PCR tests would no longer be considered positive ," said the NYT.
"And about 70% would no longer be considered positive with a Ct of 30 ! "
In Massachusetts, between 85 and 90% of people who tested positive in July with a Ct of 40 would have been considered negative with a Ct of 30, adds the NYT. And yet, all these people had to isolate themselves, with all the dramatic psychological and economic consequences, while they were not sick and probably not contagious at all.
In France, the Centre National de Référence (CNR), the French Society of Microbiology (SFM) continue to push Ct to 37 and recommend to laboratories to use only one gene of the virus as a primer.
I remind you that from Ct 32 onwards, it becomes very difficult to culture the virus or to extract a complete sequence, which shows the completely artificial nature of this positivity of the test, with such high Ct levels, above 30.
Similar results were reported by researchers from the UK Public Health Agency in an article published on August 13 in Eurosurveillance : " The probability of culturing the virus drops to 8% in samples with Ct levels above 35." [23]
In addition, currently, the National Reference Center in France only evaluates the sensitivity of commercially available reagent kits, not their specificity: serious doubts persist about the possibility of cross-reactivity with viruses other than SARS-CoV-2, such as other benign cold coronaviruses. [20]
It is potentially the same situation in other countries, including Belgium.
Similarly, mutations in the virus may have invalidated certain primers (genes) used to detect SARS-CoV-2: the manufacturers give no guarantees on this, and if the AFP fast-checking journalists tell you otherwise, test their good faith by asking for these guarantees, these proofs.
If they have nothing to hide and if what I say is false, this guarantee will be provided to you and will prove their good faith.
- We must demand that the RT-PCR results be returned mentioning the Ct used because beyond Ct 30, a positive RT-PCR test means nothing.
- We must listen to the scientists and doctors, specialists, virologists who recommend the use of adapted Ct, lower, at 30 . An alternative is to obtain the number of copies of viral RNA/μl or /ml sample. [23]
- We need to go back to the patient, to the person, to his or her clinical condition (presence or absence of symptoms) and from there to judge the appropriateness of testing and the best way to interpret the result.
Until there is a better rationale for PCR screening, with a known and appropriate Ct threshold, an asymptomatic person should not be tested in any way.
Even a symptomatic person should not automatically be tested, as long as they can place themselves in isolation for 7 days.
Let's stop this debauchery of RT-PCR testing at too high Ct levels and return to clinical, quality medicine.
Once we understand how RT-PCR testing works, it becomes impossible to let the current government routine screening strategy, inexplicably supported by the virologists in the safety councils, continue.
My hope is that, finally, properly informed, more and more people will demand that this strategy be stopped , because it is all of us, enlightened, guided by real benevolence and common sense, who must decide our collective and individual destinies.
No one else should do it for us, especially when we realize that those who decide are no longer reasonable or rational.
Summary of important points :
- The RT-PCR test is a laboratory diagnostic technique that is not well suited to clinical medicine.
- It is a binary, qualitative diagnostic technique that confirms (positive test) or not (negative test) the presence of an element in the medium being analyzed. In the case of SARS-CoV-2, the element is a fragment of the viral genome, not the virus itself.
- In medicine, even in an epidemic or pandemic situation, it is dangerous to place tests, examinations, techniques above clinical evaluation (symptoms, signs). It is the opposite that guarantees quality medicine.
- The main limitation (weakness) of the RT-PCR test, in the current pandemic situation, is its extreme sensitivity (false positive) if a suitable threshold of positivity (Ct) is not chosen. Today, experts recommend using a maximum Ct threshold of 30.
- This Ct threshold must be informed with the positive RT-PCR result so that the physician knows how to interpret this positive result, especially in an asymptomatic person, in order to avoid unnecessary isolation, quarantine, psychological trauma.
- In addition to mentioning the Ct used, laboratories must continue to ensure the specificity of their detection kits for SARS-CoV-2, taking into account its most recent mutations, and must continue to use three genes from the viral genome being studied as primers or, if not, mention it.
Overall Conclusion
Is the obstinacy of governments to use the current disastrous strategy, systematic screening by RT-PCR, due to ignorance?
Is it due to stupidity?
To a kind of cognitive trap trapping their ego?
In any case, we should be able to question them, and if among the readers of this article there are still honest journalists, or naive politicians, or people who have the possibility to question our rulers, then do so, using these clear and scientific arguments.
It is all the more incomprehensible that our rulers have surrounded themselves with some of the most experienced specialists in these matters.
If I have been able to gather this information myself, shared, I remind you, by competent people above all suspicion of conspiracy, such as Hélène Banoun, Pierre Sonigo, Jean-François Toussaint, Christophe De Brouwer, whose intelligence, intellectual honesty and legitimacy cannot be questioned, then the Belgian, French and Quebec scientific advisors, etc., know all this as well.
So?
What's going on?
Why continue in this distorted direction, obstinately making mistakes?
It is not insignificant to reimpose confinements, curfews, quarantines, reduced social bubbles, to shake up again our shaky economies, to plunge entire families into precariousness, to sow so much fear and anxiety generating a real state of post-traumatic stress worldwide, to reduce access to care for other pathologies that nevertheless reduce life expectancy much more than COVID-19! [24]
Is there intent to harm?
Is there an intention to use the alibi of a pandemic to move humanity towards an outcome it would otherwise never have accepted? In any case, not like that!
Would this hypothesis, which modern censors will hasten to label "conspiracy", be the most valid explanation for all this?
Indeed, if we draw a straight line from the present events, if they are maintained, we could find ourselves once again confined with hundreds, thousands of human beings forced to remain inactive, which, for the professions of catering, entertainment, sales, fairgrounds, itinerants, canvassers, risks being catastrophic with bankruptcies, unemployment, depression, suicides by the hundreds of thousands. [25-26-27-28]
The impact on education, on our children, on teaching, on medicine with long planned care, operations, treatments to be cancelled, postponed, will be profound and destructive.
"We risk a looming food crisis if action is not taken quickly." [29].
It is time for everyone to come out of this negative trance, this collective hysteria , because famine, poverty, massive unemployment will kill, mow down many more people than SARS-CoV-2!
Does all this make sense in the face of a disease that is declining, over-diagnosed and misinterpreted by this misuse of overly sensitively calibrated PCR tests?
For many, the continuous wearing of the mask seems to have become a new norm.
Even if it is constantly downplayed by some health professionals and fact-checking journalists, other doctors warn of the harmful consequences, both medical and psychological, of this hygienic obsession which, maintained permanently, is in fact an abnormality!
What a hindrance to social relations, which are the true foundation of a physically and psychologically healthy humanity!
Some dare to find all this normal, or a lesser price to pay in the face of the pandemic of positive PCR tests.
Isolation, distancing, masking of the face, impoverishment of emotional communication, fear of touching and kissing even within families, communities, between relatives
Spontaneous gestures of daily life hindered and replaced by mechanical and controlled gestures
Terrified children, kept in permanent fear and guilt
All this will have a deep, lasting and negative impact on human organisms, in their physical, mental, emotional and representation of the world and society.
This is not normal!
We cannot let our rulers, for whatever reason, organize our collective suicide any longer.
Translated from French by Global Research. Original source: Mondialisation.ca
Dr Pascal Sacré is a physician specialized in critical care, author and renowned public health analyst, Charleroi, Belgium. He is a Research Associate of the entre for Research on Globalization (CRG)
****
Professionals whose references and comments are the basis of this article in its scientific aspect (especially and mainly on RT-PCR):
1) Hélène Banoun
https://www.researchgate.net/profile/Helene_Banoun
PhD, Pharmacist biologist
Former INSERM Research Officer
Former intern at the Paris Hospitals
2) Pierre Sonigo
Virologist
Research Director INSERM, worked at the Pasteur Institute
Heads the Virus Genetics Laboratory in Cochin, Paris.
Participated in 1985 in the sequencing of the AIDS virus.
3) Christophe De Brouwer
PhD in Public Health Science
Honorary Professor at the School of Public Health at ULB, Belgium
4) Jean-François Toussaint
Doctor, Professor of Physiology at the University of Paris-Descartes
Director of IRMES, Institute for BioMedical Research and Sports Epidemiology
Former member of the High Council of Public Health
***
Jan 21, 2021 | www.zerohedge.com
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xpxhxoxexnxixx 7 hours ago (Edited) remove link
Give Me Some Truth 6 hours ago (Edited)The short answer to both of these questions regarding the COVID-19 'casedemic' and the fallacy of asymptomatic PCR testing is YES and YES!
The only answer was always yes. No one should be surprised that everyone in the political 'health sector' managed to delay or ignore any real science , not in the name of the truth mind you, but because of their opposition to the administration.
That's right, there's really no other way to put it. We had initial science, which in any movie script would have been that one moment where the 'nobody' scientist gets called into the Whitehouse to explain his life saving discovery. Instead, in our reality, those scientists were ridiculed and told they were either wrong, or the science wasn't accurate enough (never mind wanting to further support it so we could confirm or deny). These people played games in hopes of running out the clock.
Put yourself in an alternate role- if you were in a position to make official guidelines and recommendations and you realized there was science (mind you, people that spend their careers doing this) that said 'there is a good probability that doing xyz will save a life'..would you decide not to explore it? Would you decide not to share it with others?
Wonder what would have happened if let's say, the 'pandemic' would have occurred two years into presidency instead of the last 3/4 of it. Just throwing that out there for thought.
Now, when the dust settles, suddenly the WHO, Fauci and everyone else is willing to admit the science. I guess better late than never.
Demologos 6 hours ago remove linkPlus, "new cases" are almost certainly going to plummet on their own . Reasons: We will soon leave the "cold land flu" season, fewer people will be tested, and the number of people who have already contracted the virus continues to grow. This means that the pool of people who could test positive in the future will be much smaller (because people who have already had the virus now have acquired natural immunity).
Bottom line: The coming huge decline in "new cases" will almost assuredly have nothing to do with the number of people who have received both doses of the vaccine.
Ajax_USB_Port_Repair_Service_ 8 hours ago (Edited)Masks are great for spreading viruses and bacterial infections unless strict protocols are followed. Remember last year when every news report on Covid ended with a segment on mask hygiene and proper fitting? Me neither.
Luci Feric 8 hours agoThe CT will be lowered AFTER 100 days of masks and then the Biden miracle happens.
Ajax_USB_Port_Repair_Service_ 8 hours ago* miracle
You're welcome!
Luci
Luci Feric 8 hours agoThank you Luci. I knew that didn't look right.
karzai_luver 9 hours agoYou're welcome!
dark pools of soros 9 hours agoThe WHO/NIH/CDC are political grifters.
The leaderships are political hacks.
Why they still have any cred is unreal.
They have been late wrong and lie forever.
The examples are too numerous to post here.
crow1234 9 hours agosame reason people still eat fast food... the flashy marketing
Give Me Some Truth 9 hours agoHere's my surprised face 😮
F all this ****!
tangent 9 hours agoExcellent analysis and kudos for highlighting the key role of the PCR tests in establishing the narrative.
However, the key reason the PCR tests WILL be changed was not mentioned: This HAS to happen to "prove" that the vaccines "work."
Once the PCR tests are changed, cases will plummet by 90 percent. The "miracle vaccines" will get all the credit.
More importantly, by changing the PCR tests t his precludes the possibility of large numbers of people "testing positive" AFTER receiving two doses of the vaccine. This would not be good for the old credibility and trust of authorities and "public health officials" who have been pushing mass vaccination.
P.S. I still wonder if the tens of thousands of people in the vaccine trial weren't tested with PCR tests that had already been "adjusted." This would explain those "95 percent effective" claims.
That is likely all true, but it has the ridiculous flaw of people with the vaccine still getting the same positive rates as those without the vaccine. Very funny! But then again, people don't seem to snap into reality when they learn the population is still going up same as last year and the year before that... very foolish thinking to think that is a pandemic.
Jan 21, 2021 | www.zerohedge.com
Right On Cue For Biden, WHO Admits High-Cycle PCR Tests Produce COVID False Positives BY TYLER DURDEN THURSDAY, JAN 21, 2021 - 6:30
Were the 'conspiracy theorists' just proven right about the "fake rescue plan" for COVID? Did the 'science-deniers' just get confirmation that it was political after all ? The short answer to both of these questions regarding the COVID-19 'casedemic' and the fallacy of asymptomatic PCR testing is YES and YES!
We have detailed the controversy surrounding America's COVID "casedemic" and the misleading results of the PCR test and its amplification procedure in great detail over the past few months. As a reminder, "cycle thresholds" (Ct) are the level at which widely used polymerase chain reaction (PCR) test can detect a sample of the COVID-19 virus. The higher the number of cycles, the lower the amount of viral load in the sample; the lower the cycles, the more prevalent the virus was in the original sample.
Numerous epidemiological experts have argued that cycle thresholds are an important metric by which patients, the public, and policymakers can make more informed decisions about how infectious and/or sick an individual with a positive COVID-19 test might be. However, as JustTheNews reports, health departments across the country are failing to collect that data .
In fact, as far back as October, we brought the world's attention to the COVID-19 "casedemic" and the disturbing reality of high-cycle threshold PCR tests being worse than useless as indicators of COVID-19 "sickness". PJMedia's Stacey Lennox said at the time:
Biden will issue national standards, like the plexiglass barriers in restaurants he spoke about during the debate, and pressure governors to implement mask mandates using the federal government's financial leverage.
Some hack at the CDC or FDA will issue new guidance lowering the Ct the labs use , and cases will magically start to fall.
In reality, the change will only eliminate false positives, but most Americans won't know that.
Good old Uncle Joe will be the hero, even though it is Deep-State actors in the health bureaucracies who won't solve a problem with testing they have been aware of for months. TDS is a heck of a drug.
https://lockerdome.com/lad/13084989113709670?pubid=ld-dfp-ad-13084989113709670-0&pubo=https%3A%2F%2Fwww.zerohedge.com&rid=www.zerohedge.com&width=830
And now, as Lennox explains in detail below, we have been proved 100% correct as less than one hour after President Biden's inauguration, the WHO proved us right .
In August of last year, The New York Times published an article stating that as many as 90% of COVID-19 tests in three states were not indicative of active illness . In other words, they were picking up viral debris incapable of causing infection or being transmitted because the cycle threshold (Ct) of the PCR testing amplified the sample too many times.
Labs in the United States were using a Ct of 37-40. Epidemiologists interviewed at the time said a Ct of around 30 was probably more appropriate. This means the CDC's COVID-19 test standards for the PCR test would pick up an excessive number of false positives. The Times report noted the CDC's own data suggested the PCR did not detect live virus over a Ct of 33. The reporter also noted that clinicians were not receiving the Ct value as part of the test results.
Yet a PCR test instruction document from the CDC that had been revised five times as of July 13, 2020 , specified testing and interpretation of the test using a Ct of 40. On September 28, 2020, a study published in the journal Clinical Infectious Diseases from Jaafar et al. had asserted, based on patient labs and clinical data involving nearly 4,000 patients, that a Ct of 30 was appropriate for making public policy. An update to the CDC instructions for PCR testing from December 1, 2020 , still uses a Ct of 40.
Shortly before the New York Times article was published, the CDC revised its COVID-19 test recommendations , saying that only syptomatic patients should be tested . The media went insane, and Dr. Fauci went all over television saying he was not part of the decision to change the testing standards:
"I am concerned about the interpretation of these recommendations and worried it will give people the incorrect assumption that asymptomatic spread is not of great concern. In fact it is."
So, of course, the Mendacious Midget™ had spoken, and the guidelines went back to testing everyone, all the time, with an oversensitive test.
The idea that asymptomatic spread was a concern as of August was just one of many lies Dr. Fauci told. At the beginning of the pandemic in late January, he said:
The one thing historically that people need to realize is that even if there is some asymptomatic transmission, in all the history of respiratory borne viruses of any type, asymptomatic transmission has never been the driver of outbreaks. The driver of outbreaks is always a symptomatic person. Even if there is a rare asymptomatic person that might transmit, an epidemic is not driven by asymptomatic carriers.
There is not a single study or meta-analysis that differs from Fauci's original assessment.
Today, within an hour of Joe Biden being inaugurated and signing an executive order mandating masks on all federal property, the WHO sent out a notice to lab professionals using the PCR test . It said:
WHO guidance Diagnostic testing for SARS-CoV-2 states that careful interpretation of weak positive results is needed ( 1 ).
The cycle threshold (Ct) needed to detect virus is inversely proportional to the patient's viral load.
Where test results do not correspond with the clinical presentation, a new specimen should be taken and retested using the same or different NAT technology.
literally one hour after Biden takes the oath, the WHO admits that PCR testing at high amplification rates alters the predictive value of the tests and results in a huge number of false positives pic.twitter.com/iDtXmappRw
-- Andy Swan (@AndySwan) January 20, 2021This translates to "in the absence of symptoms, a high Ct value means you are highly unlikely to become ill or get anyone else sick in the absence of very recent exposure to an infected person."
Dr. Fauci knew this in July when he said that tests with a Ct above 35 were likely picking up viral debris or dead virus .
Even at a Ct of 35, the incidence of virus samples that could replicate is very low, according to Jaafar et al.
The only state I know that requires reporting the Ct with every test is Florida, which started this policy in December .
The WHO went on, stating:
Most PCR assays are indicated as an aid for diagnosis, therefore, health care providers must consider any result in combination with timing of sampling, specimen type, assay specifics, clinical observations, patient history, confirmed status of any contacts, and epidemiological information.
In short, a positive PCR test in the absence of symptoms means nothing at a Ct of higher than 30, according to the experts interviewed by the New York Times and according to Jaafar et al. Yet positive tests is the number CNN loves flashing on the screen.
If the percentage found by the Times in August holds, there have been approximately 2.43 million actual cases to date, not 24.3 million.
There is also no way to calculate the deaths from COVID-19 rather than deaths with some dead viral debris in the nostrils.
What I have referred to as the "casedemic" since September will be magically solved just in time for Joe Biden to look like a hero. For doing absolutely nothing.
Do not tell me there is not a politicized deep state in our health agencies. Do not ever tell me I need to listen to Dr. Anthony Fauci again. And every business owner who has been ruined because of lockdowns due to a high number of "cases" should be livid. Any parent whose child has lost a year of school should be furious.
None of this was for your health. It was to get rid of Orange Man Bad.
now they will drop the cycle rates and you can watch the curve go negative... like magic... because the new magic man isn't the bad man and the masks he ordered worked!!!!!
-- Andy Swan (@AndySwan) January 20, 2021As an aside, this also clearly explains the disappearance of the "flu" during this season as the plethora of high Ct PCR Tests supposedly pointing to a surge in COVID are nothing of the sort.
As Stephen Lendman noted previously , claiming "lockdowns stopped flu in its tracks, (outbreaks) plummet(ting) by 98% in the United States" ignored that what's called COVID is merely seasonal influenza combined with false positives (extremely high Ct) from PCR-Tests.
And for that reason, the great 2020 disappearing flu passes largely under the mass media's radar. Media proliferated mass deception and the power of repetition get most people to believe and having successfully "killed the flu", they will now do the same with COVID... and, if allowed by our betters, we will all return to the new normal they desire.
Give Me Some Truth 5 hours ago remove link
philipat 9 hours agoThe governor of Florida has proposed a law that is ingenious, or at least very important (if passed). He simply wrote into his proposed bill that labs have to disclose the cT levels in all "positive" COVID results.
He obviously put this language in the bill/regulations because he knew "public health officials" would try to continue to conceal this information.
If this law is enacted, we will learn WHEN the PCR tests were adjusted . We will then be able to see how the number of "positive cases" changes (read: declines significantly).
Here's hoping this law is enacted (with no loopholes) ... and that many more states enact the same legislation.
Fed-up with being Sick and Tired 7 hours agoLoved that banner at the Vienna protest last weekend "Make Infuenza Great Again"
Boing_Snap 6 hours ago...The CT standards have been all over the place and inconsistent. It became quite clear to my family and myself when we started readin: "ASYMPTOMATIC COVID cases surge" MONTHS AGO!
The smartest little kid in our family, a young Girl at age 15 and is a BIG fan of Biology and has decided that Virology will be her studies in college, said: "Daddy, is there a disease if there are no symptoms?"
NO ONE AROUND THE TABLE had a clear answer. There were attempts and then the press started talking: "YOU CAN CARRY COVID and not know it, so wear a mask!!!"
The ludicrous nature this entire charade started to unfold! SO, 40 degrees, you are not stupid, just ignorant of the facts.
Go out and do your own homework before you continue to act like an expert in Virology. YOU ARE NOT. We are all bystanders to a fraud perpetrated for nefarious reasons.
Oceania2020 6 hours ago (Edited)Educated people know that these Tests were fake, the propaganda used was not for our consumption, just the masses whom are only looking at headlines, which is the majority of humanity.
Putting the manipulation of the tests together with a, heavens forbid a "Conspiracy Theory", kept the indoctrinated away from looking at it. So now that is changing, good.
The Indoctrinated are most of the population, they range across the spectrum, scholars and professionals included. Getting them to think for themselves will not be easy.
checkessential 4 hours agoSome of the dumbest words ever spoken...
"Google it".
meowmix105 6 hours ago (Edited)At least FB and Twitter will prove that whatever you Google is true regardless of the facts.
xpxhxoxexnxixx 5 hours agoYou imbicile, here's a link along with the first two paragraphs from article_ https://www.10news.com/news/local-news/san-diego-county-very-likely-flu-shots-covid-19-measures-keeping-influenza-cases-low
"So far this season, the county has recorded 39 influenza cases, compared to 1,220 cases at this point last season. Flu season generally runs from October through May, with flu activity peaking in December and February. The county says it's "very likely" physical distancing, hand washing, and mask-wearing are contributing to the low flu activity".
As Fed-up with being Sick and Tired stated - you've got to be absolutely clueless and or completely ignorant to not see these idiotic and contradictory statements by the San Diego county health dept.....
When the noble coronavirus is the common flu virus to begin with! Yet, there's record number of people getting covid all while having historically low cases of the flu _ thanks to the masks! 🤯🤯 wake up ffs
MrBoompi 4 hours agoSo then how would you explain the inability for the WHO, Fauci and anyone else in that club not using the publicly available data since April, as you said, and revising the way we test and measure 'cases'? Biden would never go against the media lol so unless you have a link gtfo.
Ophiuchus PREMIUM 9 hours agoThis is a straw man argument. No diagnostic test like this is 100% accurate and nobody would ever make such a stupid claim. But what if someone had, accurately, stated that the pcr test is 5% accurate?
THIS IS TRUE
Dash8 6 hours agoDo you think they will admit Building 7 was a controlled demolition?
Ophiuchus PREMIUM 9 hours ago (Edited)There's nothing left of it, it was all shipped to china with the rest of the evidence...
Suzy Q 8 hours agoDo you think they will admit that powerful politicians in America are controlled by sex with young children?
They will never admit to anything.
All politicians in positions of power, rape and murder children. Lin Wood knows. Start there.............
"Referring to Speaker of the House Dennis Hastert as a "serial child molester", a federal judge imposed a sentence of 15 months in prison, two years' supervised release, and a $250,000 fine. Hastert was imprisoned in 2016 and was released 13 months later." --- Why not 15 years? When politicians in D.C. get caught raping children, it's a slap on the wrist.
JRobby 7 hours ago (Edited)I have not researched this at all and cannot verify any of it, but here it is
https://steverotter.com/arrests-and-executions-of-famous-people-2020/
Except, I have looked at the part about wrinkled flags. I can only go so far down the rabbit hole before I have to stop.
Suzy Q 2 hours agoYea, just post it anyway. You are probably safe in a secure area.
There are at least 7 or 8 major Psy Ops running right now not to mention hundreds of minor ones.
daveO 30 minutes ago (Edited)There are things that cannot be unseen and I'd prefer not to see those things.
Livingston 7 minutes ago"G5 said many other people are going to face justice, but only one will have a public trial -- John Brennan, the Anti-Trump American intelligence official who served as the Director of the CIA from March 2013 to January 2017. He will have a public trial, and if convicted, will be hanged."
If so, I hope the hanging is televised.
"Some find it difficult to believe that McCain and GHWB were executed. What is the point of killing a dying person?
The point is they cannot escape by retiring, resigning or living out. What they have done remains, and their families are also demonized. The audience is SPECIFICALLY for DEEP STATE."This would explain Beijing Biden's inauguration with 200K flags and no civilians.
daveO 38 minutes agoA Pay-Per-View of John Brennan being hanged would be a huge money maker. Could probably balance the budget singlehandedly!
philipat 8 hours agoBingo! It's why Hunter fled Delaware to marry a "movie producer" in May, 2019.
Hal n back 7 hours ago (Edited)No, that's not how these things work. You NEVER admit anything, just bury the facts, censor as much as possible (to control the narrative) and stick to the official narrative always no matter how discredited or ridiculous it may be. In fact, the strategy is "If you can't win the debate don't have the debate".
And BTW, not only Building 7
Dear Old Hedge 6 hours agoLook at your car insurance card. After an accident, do not admit you were wrong.
for that, because of frivilous lawsuts there ends up being unnecessary settlement by insurers to avoid trial.
the plaintiffs and attys usually avoid a counter suit so they have no problem
The legal system has many issues.
and congress has a lot of lawyers.
JethroBodine_ 5 hours ago (Edited)And the others may have been George Lucas's Industrial Light & Magic, or Project Blue Beam, or something related: https://newspunch.com/cia-pilot-presents-evidence-that-no-planes-hit-towers-on-911/
Would anything really surprise anyone at this point?
systemsplanet 8 hours agoNever ever believe anything the CIA says. Everything they say is a limited hangout.
Planes hit the towers but certainly were not the cause of three sky scrappers falling at near free fall speed, symmetrically and into their own footprint.
That said, a jumbo jet did not hit the pentagon!
deadcat2 8 hours agoOne day people who rushed out to inject the covid vaccine will begin to question what the hell they just injected in their arm.
prairie oysters PREMIUM 7 hours agoThe kind of sheep that do that are the sort that complain if there are no lamb chops for dinner.
Giant Meteor 6 hours agoThere is (I hope) a very clever metaphor buried in "lamb chops."
SwmngwShrks 5 hours agoLambs get slaughtered .. eaten
Or placed in petting zoos
JRobby 7 hours agoIts a Simpsons reference..."D'Oh!"
GreatUncle 7 hours agoNo THEY won't
EVER
Same reason they do this totally obvious $h!t.
Sick Monkey 7 hours agoWe can only hope we get too hang people for the "intentional" 1st degree murder of 1000's.
Marla Singer 9 hours agoThe flu is one of many infectious diseases. It's like we traveled through space and landed on a planet that has only two infectious diseases. They focus on those two like some sort of marketing campaign. A gold mine for big tech. Get your shot today! Call now and we'll throw in another 2 of your choice. Buy one and get another two for free. Limited time offer.
camel717 6 hours agoWhen you think about the lengths the permanent fusion party had to go to to get their candidate over the finish line: constant media bombardment against Trump, nation wide lockdowns, social media blackouts, election fraud, false flag events, and a militarized inauguration, I have to imagine it's a pretty fragile win.
Iron Lady 1 hour agoThis is what I've been trying to tell people. After everything the democrats, celebrities pandering, media etc. did to keep Trump out, as well as the mail in ballots (which, if didn't happen, Trump would've won in a landslide) did to help Biden win, he barely ******* won. HE BARELY WON.
It was made out to look like the entire world was against Trump and he still won sans fraud and mail in ballots.
The future isn't as bleak as people think. There will be another red wave in 2022 I suspect, unless mail ins continue to be the norm which democrats certainly will try because it's their only path to victory at this point.
Cautiously Pessimistic 9 hours agoXiden's inauguration video on commietube had 16,000 down votes and 4,000 up votes last I checked. The views were very low.
Trump's farewell at Andrews had 800,000 views in real time at RSBN.
Crash N. Burn 8 hours agoIt has not even been a full 24hrs since Biden was sworn in and already the shenanigans have started. Once again, Trump, his administration and that small part of the press that still has journalistic integrity is proven right. This was predicted. It will be interesting to see what else moves from the conspiracy theory to the CONSPIRACY FACT column over the next days and weeks.
Ophiuchus PREMIUM 8 hours agoTime to file a writ of quo warranto? From constitution.org :
" A writ of quo warranto is not a petition, but a notice of demand, issued by a demandant, to a respondant claiming some delegated power, and filed with a court of competent jurisdiction, to hold a hearing within 3 to 20 days, depending on the distance of the respondant to the court, to present proof of his authority to execute his claimed powers. If the court finds the proof insufficient, or if the court fails to hold the hearing, the respondant must cease to exercise the power. If the power is to hold an office, he must vacate the office.
The writ is unlike a petition or motion to show cause, because the burden of proof is on the respondant, not on the demandant. "
Could be highly entertaining.
thunderchief 9 hours agoIt matters not as it will never be covered by the controlled media.
GreatUncle 7 hours agoScamdemic. Enough said.
Walter Melon 7 hours agoI prefer to view it as a tool.
The virus was intentionally released to create the desired effect and it was equally useful to get rid of Trump at the same time.
Still think vaccine id - digital id - digital currency and the economic lock for the globalists is the end game to usher in the great reset where everybody will be made a slave.
Even now more and more Karen's are pushing for everybody to be forced vaccinated or excluded from society where they will die a lingering economic death.
AAA 7 hours agoUp vote - who here knew this was going to happen a year ago?
Hal n back 7 hours agoNot a whole year ago but atleast a couple of months :)
vealparm 1 hour agoIt started when singapore reported its ct was 35. Not 40.
Neil Patrick Harris 9 hours agoYou can research my posts here....I was proclaiming the "ConVid-19 scam" way back in the early spring.
I am 77 and have been around the block a few times with lying lawyers and politicians, I called Fauci an actor/operative the second time I saw him and hear his spiel. The more I learned about him and his past left me with no doubt.
We have all lived a dystopian tyranny for the past year engineered by world wide hard Leftists.
Ophiuchus PREMIUM 8 hours agoSure the timing is suspect but I doubt they will suddenly lift lockdowns and let us go back to normal. This is about much more than removing Trump, it's The Great Reset.
Suzy Q 8 hours agoI call it the 'Great Extermination'.
philipat 8 hours agode Blahsio is demanding NYC reopen, as if it was the business owners that demanded the shut down. What a clown
Unknown User 1 hour agoYes agreed, Covid was a cover vehicle which allowed various different agendas to be implemented simultaneously. Primarily the Global financial Reset. And since they are still not ready with that, the covid scam will have to be extended for a good amount of time yet (At least another 12-18 months). That is why the "beaking news" about mutations to more deadly strains which will require new measures, new vaccines etc (Except that, just by magic, the existing vaccines still work just fine against the existing mutations so the vaccination campaign can continue. But they seemingly already are able to predict that the future mutant strains will not and will require new vaccines. More gravy for big pharma, more controls etc.)
OutWithLibs 7 hours ago (Edited)They want to issue electronic documents and money to control all movement and activity of the entire world.
CaMuPaSh 9 hours ago (Edited)Passed a line of cars yesterday waiting for the control vaccine. No less than 4 miles long, undoubtedly several hours in their cars. Upon completing errands I returned the same way and the line was disbursing. Apparently the county ran out of shots. People are so scared they'll wait in line for something that is not known to cure anything, caused death after injection, invented faster than any vaccine in history and has never had trials. The control is almost complete. Just add vaccination certificates to shop, buy gas, go see grandma, and the communism will be complete.
Suzy Q 8 hours agoYou know it's about over when:
Astra-Zeneca mfg. facility in India is burning down (today).
Astra-Zeneca mfg. facility in Wales is in danger of flooding (today).
Pfizer (a Rothschild Co. thanks to E. Macron) has fizzled.
Sputnik (RU) is being accepted by an increasing number of countries. EU, ME SA
Mutti Merkle is going for Sputnik.
...and the U.S.?
....a distant last.
The only thing selling in the ussa is masks (made in CN) for the next 100 days.
Oh, the days of reconciliation and roses are upon us with a vengeance.
steve golf 8 hours agoExplosion
GreatUncle 7 hours agoWho needs a vaccine really?
LA_Goldbug 6 hours agoNot a vaccine more like gene therapy if it does not use any of the viral component in it.
So you have the gene therapy but you will still catch the virus the intent is for your body to have been mutated to switch on your immune system more violently to fight it.
Thing is that response is not going to be good for some folks as the response itself puts pressure on your body just like the virus.
Virus does not kill you the symptomatic response does.
GoldmanSax 8 hours agoThe lady's English is not perfect, but the information is very valuable,
youngman 8 hours agoWe told you there was no pandemic. We kept reporting there were no deaths around us and some posters kept arguing we were covid holocaust deniers. We were right and you were a shill for an evil agenda.
The world is under attack. Most governments are onboard. Why do you need a vaccine passport for a pandemic that never happened?
Bob Lidd 8 hours agobecause of the money involved.....billions of dollars for the drug companies
steve golf 8 hours ago (Edited)it's all about control at this point.......
Cobb 8 hours agofake vaccination certificates will be easy to print. Problem is getting it on the database, if there is one, and there will be, but will airlines check the database or just look at the certificate?
toejam 2 hours agoIf only there was a digital certificate or better yet a way to insert a gel into the skin that could provide pertinent data when scanned.
pods 8 hours agoWhat are you talking about? The vaccine is to kill or maim you. How is this not understood?
buzzsaw99 8 hours agoIs anyone shocked? 100 days of diapers combined with a million or so vaccine shots and voila, gone by spring.
Nobody will hang. The machine will roll on until the next financial blowup. Then probably aliens will cause us to print 20 trillion more in debt.
We are Rome, circa 470 AD.
Indelible Scars 8 hours agoNobody will hang...
we might hang if we complain about it long enough.
NIRP-BTFD 8 hours agoIt's hard to believe that people are still falling for this AT ALL.
AlphaDawg 8 hours ago (Edited)Humanity reached peak stupidity.
GreatUncle 7 hours agoHands up, in Feb, March I was worried. An engineered P4 lab CCP virus.
By April, after saying wait for next 2 weeks a couple of times, I realised it was a complete SCAM.
Not to mention the supression of Hydroxy and airports open.
No-Go zone 6 hours agoSame ... the reality though never became what was being reported so by end of April I started having very serious doubts over it. Then the more you learned it became to obvious this was a hoax "lethal" virus although the virus may exist.
Then you find out that most who actually died were unfit overweight with existing medical condition to me implies there is a virus but not dangerous to many people.
Now the majority of the population in society because of the Karen's are now incarcerated by unfit overweight people with 2 or more comorbidities.
Lanka 9 hours ago... that sheeple ...
NIRP-BTFD 9 hours agoThe false positives of the PCR tests were known 6 months ago. Historically, ZH would have reported that in timely fashion. Another failure of ZH, cow-towing to the MSM.
deadcat2 8 hours agoZH are opportunistic money makers. They got paid of to do covid propaganda early on.
BaNNeD oN THe RuN 6 hours ago (Edited)Not true. I've read number of articles on ZH saying the PCR test was producing false positives and posters like me have been saying this from the very beginning. I suggest you read Lew Rockwell's site if you want a really good insight into the covid farce.
ImpliedVol 2 hours agoThere are multiple Tylers reporting multiple POVs.
There is "Wuhan Lab" Tyler, who was dominant at the start.
There is "Daily Case Count" Tyler (similar to MSM).
There is "Covid Conspiracy" Tyler (this article)
There are republished 3rd party blogs.Mr. Belding 6 hours agoZH has been reporting on PCR tests. The first article about it was posted in March of 2020.
Try paying attention next time.
TRM 5 hours agomasks stopped all other flu but not covid. It takes a ****** commie to believe that.
HANGTHEOWL 7 hours agoIt's the longer name man. You know that 0.1 micron "influenza" is stopped but the 0.1 micron "covid-19" isn't. It's all those extra letters in the name that masks, distancing & lockdowns work on.
uchibenkei 6 hours ago"Were the 'conspiracy theorists' just proven right about the "fake rescue plan" for COVID?"
We are not conspiracy theorists,,,we are people telling you the truth,,,,,,
Notice even when they have to admit we were right,,they try to demonize us at the same time,,,,,,
HANGTHEOWL 6 hours agoyeah. were the conspiracy theorists right? why not ask "were the mainstreamers lying this whole time?"
deadcat2 8 hours agoegg-zactly,,,,,,
Stinkbug 1 8 hours agoI'm in the UK (a cesspit on the edge of Europe) and I've been asking from the start, including emailing members of parliament, who decided that the PCR test should be amplified 45 times? Was it a government minister, some committee of scientists, or the laboratories themselves? WHO MADE THE DECISION to amplify the PCR test 45 times and why? The creator of the test, Kerry Mullis, stated that it should never be amplified more than 30 times. He even said the PCR test wasn't suitable to test for an infection either.
Had the test been limited to 30 times, there would have been next to no 'cases' as they are called and perfectly healthy people with no symptoms would not find themselves under house arrest in their millions.
Parasiticfilth 2 hours ago (Edited)And where is Kerry Mullis now, when we need him? Dead. A couple of months after exposing Fauci publicly, died at age 56 of 'pneumonia'.
HANGTHEOWL 2 hours agoSo if COVID is so contagious, why do they have to go all the way up your nasal cavity, almost to your brain to get a sample?
Shouldn't there be samples everywhere?
I mean apparently the virus spreads faster than Kamala Harris' legs.
duck_fur 2 hours agoThat is just another part of this hoax that does not make sense,,,,,,if you dig into the history of virology,,you find the same nonsense time and time again,,,,,take rabies for instance,,,they say that rabies is transmitted by the saliva of the animal when it bites you,,,,but they have to kill the animal and check the brain to actually see if it had rabies,,,,,,why not just test the saliva,,,???,,why,,,??,,because rabies is just another fraud,,,,
HANGTHEOWL 1 hour agoI'd never put those two things together. You're right. Why not test the saliva since it was the alleged vector of transmission? That really does not make sense.
duck_fur 2 hours agoMany years ago,,I read an old study from some university they did back in the early 40's,,maybe even 30's,,,where they took the heads of dogs that had died from natural causes,,and sent them in to be tested for rabies,,,,they came back positive,,,,it seems what they test for in the brain as a marker for rabies,,,is also found in healthy brains,,,,,,it is just another one of the fraud Louis Pasteur's scams,,,
WesternCommunity 2 hours agoHehe...that's funny right there. Upvote for you.
Cobb 8 hours agoHeels Up Harris. Pulled herself up by her kneepads, with the ugly looks like a polished turd Willie Brown, Speaker of the Calffornia State Assembly.
Smokey PREMIUM 8 hours agoDay 2 of Biden regime and he's still a huge POS.
Farmerz 6 hours agoGetting huger by the hour
Eric Post 6 hours agoTrump was stupid not to fire this Fauci guy, another Clinton lapdog.
Farmerz 6 hours agoFauci is civil service, it doesn't not come under any president to fire him.
Iron Lady 1 hour agoWe all read the tweets Fauci wrote "fawning" over Clinton here on ZH months ago. At minimum, Trump could have brought out a different face explaining the test cycle standard the CDC was using. Could have been mentioned at the debates. Wasn't.
Trump just didn't do his homework.
Red Corvair 6 hours agoPlease. If Trump had pushed back at all they would have just called him a science denier like they do the rest of us.
Hoss N. Pfeffer 4 hours agoTrump is not part of the establishment, but he was part of the game all along. He never drained that swamp. And look and behold, that swamp is more alive and kicking than ever.
Everybody All American 6 hours agoAnd now after defeating Trump the alligators are emboldened, aggressive, and hungry.
Reaper 6 hours agoDr. Fauci was brought to the fore by none other than Mike Pence I do beilieve.
Voice_of_Doom 6 hours agoEverything the government says is a lie.
LA_Goldbug 6 hours agoJust goes to show you the amazing power the globalist have and how well organized they are.
scytalerules 6 hours agoThey own the Media and the Politicians !!!!
George Bayou 6 hours ago"globalists" "chicoms" lol
convid21 7 hours agoThey still can't prove effectiveness of masks but continue to swear by them.
Pair Of Dimes Shift 7 hours agoEven with a CT of 30, your still going to get 50% false positives
At 15 you'd get some Negatives but not many false Positives.
This test should not be used it's not accurate, not reliable and not fit for purpose.
It's doesn't have any science in it all.
The Governments are only using this to invoke fear in the Public by finding False Positives.
In their view it's better to find more than less, and more leads to lockdowns which demands a VAXX.
Which means the VAXX is a result of Fraud.
LA_Goldbug 6 hours agoThe nasal test is QUANTITATIVE not QUALITATIVE.
Completely useless for the application.
Even the antibody test isn't 100% because not everybody produces IgG all of the time when an infection is present.
T.Gracchus 1 hour agoMore about this here,
https://twitter.com/michaelmina_lab/status/1350162790569402368
Obamanism666 2 hours agoCovid 19 is not a disease, or a virus.
It is a political football.
Anyone who believes in it is a paid-for moron, or maybe just a common or garden idiot.
WesternCommunity 1 hour agoStart wearing the mask or 2 masks then go up to Karens and lambast them for only one mask. The mask is also good for hiding your mouth when doing sheep sounds...... drive the Karens crazy.
Made sheep sounds on the subway today, 5 People got really upset.
Could be even better that wearing a MAGA hat to trigger them.
If caught just say "well if I act like a sheep, I might as well sound like one"
Dogspurt 1 hour ago"Biiiddddeennnn!Biiiddddeennnn! Kaahhhhmmmaaallllaaaaa...."
Tigbits 1 hour agoGo lick the live rail, dumbass!
Klaus Smith 6 hours agoYou appear to be the last remaining covidtard troll in the group downvoting everyone. Soon, you will be out of a job trolling on here. 🤣🤣🤪🤪
Space-Time Continuum 7 hours ago (Edited)Creepy Joe just inaugurated and Covid disappears. YES! That's the hero we need! Hail Biden!
Pro_sanity 1 hour agoAll thanks to the most popular president of all times, as we've seen all those million people there at the inauguration cheering for him.
Shirley Yugest 6 hours agoIt still sucks to be vindicated. Plus it was so obvious. Anyone who didn't see through this from very early on is a total nit wit who shouldn't be allowed to even drive a car.
9-Month Cycle 7 hours agoThere is no covid-19 pandemic. There is only covid-19 panic. The reason for this is the "DEM" in panDEMic is now in the WH.
Pair Of Dimes Shift 7 hours agoWe knew that last year. The inventor himself let everybody know what was up with AIDS testing in Africa years ago. Run it over and over and over and everybody is positive.
Come on, man!! David Icke.... Alex Jones..... do you not gather information online? Only watch the boob tube?
Welcome to what some of us knew 6 months ago, normie sheep!
Jan 19, 2021 | www.unz.com
Jan 11, 2021 | www.zerohedge.com
Authored by John Hunt, M.D. via InternationalMan.com,
In the setting of COVID-19, almost every country in the world closed its borders, locked down its citizens, and forced businesses to close. Today, most governments still restrict travel, economic activity, and social gatherings.
The justification for these unprecedented measures has been a growing number of COVID-19 cases. This has unleashed an epidemic of COVID testing - with PCR and rapid antigen tests as the means of identifying positive COVID cases. Our very own Dr. John Hunt examines the science behind COVID testing, whether the testing paradigms are effective, and the rationality behind government response to the virus.
What COVID tests mean and don't meanRT-PCR tests can be designed to be highly sensitive to the presence of the original viral RNA in a clinical sample. But a highly sensitive test risks poor specificity for actual infectious disease.
Rapid antigen tests are different. They measure viral protein. They do so by reacting a clinical sample with one or two lab-created antibodies that are labeled with a measurable marker. These antigen tests are often poorly specific, meaning they can show as positive in the absence of any actual viral protein or any COVID disease.
For a lab test, what does it mean to be sensitive ? What does it mean to be specific ?I'll use COVID to help explain these terms. In order to do this correctly, we need to avoid using the language of the media and government because those institutions tend to mislead us via language manipulation. For example, they've wrongly taught us that a COVID-positive test is synonymous with COVID- disease. It isn't, as you will soon see.
So for this article, I will use the term "Relevant Infectious COVID Disease" to mean a condition, caused by COVID-19, in which a patient is sickened by the virus or has (in their airways) living replicating virus capable of being transmitted to others. This seems a fair definition of what we should be caring about in this disease. If the patient isn't sick and isn't capable of transmitting the disease, then any COVID RNA or protein that may appear in a test is not relevant, nor infectious, and therefore of little to no consequence.
You can think of a test's sensitivity like this: In a group of 100 people who absolutely have Relevant Infectious COVID Disease, how many people does the test actually report as "positive?" For a test that is 95% sensitive, 95 of these 100 patients with the true disease will be reported by the test as COVID positive and 5 will be missed.
Specificity : In a group of 100 people who absolutely do not have Relevant Infectious COVID Disease, how many will be reported by the test as "negative?" For a test that is 95% specific, 95 of these healthy people will be reported as COVID-negative and 5 will be incorrectly reported as COVID-positive
Sensitivity and Specificity are inherent characteristics of a test, not of a patient, not of a disease, and not of a population. These terms are very different than Positive Predictive Value (PPV) and Negative Predictive Value (NPV). PPV and NPV are affected not only by the test's sensitivity and specificity but also by the characteristics of the people chosen to be tested and, particularly, the patients' underlying likelihood of actually having true Relevant Infectious COVID Disease. The Positive Predictive Value -- the chance a positive test actually indicates a true disease -- is greatly improved if you test people who are likely to have COVID, and, importantly, avoid testing people unlikely to have COVID.
If you do a COVID test with 95% sensitivity and 95% specificity in 1,000 patients who are feverish, have snot pouring out of their noses, are coughing profusely, and are short of breath, then you are using that test as a diagnostic test in people who currently have a reasonable up-front chance of having Relevant Infectious COVID Disease. Let's say 500 of them do actually have Relevant Infectious COVID Disease, and the others have a common cold. This 95% sensitive test will correctly identify 475 of these people who are truly ill with COVID as being COVID-positive, and it will miss 25 of them. This same test is also 95% specific, which means it will falsely label 25 of the 500 non-COVID patients as COVID-positive. Although the test isn't perfect it has a Positive Predictive Value of 95% in this group of people, and is a pretty good test overall .
But what if you run this very same COVID test on everyone in the population? Let's guesstimate that the up-front chance of having Relevant Infectious COVID in the US at this moment is about 0.5% (suggesting that 5 out of 1000 people currently have the actual transmittable disease right now, which is a high estimate). How does this same 95% sensitive/95% specific test work in this screening setting? The good news is that this test will likely identify the 5 people out of every 1000 with Relevant Infectious COVID! Yay! The bad news is that, out of every 1000 people, it will also falsely label 50 people as COVID-positive who don't have Relevant Infectious COVID. Out of 55 people with positive tests in each group of 1000 people, 5 actually have the disease. 50 of the tests are false positives. With a Positive Predictive Value of only 9%, one could say that's a pretty lousy test. It's far lousier if you test only people with no symptoms (such as screening a school, jobsite, or college), in whom the up-front likelihood of having Relevant Infectious COVID Disease is substantially lower.
The very same test that is pretty good when testing people who are actually ill or at risk is lousy when screening people who aren't.
In the first scenario (with symptoms), the test is being used correctly for diagnosis. In the second scenario (no symptoms), the test is being used wrongly for screening .
A diagnostic test is used to diagnose a patient the doctor thinks has a reasonable chance of having the disease (having symptoms like fever, cough, a snotty nose, and shortness of breath during a viral season).
A screening test is used to check for the presence of a disease in a person without symptoms and no heightened risk of having the disease.
A screening test may be appropriate to use when it has very high specificity (99% or more), when the prevalence of the disease in the population is pretty high, and when there is something we can do about the disease if we identify it. However, if the prevalence of a disease is low (as is the case for Relevant Infectious COVID) and the test isn't adequately specific (as is the case with PCR and rapid antigen tests for the COVID virus), then using such a test as a screening measure in healthy people is forcing the test to be lousy. The more it is used wrongly, the more misinformation ensues.
Our health authorities are recommending more testing of asymptomatic people. In other words, they are encouraging the wrong and lousy application of these tests. Our health officials are doing what a first-year medical student should know better than to do. It's enough of a concerning error that it leaves two likely conclusions:
1) that our leading government health officials are truly incompetent and/or
2) that we, as a nation, are being intentionally gaslighted/manipulated. Or it could be both.
(Another conclusion you should consider is that my analysis of these tests is incorrect. I'm open to a challenge.)
So what if you, as an individual, get a positive PCR test result (one that has 95% specificity) without having symptoms of COVID-19 or recent exposure to a true Relevant Infectious COVID Disease patient? What do you do? Well, with that positive test, your risk of having COVID has just increased from less than 5 in 1,000 (the general population risk) to about somewhere perhaps 5 in 55 (the risk of actual Relevant Infectious COVID Disease in asymptomatic people with a COVID-19-positive test). That's an 18-fold increase in risk, amounting to a 9% risk of you having Relevant Infectious COVID Disease (or a 91% chance of you being totally healthy). That may be a relevant increase in risk in your mind, enough that you choose to avoid exposing your friends and family to your higher risk compared to the general population. But if the government spends resources to contact-trace you, then they are contact-tracing 91% of people uselessly. And they are deciding whether to lock us down based on the wrong notion that COVID-positive tests in healthy people are epidemiologically accurate when indeed they are mostly wrong.
For the 50 asymptomatic low-risk people falsely popping positive out of each group of 1,000, what makes them pop positive? For a rapid antigen test, it is because the test is never meant for use as a screening test in healthy asymptomatic people because it's not specific enough. For a PCR test, positivity confidently means that there was COVID RNA in that sample, sure, but your nose or mouth very likely just filtered some dead bits of viral debris from the dust particles in the air as you walked through CVS to get the test before you learned you were supposed to use the drive-through. PCR can be way too sensitive.
A few strands of RNA are irrelevant. Even a few hundred fully intact viral particles are not likely to infect or cause disease. Humans aren't that wimpy. But keep in mind that there is a very small chance that the test popped positive because you are about to get sick with COVID-19, and the test caught you, by pure luck, just before you are to become sick.
On top of this wrong use of diagnostic tests as screening tests, the government has been subsidizing hospitals for taking care of COVID-19-positive patients. Let's say a hospital performs a COVID test 4 times during a hospital stay as a screening test in a patient who has no symptoms of COVID. If that test pops positive once and negative three times, the hospital will report that patient as having COVID-19, even though the one positive result is highly likely to have been a false positive. Why do hospitals do this testing so much? In part, because they'll get $14,000 more from the government for each patient they declare has COVID-19.
When we see statistics of COVID-19 deaths, we should recognize that some substantial percentage of them should be called "Deaths with a COVID-19-positive test." When we see reports of case numbers rising, we should know that they are defining "case" as anyone with a COVID-19-positive test, which, as you might now realize, is really a garbage number.
Summary:
We have an epidemic of COVID-positive tests that is substantially larger than the epidemic of identified Relevant Infectious COVID Disease. In contrast, people with actual, mild cases of COVID-disease aren't all getting tested. So the data, on which lockdowns are supposedly justified, are lousy.
The data on COVID hospitalizations and deaths in the US are exaggerated by a government subsidization scheme that incentivizes the improper use of tests in people without particular risk of the disease.
Avoid getting tested for COVID unless you are symptomatic yourself, have had exposure to someone who was both symptomatic and tested positive for COVID, or have some other personal reason that makes sense.
Know that getting tested before traveling abroad puts you at a modest risk of getting a false-positive test result, which will assuredly screw up your trip. It's a new political risk of travel.
There is a lot more to this viral testing game, and there are a lot of weird incentives. There are gray areas and room for debate.
Yes, the COVID disease can kill people. But a positive test won't kill anybody. Sadly, every COVID-positive test empowers those politicians and bureaucrats who have a natural bent to control people -- the sociopaths and their ilk.
* * *
John Hunt, MD is a pediatric pulmonologist/allergist/immunologist, a former tenured Associate Professor and academic medical researcher, who has extensive experience and publications involving PCR, antigen testing, and analysis of respiratory fluid. He is internationally recognized as an expert in aerosol/respiratory droplet collection and analysis. He's also Doug Casey's coauthor for the High Ground novels Speculator, Drug Lord, and the just-released Assassin , and he is a founding member of the LLC that owns International Man.
* * *
Unfortunately, most people have no idea what really happens when a government goes out of control, let alone how to prepare How will you protect yourself in the event of an economic crisis? New York Times best-selling author Doug Casey and his team just released a guide that will show you exactly how. Click here to download the PDF now .
Jan 09, 2021 | off-guardian.org
Cal , Jan 8, 2021 6:52 PM
Mike Ellwood (Oxon UK) , Jan 9, 2021 1:09 AM Reply to George Mc
I presume that people who get the vaccine(s) will then start testing positive with the PCR test, if they are tested soon afterwards, or even some time afterwards. And so they should, really, since, in a sense, they have been "infected" with some version of the so-called virus. At least that's more or less how vaccination is supposed to work, isn't it?
If that does start happening, I will be fascinated (in a blackly comic way) to see the official reaction. I think it's all going to go very pear shaped (even more than it is now), in ways we probably can't begin to imagine yet.
Dec 25, 2020 | www.moonofalabama.org
H.Schmatz , Dec 24 2020 18:35 utc | 17
The origins of the RT-PCR on which it is based our whole strategy against the Covid-19 pandemic, how it was created and in a rush published in a scientific private review, without obliged previous peer review, and which the conflict of interests are and how some people are profiting from this pandemic:
Turning science into a botch for profit and at the expense of the health of the whole world
Merry Christmas! Take care of your and yours!
Dec 21, 2020 | off-guardian.org
The problem is that CT ( number of amplifications) is an arbitrary and is not reported. See https://www.gene-quantification.de/real-time-pcr-handbook-life-technologies-update-flr.pdf
WHO (finally) admits PCR tests create false positives Warnings concerning high CT value of tests are months too late so why are they appearing now? The potential explanation is shockingly cynical. Kit KnightlyThe World Health Organization released a guidance memo on December 14th, warning that high cycle thresholds on PCR tests will result in false positives .
While this information is accurate, it has also been available for months, so we must ask: why are they reporting it now? Is it to make it appear the vaccine works?
The "gold standard" Sars-Cov-2 tests are based on polymerase chain reaction (PCR). PCR works by taking nucleotides – tiny fragments of DNA or RNA – and replicating them until they become something large enough to identify. The replication is done in cycles, with each cycle doubling the amount of genetic material. The number of cycles it takes to produce something identifiable is known as the "cycle threshold" or "CT value". The higher the CT value, the less likely you are to be detecting anything significant.
This new WHO memo states that using a high CT value to test for the presence of Sars-Cov-2 will result in false-positive results.
To quote their own words [our emphasis]:
Users of RT-PCR reagents should read the IFU carefully to determine if manual adjustment of the PCR positivity threshold is necessary to account for any background noise which may lead to a specimen with a high cycle threshold (Ct) value result being interpreted as a positive result.
They go on to explain [again, our emphasis]:
The design principle of RT-PCR means that for patients with high levels of circulating virus (viral load), relatively few cycles will be needed to detect virus and so the Ct value will be low. Conversely, when specimens return a high Ct value, it means that many cycles were required to detect virus. In some circumstances, the distinction between background noise and actual presence of the target virus is difficult to ascertain.
Of course, none of this is news to anyone who has been paying attention. That PCR tests were easily manipulated and potentially highly inaccurate has been one of the oft-repeated battle cries of those of us opposing the "pandemic" narrative, and the policies it's being used to sell.
Many articles have been written about it, by many experts in the field, medical journalists and other researchers . It's been commonly available knowledge, for months now, that any test using a CT value over 35 is potentially meaningless.
Dr Kary Mullis, who won the Nobel Prize for inventing the PCR process, was clear that it wasn't meant as a diagnostic tool , saying:
with PCR, if you do it well, you can find almost anything in anybody."
And, commenting on cycle thresholds, once said:
If you have to go more than 40 cycles to amplify a single-copy gene, there is something seriously wrong with your PCR."
The MIQE guidelines for PCR use state:
Cq values higher than 40 are suspect because of the implied low efficiency and generally should not be reported,"
This has all been public knowledge since the beginning of the lockdown. The Australian government's own website admitted the tests were flawed, and a court in Portugal ruled they were not fit for purpose .
Even Dr Anthony Fauci has publicly admitted that a cycle threshold over 35 is going to be detecting "dead nucleotides", not a living virus.
Despite all this, it is known that many labs around the world have been using PCR tests with CT values over 35, even into the low 40s.
So why has the WHO finally decided to say this is wrong? What reason could they have for finally choosing to recognise this simple reality?
The answer to that is potentially shockingly cynical: We have a vaccine now. We don't need false positives anymore.
Notionally, the system has produced its miracle cure. So, after everyone has been vaccinated, all the PCR tests being done will be done "under the new WHO guidelines" , and running only 25-30 cycles instead of 35+.
Lo and behold, the number of "positive cases" will plummet, and we'll have confirmation that our miracle vaccine works.
After months of flooding the data pool with false positives, miscounting deaths "by accident" , adding "Covid19 related death" to every other death certificate they can stop. The create-a-pandemic machine can be turned down to zero again.
as long as we all do as we're told. Any signs of dissent – masses of people refusing the vaccine, for example – and the CT value can start to climb again, and they bring back their magical disease .
Hugo , Dec 21, 2020 4:14 AM
In an interview, Dr. Wodarg said he had checked his own blood oxygen saturation with a simple test on his finger after wearing a mask for several minutes. It had dropped from 98 to 94 percent. It is different when climbers hike in regions with low oxygen levels; the organism gets used to this and reacts by producing red blood cells. 50 percent of the oxygen we take in is consumed by our brain alone.
That is why the consequences for children wearing a mask are so devastating: their brains are still growing. The constant inhalation of their own carbon dioxide makes them sleepy, lame, unfocused and listless. In addition, the mask creates a hotbed of moisture in which germs thrive. If, on the other hand, we snort into the crook of our arms, they dry out. Open windows prolong life. Especially for smokers, whose organism is pre-damaged, for example, by a lifelong lack of oxygen.
TFS , Dec 20, 2020 11:09 AM
Former Brexit Party letter to the Secretary of State for Health:
Testing for Coronavirus and Government lockdown policies
https://www.thebrexitparty.org/letter-to-secretary-of-state-for-health/JudyJ , Dec 20, 2020 1:02 PM Reply to TFS
Excellent letter, reply requested by 22 December. A long list of questions to be answered but, if the Government truly has a grip on what they are doing and can demonstrate that they have the supporting evidence, the questions should not be difficult to answer. When I was a civil servant in a London HQ many years ago now, we regularly received requests like this, often with 24 hours notice to reply, and we would have to drop everything else to deal with them. All the receiving Minister's office do is send the request to the appropriate policy unit where responsibility for drafting answers could be shared between any number of staff – one member of staff might deal with, say, three simple questions or one more complex question. But meeting the deadline should not be a problem if one assumes the information is readily accessible as we would be led to believe. We shall see.
Quote from letter: "We trust that this letter will be taken seriously"
In my best pantomime voice 'Oh no it won't.'
aspnaz , Dec 20, 2020 2:33 AM
Read chapter 11 "What happened to the scientific method" of Kary Mullis's (inventor of the PCR test) "Dancing in the mind field" ( https://b-ok.cc/book/1523791/8aa4c2 ) to get his take on why these people are so corrupt.
In summary, he describes what I would call the "Science Industrial Complex" which is basically useless people leaching money from the government teat by creating "imminent disasters" that scare the population, and hence motivate the politicians, into handing out research grants for the most ridiculous projects without any real scientific proof, such as climate change.
Here is an extract:
Imagine two hypothetical labs competing for public funds.
One of those labs announces in a series of scientific papers that they have found some unexpected and very interesting phenomena in the upper atmosphere that contradict the currently accepted theories on the radiogenic formation of carbon-14. This could have a dramatic impact on the radioisotopic dating of fossils. The time frame for human evolution might be a tenth of what has previously been concluded. We may have evolved from the fossils in the Oldavai Gorge in only a couple of hundred thousand years. All of biology may be much younger than we think. More research would be required to confirm this. Biologists all over the world are curious and very excited. The lab is requesting a million dollars from the National Science Foundation to conduct a more detailed study.
A second lab working on upper atmospheric physics calls a press conference to report preliminary data on what appears to be a giant hole in the ozone layer and warns the reporters that if something isn't done about it -- including millions of dollars in grants to study it further -- the world as we know it will be coming to a tragic end. Skin cancer is epidemic, and there are reports of sheep going blind from looking up to the sky. People are starting to worry about having sunglasses that shield their eyes from ultraviolet light. Children begin to learn about it in school, and they are taught to notice the intensity of the UV light when they get off the bus.
Which one of these two laboratories will get funding? Follow the money trail from your pocket to the laboratories and notice that it passes through politicians who need you and by the interest groups who with the media train you.from "Dancing in the mind field" by Kary Mullis, inventor of the PCR test.
-CO , Dec 20, 2020 7:27 PM Reply to aspnaz
There are different sciences that use different methods. The so-called "scientific method" itself is based on speculative philosophical principles that cannot be proven in or by science since they specify the very conditions required for the scientific knowledge process to exist and to operate.
aspnaz , Dec 20, 2020 10:44 PM Reply to -CO
Mirriam-Webster defines it as: "principles and procedures for the systematic pursuit of knowledge involving the recognition and formulation of a problem, the collection of data through observation and experiment, and the formulation and testing of hypotheses".
Can you illustrate your point with some examples of scientific methods that differ from the above?
I think that Mullis is pointing out where the above scientific method, however you may want to describe it but involving the fundementals of proof of a hypothesis using empirical evidence, has been overtaken by commercial interests in a way that uses the credibility of the scientific method to sell untested hypotheses that provide some financial gain to the sponsor.
Dec 13, 2020 | www.moonofalabama.org
Down South , Dec 13 2020 21:06 utc | 36
So let me point out the key part for you:
the paper that established the Drosten PCR test for the Wuhan strain of coronavirus that has subsequently been adopted with indecent haste by the Merkel government along with WHO for worldwide use–resulting in severe lockdowns globally and an economic and social catastrophe–was never peer-reviewed before its publication by Eurosurveillance journal. The critics point out that, "the Corman-Drosten paper was submitted to Eurosurveillance on January 21st 2020 and accepted for publication on January 22nd 2020. On January 23rd 2020 the paper was online."Incredibly, the Drosten test protocol, which he had already sent to WHO in Geneva on 17 January, was officially recommended by WHO as the worldwide test to determine presence of Wuhan coronavirus, even before the paper had been published.
As the critical authors point out, for a subject so complex and important to world health and security, a serious 24-hour "peer review" from at least two experts in the field is not possible.
How is it possible that a credible scientific study in the means to test for COVID-19 is completed, peer-reviewed and accepted as the general standard in less than a couple of weeks after China announces the emergence of a new virus ?????
uncle tungsten , Dec 13 2020 21:41 utc | 43
Hausmeister , Dec 13 2020 23:03 utc | 50Down South #36
How is it possible that a credible scientific study in the means to test for COVID-19 is completed, peer-reviewed and accepted as the general standard in less than a couple of weeks after China announces the emergence of a new virus ?????Thank you for every word in your post. +++ The frenetic scramble to demonstrate the infallibility of private financed science over public funded and cautious institutions seems to be the driver here. As soon as I grasped the Bill Gates link with the WHO it was clear that neo liberal economics had engulfed the world leading health institution.
You simply cannot believe their blather as it is entirely at the service of neo liberal economics and therefore propaganda first, second, and third with a veneer of science fact somewhere.
Meanwhile USA passenger flights arrive in Sydney. No doubt 'PCR screened'
Hausmeister , Dec 13 2020 23:54 utc | 59Down South | Dec 13 2020 21:06 utc | 36 and @vk 30
I applaud you, Down South, and I cannot see the qualification vk has for his claims. I would not sign each sentence of the Engdahl paper but as a gross evaluation it is correct.
If you get a PCR test done in Germany you cannot be sure that the ORF-1-gen, that is specific for CoV-2, has been tested too. So this test may mistake with Corona-something. You cannot learn the applied number of cycles which is of essential importance for the interpretation of this test.
The test was not seriously validated. There was no need to speed up with this paper at Eurosvurveillance, justified only for selling the test. Drosten is co-editor of Eurosurveillance. Undeclared conflicts of interest are, in my opinion, reason enough to reject this paper.
And, @vk, I have no idea about your motivation to spread this propaganda. In Germany there is now very heavy censorship also in social media. What you cite is the standard excuse those lovers of censorship sell here.William Gruff , Dec 13 2020 23:57 utc | 60vk | Dec 13 2020 23:17 utc | 53
Sorry, that is nonsense. The Drosten paper has not been peer-reviewed. That first. How deep the scientific flaws in it are neither you or I can assess. And the hair-rising conflicts of interest were never communicated.
As sad canuck | Dec 13 2020 22:45 utc | 48 showed with a brilliant example these PCR-tests (their essential details are not known to you or me) can be easily used to artificially, adjust" the number that you need as a legitimatization for your politics. Yes, there are without doubt that many dead people. But again: in this politicized environment neither you nor I know what the reason of their death was.
...Even if we assume that half of the PCR covid results are false positives, what would that establish? Wouldn't that just demonstrate that the fatality rate is twice as high? And isn't diagnosis still done by a doctor anyway? The tests are just screening.
Basically, what is with the hyperventilating about false positives? What am I missing here?
Dec 13, 2020 | www.moonofalabama.org
vk , Dec 13 2020 18:45 utc | 19
Down South , Dec 13 2020 19:51 utc | 257) China is doing PCRs since the dawn of time and there is not an explosion of new cases as the anti-PCR squad is claiming. On the contrary: when they decided to re-test all the Wuhan inhabitants with obligatory PCR tests, they found none, zero, nada positive results.
Blue Dotterel , Dec 13 2020 19:00 utc | 22
Posted by: Down South | Dec 13 2020 17:55 utc | 16
Posted by: vk | Dec 13 2020 18:45 utc | 19As I understand it, the false positives are a result of poorly conducting the analyses through putting the samples through too many cycles. If you intensify the concentration of the virus more than 25 cycles, you are likely to get false positives. This apparently has been a problem in the US and other EU countries.
Any country that conducts the test properly significantly reduces the probability of false positives.
Most likely China, among others, does it properly
js , Dec 13 2020 22:28 utc | 47Blue Dotterel @ 22
Exactly so.
None of them are arguing that COVID-19 does not exist, it is that the maximum reasonably reliable Ct value is 30 cycles.and as you increase the cycles above that you start getting more false positive results as only non-infectious (dead) viruses are detected.
The issue that the report raised is that the WHO and Drosden are recommending a Ct of 45 . The higher the cycles the more the "cases" the more drastic the action the government will take to bring the number of "cases" down.
Therefore, to ensure that the government action is reasonable it is necessary to ensure that the information the government is using to justify such action is indeed reasonable and justifiable.
You have to be an absolute idiot to think that government diktats should simply be obeyed and not questioned especially by people who have the necessary credentials to evaluate such information.
sad canuck , Dec 13 2020 22:45 utc | 48Well, it is sad to note absolute lack of intellectual curiosity about something that most likely will not pass without profoundly changing western societies. On side note it would be good to recognise both taoist and christian way of handling the exception of sickness – being sick of sickness is way less dangerous than people being religiously afraid of contamination, of sick people, and organising accordingly.
Most likely this, now already mental, curse will not pass before one or all of the following happens:
– forced vaccination using either public or private coercion or both,
– global (or regional) digital health IDs and tracking systems,
– social, health and education sectors of lesser states will be overridden and forced open to global international providers,
– not to mention that the precendent of tiers and lockdowns is established and can be used repeatedly for the purpose of global health imperialism. There'll be the mandate to force people self-isolate as well.One could say these are the markings of global sanitary dictature. Or, this could be the way to make formal the hidden features of the system currently in use. The spooky license will be made official. All the tracking, etc.
The Drosten testing non-protocol is faulty to the core, and – without doubt – it is enabling corruption of both politics and science (cormandrostenreview.com).
Resulting actions are criminal in their essence – that is the reason why we are seeing leaders of nations acting in such a bizarre way. The truth is being established by the means of spectacle. Once harsh and overdecisive, then lacking in resoluteness – even in the EU the countries still can not coordinate simple and relevant statistics.
China has nothing to gain from this virus, hence there it is mostly over and done with. Seems to go for Russia as well.
Still, they are playing the ball. Wonder why?
vk @ 40 said "of course the scientific standards for times of emergency do fall because of time constraints. That doesn't mean the debunk attempts aren't equally flawed".
I'm sorry but this is not the way science works and cutting corners during emergencies is an even worse practice. The amplification issue, lack of Standard Operational Protocol, and clear bias and hijacking of the peer review process for this paper which formed the foundation of PCR implementation is utterly and completely outrageous. But of course not surprising. It's clear that all UN agencies including WHO have been corrupted. Right from the beginning there has been a consistent and widespread effort to discredit any testing method aside from PCR. Are you not even remotely interested why?
It's easy to see how COVID testing with a flawed PCR testing procedure rolls out and I will give you an example from a place that I am familiar with. COVID has magically disappeared in Thailand, but large number of positive cases are appearing in Thai who are returning and in foreign visitors. These PCR positives are occurring in spite of all returnees having tested negative just prior to boarding their flight to Thailand. Almost all of the positives in returning residents are also of the asymptomatic variety. I would wager that the amplification level for a domestic PCR test is 25 while the returning resident test level is set at 35 or higher. Lacking transparency and a Standard Operational Protocol for the RT-PCR test, including a universally accepted amplification level, you can create any result you want, any time, any place. These are serious issues and you can't label people who have issues with scientific integrity as deniers or misleading.
The entire justification of PCR as a public health tool (as opposed to a diagnostic tool) has been vaporized and I cannot for the life of me understand why you don't "get it" or the wider implications.
Dec 10, 2020 | www.zerohedge.com
DrBrown 8 hours ago (Edited)
Hillary's Fish Taco 6 hours ago remove linkCycle threshold is everything with the PCR test. Anything above 35 is rubbish. 97% false positives. Chris Martenson just presented some compelling information regarding these tests. A recent paper basically shoots down a paper ( Corman-Drosten paper ) that was rushed to press (before any real peer review) in January 2020 that declared the PCR test the end all best way to test for covid. NOT TRUE. It was never meant for this purpose and is now being grossly abused by TPTB. The paper says:
3. The number of amplification cycles (less than 35; preferably 25-30 cycles); In case of virus detection, >35 cycles only detects signals which do not correlate with infectious virus as determined by isolation in cell culture [reviewed in 2]; if someone is tested by PCR as positive when a threshold of 35 cycles or higher is used (as is the case in most laboratories in Europe & the US), the probability that said person is actually infected is less than 3%, the probability that said result is a false positive is 97% [reviewed in 3]
Most testing sites are using a cycle threshold of 40 or more meaning the results mean nothing. In fact many labs are using a CT of 47! The paper goes on to say:
3. The number of amplification cycles It should be noted that there is no mention anywhere in the Corman-Drosten paper of a test being positive or negative, or indeed what defines a positive or negative result. These types of virological diagnostic tests must be based on a SOP, including a validated and fixed number of PCR cycles (Ct value) after which a sample is deemed positive or negative. The maximum reasonably reliable Ct value is 30 cycles. Above a Ct of 35 cycles, rapidly increasing numbers of false positives must be expected . PCR data evaluated as positive after a Ct value of 35 cycles are completely unreliable. Review Report by an International Consortium of Scientists in Life Sciences (ICSLS) - Corman-Drosten et al., Eurosurveillance 2020 (Updated: 29.11.2020) Citing Jaafar et al. 2020 [3]: "At Ct = 35, the value we used to report a positive result for PCR, <3% of cultures are positive." In other words, there was no successful virus isolation of SARS-CoV-2 at those high Ct values. Further, scientific studies show that only non-infectious (dead) viruses are detected with Ct values of 35 [22]. Between 30 and 35 there is a grey area, where a positive test cannot be established with certainty. This area should be excluded. Of course, one could perform 45 PCR cycles, as recommended in the Corman-Drosten WHO-protocol (Figure 4), but then you also have to define a reasonable Ct-value (which should not exceed 30). But an analytical result with a Ct value of 45 is scientifically and diagnostically absolutely meaningless (a reasonable Ct-value should not exceed 30). All this should be communicated very clearly. It is a significant mistake that the Corman-Drosten paper does not mention the maximum Ct value at which a sample can be unambiguously considered as a positive or a negative test-result. This important cycle threshold limit is also not specified in any follow-up submissions to date.
The PCR test will go down in history as the biggest part of this scamdemic. Covid 19 was a novel virus resulting in a bad flu that killed the elderly and the already ill.
That will be Covid's legacy...the politicians will be shamed for all eternity.
Dec 06, 2020 | www.zerohedge.com
For The First Time, A US State Will Require Disclosure Of PCR 'Cycle Threshold' Data In COVID Tests by Tyler Durden Sun, 12/06/2020 - 10:45 Twitter Facebook Reddit Email Print
We have detailed the controversy surrounding America's COVID "casedemic" and the misleading results of the PCR test and its amplification procedure in great detail over the past few months.
As a reminder, "cycle thresholds" (Ct) are the level at which widely used polymerase chain reaction (PCR) test can detect a sample of the COVID-19 virus. The higher the number of cycles, the lower the amount of viral load in the sample; the lower the cycles, the more prevalent the virus was in the original sample.
Numerous epidemiological experts have argued that cycle thresholds are an important metric by which patients, the public, and policymakers can make more informed decisions about how infectious and/or sick an individual with a positive COVID-19 test might be. However, as JustTheNews reports, health departments across the country are failing to collect that data .
Here are a few headlines from those experts and scientific studies:
2. The Wadworth Center, a New York State laboratory, analyzed the results of its July tests at the request of the NYT: 794 positive tests with a Ct of 40: " With a Ct threshold of 35 , approximately half of these PCR tests would no longer be considered positive ," said the NYT. "And about 70% would no longer be considered positive with a Ct of 30! "
3. An appeals court in Portugal has ruled that the PCR process is not a reliable test for Sars-Cov-2 , and therefore any enforced quarantine based on those test results is unlawful.
4. A new study from the Infectious Diseases Society of America , found that at 25 cycles of amplification, 70% of PCR test "positives" are not "cases" since the virus cannot be cultured, it's dead. And by 35: 97% of the positives are non-clinical.
5. PCR is not testing for disease, it's testing for a specific RNA pattern and this is the key pivot. When you crank it up to 25, 70% of the positive results are not really "positives" in any clinical sense , since it cannot make you or anyone else sick
So, in summary, with regard to our current "casedemic", positive tests as they are counted today do not indicate a "case" of anything. They indicate that viral RNA was found in a nasal swab. It may be enough to make you sick, but according to the New York Times and their experts, probably won't. And certainly not sufficient replication of the virus to make anyone else sick. But you will be sent home for ten days anyway, even if you never have a sniffle. And this is the number the media breathlessly reports... and is used to fearmonger mask mandates and lockdowns nationwide...
https://platform.twitter.com/embed/index.html?dnt=false&embedId=twitter-widget-0&frame=false&hideCard=false&hideThread=false&id=1335459652004286466&lang=en&origin=https%3A%2F%2Fwww.zerohedge.com%2Fmedical%2Ffirst-time-us-state-will-require-disclosure-pcr-test-cycle-data&partner=tweetdeck&siteScreenName=zerohedge&theme=light&widgetsVersion=ed20a2b%3A1601588405575&width=550px
All of which is background for an intriguing decision made by Florida's Department of Health (and signed off on by Florida's Republican Governor Ron deSantis).
For the first time in the history of the pandemic, a state will require that all labs in the state report the critical "cycle threshold" level of every COVID-19 test they perform .
All positive, negative and indeterminate COVID-19 laboratory results must be reported to FDOH via electronic laboratory reporting or by fax immediately. This includes all COVID-19 test types - polymerase chain reaction (PCR), other RNA, antigen and antibody results.
Cycle threshold (CT) values and their reference ranges , as applicable, must be reported by laboratories to FDOH via electronic laboratory reporting or by fax immediately.
Full press release below:
3 hours agoTry this on for size, pulled it from the comments at Naturalnews.com :
I have a PhD in virology and immunology. I'm a clinical lab scientist and have tested 1500 "supposed" positive Covid 19 samples collected here in S. California. When my lab team and I did the testing through Koch's postulates and observation under a SEM (scanning electron microscope), we found NO Covid in any of the 1500 samples.
What we found was that all of the 1500 samples were mostly Influenza A and some were influenza B, but not a single case of Covid, and we did not use the B.S. PCR test.
We then sent the remainder of the samples to Stanford, Cornell, and a few of the University of California labs and they found the same results as we did, NO COVID. They found influenza A and B.
All of us then spoke to the CDC and asked for viable samples of COVID, which CDC said they could not provide as they did not have any samples. We have now come to the firm conclusion through all our research and lab work, that the COVID 19 was imaginary and fictitious. The flu was called Covid and most of the 225,000 dead were dead through co-morbidities such as heart disease, cancer, diabetes, emphysema etc. and they then got the flu which further weakened their immune system and they died. I have yet to find a single viable sample of Covid 19 to work with. We at the 7 universities that did the lab tests on these 1500 samples are now suing the CDC for Covid 19 fraud. the CDC has yet to send us a single viable, isolated and purifed sample of Covid 19.
If they can't or won't send us a viable sample, I say there is no Covid 19, it is fictitious. The four research papers that do describe the genomic extracts of the Covid 19 virus never were successful in isolating and purifying the samples. All the four papers written on Covid 19 only describe small bits of RNA which were only 37 to 40 base pairs long which is NOT A VIRUS. A viral genome is typically 30,000 to 40,000 base pairs. With as bad as Covid is supposed to be all over the place, how come no one in any lab world wide has ever isolated and purified this virus in its entirety? That's because they've never really found the virus, all they've ever found was small pieces of RNA which were never identified as the virus anyway. So what we're dealing with is just another flu strain like every year... play_arrow 30 play_arrow
Gunston_Nutbush_Hall 3 hours ago (Edited)
Sardonicus 3 hours agoTks my point exactly in general, setting aside any Trump innuendo but keeping straight up "scientific method(s)"
And if I were to continue my post it would be similar based upon what you have written hereto:
Sorry Rick DeSantis, the question I would have been really impressed by you asking is not the back end falsifiable PCR testing but the front end question I have been asking for 12 months!: please provide me from five different independent laboratories, via independent gold standard, an empirically isolated, separated, purified, and replicated as sole direct external biological causation agent, for one or all "COVID19" symptoms to any human being, as "contagious/pathogenic" "virus."
I would nominate Rick DeSantis for the Nobel Prize on that experiment! ;-)
sparkadore 2 hours agoNo one is testing for, or counting, financial deaths.
There are way more of those.
Bastiat 2 hours agoThe brainwashing is very real. The MSM simply report the daily memo sent to them by the spin Doctors in the alphabet agencies. Social media and search engine algorithms have been adjusted to assist you in RightThink.
That leaves the comment section in zh as the voice in the wilderness.
God help us all.
Decimus Lunius Luvenalis 3 hours agoHeard from a friend the other day: an elderly health compromised couple both got ill and went to the doctor to get tested for flu. The doctor tested them for COVID and, surprise, they both came back "positive." No test for flu. So, 2 new "COVID cases" and perhaps another "COVID" death. Meanwhile flu deaths have dropped off the chart for the season.
idontcare 2 hours ago (Edited)And this is how the imbecile Biden and his ilk will claim 'victory' over the vid. They chose 'cases' as the benchmark so they'll simply change how a 'case' is defined all the while hiding behind the 'science' while never citing the 'science' or explaining why their cherry picked 'science' is valid.
How interesting that 'science' has now been transformed by those that desire to 'rule' into religious mystery. It must be believed, never questioned, you are guilty of something and therefore must self-regulate, but they'll provide absolution.
Patrick Bateman Jr. 1 hour agoTruth if you consider that only 6% of the 277K+ deaths have been categorized as CV19 deaths without co-morbidities according to the CDC's own data. My # just uses the total # of "reported deaths" ("w/ CV" not necessarily "from CV") accdg to the CDC.
ThePub'Lick_Hare 2 hours agoI just divided 260,000 by 350 million. My math might be off. But that 99.999 stretches out even farther into the 9's if we take out the Covid deaths with co-morbidities and use the 6%.
We are destroying an entire way of life and allowing the media, state, and others to dictate our behavior in our homes over a stronger variant of the flu that has virtually no chance of killing us. You can go mad thinking about it too much
Ajax_USB_Port_Repair_Service_ 3 hours ago (Edited)Time for every state to follow Florida by class action suit. This farce has gone on too long. Kudos to Florida for taking the initiative. Now at last people can ask relevant questions and insist on proper protocol. The Portuguese High Court saw false COVID testing for what it is, the spark and flame of a reign of terror. Time to douse the flames and the douche-bags inflaming the scam-demic.
daveO 3 hours agoLowering the test magnification nation wide would be a brilliant covid rescue plan for whoever wins the presidency.
Ajax_USB_Port_Repair_Service_ 2 hours ago (Edited)Whoever wins the presidency is not running this SCAMDEMIC. But, yes, they will do it by spring.
deFLorable hillbilly 2 hours ago (Edited)" Whoever wins the presidency " Will get the credit.
Agree, covid hysteria is being controlled by some group more powerful than our president.
LiberateUS 2 hours ago (Edited)Ron DeSantis is the best governor, by far, in any of the 57 states.
He is fearless and pro-American.
PS- I forgot about Noem in SD. It’s a tie. That chick rocks red, white and blue too.
bustdriver 2 hours ago#3 .Desantis is extremely knowledgeable about the pcr test, extremely intelligent, and a person of integrity. C 19 is just another annual flu that affects only already sick or very elderly people. He knows that, and using CT of 25 or lower will reveal only people who have a virus load that will cause symptoms and illness. Those are the people that need medical attention. Everyone has small virus particles in their bloodstream, which are harmless. Vaccines inject viruses into your bloodstream.
fackbankz 2 hours ago"Approximately 150,000 people die every day, worldwide. That’s 52 million people that have died so far this year. Cardiovascular diseases (CVDs) are the number 1 cause of death globally, taking an estimated 17.9 million lives each year. Close to 800,000 people die due to suicide every year, which is one person every 40 seconds.
Coronavirus has killed 1.5 million people worldwide so far this year.
Perhaps this can offer a little perspective"I bet you'll see a marked decrease in deaths from CVDs in 2020 because a lot of them are being blamed on Covid-1984.
Dec 06, 2020 | www.zerohedge.com
The lockdowns are based on surging "cases" which are based on positive PCR test results.
However, what exactly is a positive PCR test result? What does it mean? As Dr. Tommy Megremis summarized recently :
If you are generally aware, the PCR test is used to amplify small amount of genetic material so as to recognize patterns of DNA by "cycling." (Also, for RNA virus, the RNA is converted to DNA in order to be detected, it's just the way the test works) This is how we have been able to recognize the genomes in Egyptian mummies and Wooly Mammoths. It works because if you amplify and cycle enough times to "grow" legitimate DNA fragments, you get something with with a fair amount of specificity. W hat is becoming more and more apparent is that the PCR test was not designed as a diagnostic tool for infection, and really cannot function as one without having a huge amount of false positives, period.
When it comes to COVID, the presence of viral particles picked up by the PCR technique does not and has not been quantitatively linked to an active "symptomatic" infection. It simply cannot be so, because infection threshold as a result of viral load is different for each patient. It turns out, if you "cycle" over around 25 times, the false positivity of COVID infection starts getting very high.
I and others have explained in blogs how people can be exposed to virus, and mount a simple innate immune response and never know any differently. When you test these people with very low viral loads, who are not sick, you can find the viral RNA code that is used to "diagnose" if you cycle enough times. The last I read, Labcorp cycles at least 40 times to detect viral genome fragments. The PCR test was never intended for diagnosis of infection but as a qualitative test for presence of parts of a virus genome. I know there has been some confusion circulating the net about what the inventor Kary Mullis had said about that. But we walk daily with people who have any number of parts of killer virus or bacterial genomes which one could pick up with a PCR test if one had the specific test for it. Would we claim that that individual was an infected patient? No!
So given all that, PeakProsperity's Chris Martenson explains below , in great details, the answer to the most important question you should ask if you or a loved one gets a positive PCR test result .
"What's the Cycle Threshold (CT) value for that test?"
Sounds wonky but it's actually really important to understand. A low CT value means someone is loaded with virus. A high value, oppositely, means less of a viral load.
Beyond a certain level the load is insufficient to either infect someone else or be of any clinical or epidemiological relevance whatsoever.
The problem? Governments all over the country and world are basing their decisions on CT values that are very high. Too high.
https://www.youtube.com/embed/eWqNl4UUlH0
https://lockerdome.com/lad/13084989113709670?pubid=ld-dfp-ad-13084989113709670-0&pubo=https%3A%2F%2Fwww.zerohedge.com&rid=www.zerohedge.com&width=890
* * *
Links:WHO PCR 47 (!) Cycles
CT over 35 is non-infectious
Cycle Thresholds Too Damn High
https://www.nytimes.com/2020/08/29/health/coronavirus-testing.html
Corman Drosten retraction request
https://cormandrostenreview.com/report/
Bad Testing Video Sept 1
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UK PCR positive standards
Kansas CT cutoff of 42
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6 hours ago remove link
GenuineAmerican 3 hours agoJon Rappoport (excellent blog) nails it in some of his recent posts.
.
"July 16, 2020, podcast, 'This Week in Virology': Tony Fauci makes a point of saying the PCR Covid test is useless and misleading when the test is run at '35 cycles or higher.' A positive result, indicating infection, cannot be accepted or believed.
"Here, in techno-speak, is an excerpt from Fauci's key quote: ' If you get [perform the test at] a cycle threshold of 35 or more the chances of it being replication-competent [aka accurate] are miniscule you almost never can culture virus [detect a true positive result] from a 37 threshold cycle even 36 '
"Too many cycles, and the test will turn up all sorts of irrelevant material that will be wrongly interpreted as relevant.
"That's called a false positive.
"What Fauci failed to say on the video is: the FDA, which authorizes the test for public use, recommends the test should be run up to 40 cycles. Not 35.
"Therefore, all labs in the US that follow the FDA guideline are knowingly or unknowingly participating in fraud. Fraud on a monstrous level, because millions of Americans are being told they are infected with the virus on the basis of a false positive result, and
"The total number of Covid cases in America -- which is based on the test -- is a gross falsity.
"The lockdowns and other restraining measures are based on these fraudulent case numbers.
play_arrowBaNNeD oN THe RuN 7 hours agoFauci has lied again the PCR maximum cycle for a accurate test results is 25 NOT 35. PCR is run, or should be run at 21-25 cycles everything else will give a false positive. Had a friend in Scottsdale MAYO. I had to go to this god-forsaken place to get him out. They were running the PCR at 42 cycles to keep him in the hospital because he had very, very good UNION insurance!! The health industries are all crooks, lying to people to get more money being paid to the orgainizations by the feds.
NatsarimAmericanoLion 6 hours agoIQ tests were always seriously flawed, just like the PCR test
https://medium.com/incerto/iq-is-largely-a-pseudoscientific-swindle-f131c101ba39
It does not measure creative or lateral thinking ability at all.
I had scores that put me in the top 0.5% but I had no illusion that made me anything more than a good test taker.
choctaw charley 5 hours ago remove linkU.S TOTAL DEATHS
2015: 2,602,000
2016: 2,744,248
2017: 2,649,000
2018: 2,839,205
2019: 2,909,000
According to usalivestats(dot)com, there are 2,486,700 so far this year. There could be a lag in reports, but I doubt enough to fulfill their doomsday claims. The CDC still admits only 6% of these "COVID" are without 2 or more comorbidities, so that's about 25,000 or so. This is a mild flu season. Here are the recent flu numbers:
FLU DEATHS 2010's
2010: 36,656
2011: 12,447
2012: 42,570
2013: 37,930
2014: 51,376
2015: 22,705
2016: 38,230
2017: 61,099
2018: 34,157flyonmywall 9 hours agoso what's the purpose behind the bogus plandemic. In order to institute a one world plantation several things have to happen. Foremost is the sense of "nationhood". a nation can be thought of as modeled on the family unit. We look similar, we share religious beliefs, economic and political views and we have a common history which we take pride in. We trust rely on and help another. If you have half a brain you don't need me to describe how all these are under attack. So how does the plandemic play into this? Yesterday you neighbor was your neighbor. Today he is behind a mask because the government tells you that he is a threat to you and your family and you to his! The plandemic was used to to hugely expand the mail-in ballot fraud further driving in the wedge suspicion. Then there is this: when you get your covid test there will be a permanent file created with your name on it. It will contain your genetic code and the test result. this will become the social register that is all over Europe. Get a traffic ticket; late in making a payment; engage in disapproved political activity as I am doing at this moment? All these will find their way into your file and will in the future determine the rate you pay on your home mortgage whether you can be employed in a government job, what you have to endure to board a commercial aircraft etc. There is also a great likelihood that contained in the vaccine will be a tracking component. Consider also population segment most vulnerable to covid: older retired people drawing on an already bankrupt social security ponzi scheme. Hitler referred to these as "Useless Eaters". He had a system in place to rid society of these. Later these faciliries were expanded to include the Jewish population.
Zero-Hegemon 4 hours agoI've done lots of PCR in my life. If you have to do over 35 cycles to detect or amplify something, you're probably barking up the wrong tree or there is something wrong with your assay.
Once you ramp up the cycles to past 35-40 cycles, you're just amplifying non-specific competing amplification products, of which there are always some.
You could have the best designed primers in the world, there is always some random **** that happens to get amplified at high cycle counts.
KimAsa 9 hours ago (Edited)False positives are beneficial for obtaining COVID money and creating hysteria.
Ride_the_kali_yuga 9 hours agothese psychopaths have redesignated the normal course of annual deaths from heart disease, and other common ailments that old people die from, to Covid 19, to create the illusion of a deadly pandemic. they claim to have isolated this virus out of one side of their mouth, out the the other side they claim it has mutated (how many times?) so can't produce proof that this virus even exists. and out of their ******* they claim to have developed a vaccine?
this is and always has been about the vaccinating the public for free moral agency prevention.
africoman 9 hours agoCovid "tests" are an efficient way to feed the false pandemic narrative with nonsensical numbers of "contaminations". Masks are a mark of submission.
Schooey 6 hours agoRe-posting someone's comment from this article Here
- If the masks work -- Why the six feet?
- If the six feet works -- Why the masks?
- If both of the above work -- Why the lockdowns?
- If all three of the above work -- Why the vaccine?
- If the vaccine is safe -- Why protect it with a no liability clause?
- If the vaccine is safe---Why not test it on animals first before using it on humans?
- If SARS-CoV-2 exists -- Why has it never been isolated?
- If SARS-CoV-2 has never been isolated -- How can an effective vaccine be developed?
- If the RT-PCR test works -- Why so many false positives?
- If Kary Mullis, the inventor of the RT-PCR test who conveniently died in August 2019, says his test shouldn't be used to diagnose infectious diseases -- Why use it to detect SARS-CoV-2?
- If there is an epidemic---Why so many empty hospitals?
- If large numbers of people are dying from SARS-CoV-2---Why so many fake causes of death on death certificates?
- If SARS-CoV-2 exists -- Why give doctors financial incentives to diagnose SARS-CoV-2?
- If the official COVID-19 narrative is defensible -- Why censor people who dispute this narrative?
by John Wear, (retired) lawyer, accountant, and author.
Excellent points, now let's threw a monkey wrench in it to the Operation Warp Speed play_arrow
KimAsa 9 hours ago (Edited)Its all BS
Ms No 8 hours agothese psychopaths have redesignated the normal course of annual deaths from heart disease, and other common ailments that old people die from, to Covid 19, to create the illusion of a deadly pandemic. they claim to have isolated this virus out of one side of their mouth, out the the other side they claim it has mutated (how many times?) so can't produce proof that this virus even exists. and out of their ******* they claim to have developed a vaccine?
this is and always has been about the vaccinating the public for free moral agency prevention.
smacker 8 hours agoThey actually murdered people with the lockdown too though. Knowingly and premeditated...certainly some of those were also declared covid.
kellys_eye 9 hours ago" this is and always has been about the vaccinating the public "
Correct.
That has become clear. What we are only now slowing learning is what the sinister motive is.
Harry Tools 5 hours agoIs the test for Covid or Covid-19. Can it tell the difference? The 'normal' flu and influenza are both corona viruses and this is the 'high season' for such cases in the Northern hemisphere.
Strangely (or not) the incidence of actual flu and influenza are suspiciously MUCH lower than they should be.
Ergo - tests that prove 'positive' for Covid are likely either false OR reporting on the flu/influenza.
The LIES keep mounting and mounting.
RedNeckMother 3 hours agothere is no pandemic
MoreFreedom 5 hours ago remove linkI will add another: FDA: 40 recommendation for testing
And let's not forget the comments by Fauci that if they're testing at 35 they're going to get a lot of false positives.
There's an attorney in Ohio who has filed a FOI to obtain all the ct levels used by the labs testing in Ohio. It will be very interesting once that is revealed - I'm sure our governor already knows the answer. If I recall, the NYT itself did an article on this very topic awhile back and estimated that 90% of the positive results in CT and NY were bogus. And going from 40 to 35 I believe reduces positives by 63%.
We're being played.
SRV 7 hours agoDr. Martenson's videos are very good. He's clear.
As for "the science" and scientists, we all make mistakes. If we didn't make mistakes, we wouldn't have scientists pointing out other scientist's mistakes. But it's not a question of whose science is correct, it's that science is no excuse for taking away peoples' liberty.
smacker 9 hours agoThe inventor of the test (Dr Kary Mullis) was very outspoken that it was NOT developed for human virus confirmation...he died of cancer just weeks before the first Covid cases (hmmmm).
The test procedure was developed as a screening tool in lab research, and he won a Nobel Prize for it!It's in your face proof of the scam we're all being subjected to that almost no one ever questioned (brilliant move really)... ONE cycle above 35 (each cycle doubles the amplification) will explode the the false positives.
And... if you have no symptoms you DO NOT have the virus (remember how much play the "asymptomatic" BS story got early on... another psyop). Notice how none of the athletes never get sick and are back in two weeks... yet it's never questioned by a soul paid to look the other way!
smacker 7 hours ago remove link" What is becoming more and more apparent is that the PCR test was not designed
as a diagnostic tool for infection, and really cannot function as one without having
a huge amount of false positives, period. "This is not knew and didn't need to become "more and more apparent".
The inventor of the PCR test Kary Mullis is on video record stating it. Sadly his expert
knowledge has been wilfully ignored by the political elites and countless talking heads
and "experts" because it doesn't suit them and didn't fit their agenda.It's time to prepare the gallows and stock up with rope.
smacker 7 hours ago remove linkThe PCR test is used precisely because it can be manipulated to produce as many "cases" as wanted.
Just turn the dial up on "amplification cycles" and hey presto, you get as many positives as you want.
The cases are not genuine cases but simply PCR positive tests, but are reported as "cases" and then
"infections" by MSM who are "In On It".The idea is "FEAR Management" which allows draconian CovID rules like lockdowns and tiers and
social distancing to be introduced which accustoms people to being managed and controlled.It then ramps up demand for vaccines which is the ultimate objective. Initially (or soon after), the
vaccines will contain nano-technology - dust-chips - which will be used for surveillance and control.
Some say they will also contain ingredients to render people infertile (ie population control).We are seeing in plain sight the biggest coup ever against mankind.
It must be stopped.
The PCR test is used precisely because it can be manipulated to produce as many "cases" as wanted.
Just turn the dial up on "amplification cycles" and hey presto, you get as many positives as you want.
The cases are not genuine cases but simply PCR positive tests, but are reported as "cases" and then
"infections" by MSM who are "In On It".The idea is "FEAR Management" which allows draconian CovID rules like lockdowns and tiers and
social distancing to be introduced which accustoms people to being managed and controlled.It then ramps up demand for vaccines which is the ultimate objective. Initially (or soon after), the
vaccines will contain nano-technology - dust-chips - which will be used for surveillance and control.
Some say they will also contain ingredients to render people infertile (ie population control).We are seeing in plain sight the biggest coup ever against mankind.
It must be stopped.
4 hours ago
Dec 02, 2020 | www.rt.com
By Peter Andrews , Irish science journalist and writer based in London. He has a background in the life sciences, and graduated from the University of Glasgow with a degree in genetics A peer review of the paper on which most Covid testing is based has comprehensively debunked the science behind it, finding major flaws. They conclude it's utterly unsuitable as a means for diagnosis – and the fall-out is immense.
Last week, I reported on a landmark ruling from Portugal, where a court had ruled against a governmental health authority that had illegally confined four people to a hotel this summer. They had done so because one of the people had tested positive for Covid in a polymerase chain reaction (PCR) test – but the court had found the test fundamentally flawed and basically inadmissible.
Now the PCR testing supremacy under which we all now live has received another crushing blow. A peer review from a group of 22 international experts has found 10 "major flaws" in the main protocol for such tests. The report systematically dismantles the original study , called the Corman-Drosten paper, which described a protocol for applying the PCR technique to detecting Covid.
The Corman-Drosten paper was published on January, 23, 2020, just a day after being submitted, which would make any peer review process that took place possibly the shortest in history. What is important about it is that the protocol it describes is used in around 70 percent of Covid kits worldwide. It's cheap, fast – and absolutely useless.
ALSO ON RT.COM Landmark legal ruling finds that Covid tests are not fit for purpose. So what do the MSM do? They ignore it The 10 deadly sinsAmong the fatal flaws that totally invalidate the PCR testing protocol are that the test:
is non-specific, due to erroneous primer design
is enormously variable
cannot discriminate between the whole virus and viral fragments
has no positive or negative controls
has no standard operating procedure
does not seem to have been properly peer reviewed
Oh dear. One wonders whether anything at all was correct in the paper. But wait – it gets worse. As has been noted previously , no threshold for positivity was ever identified. This is why labs have been running 40 cycles, almost guaranteeing a large number of false positives – up to 97 percent, according to some studies.
The cherry on top, though, is that among the authors of the original paper themselves, at least four have severe conflicts of interest. Two of them are members of the editorial board of Eurosurveillance, the sinisterly named journal that published the paper. And at least three of them are on the payroll of the first companies to perform PCR testing!
ALSO ON RT.COM YouTube removes lockdown-sceptical interview with renowned immunologist Dr Mike Yeadon for 'violating terms of service' Heroes we deserveThe 22 members of the consortium that has challenged this shoddy science deserve huge credit. The scientists, from Europe, the USA, and Japan, comprise senior molecular geneticists, biochemists, immunologists, and microbiologists, with many decades of experience between them.
They have issued a demand to Eurosurveillance to retract the Corman-Drosten paper, writing: " Considering the scientific and methodological blemishes presented here, we are confident that the editorial board of Eurosurveillance has no other choice but to retract the publication. '' Talk about putting the pressure on.
It is difficult to overstate the implications of this revelation. Every single thing about the Covid orthodoxy relies on 'case numbers', which are largely the results of the now widespread PCR tests. If their results are essentially meaningless, then everything we are being told – and ordered to do by increasingly dictatorial governments – is likely to be incorrect. For instance, one of the authors of the review is Dr Mike Yeadon, who asserts that, in the UK, there is no 'second wave' and that the pandemic has been over since June. Having seen the PCR tests so unambiguously debunked, it is hard to see any evidence to the contrary.
ALSO ON RT.COM All vaccines, including the new Covid ones, carry a tiny risk of serious side effects. But does that mean we shouldn't take them? The house of cards collapsesWhy was this paper rushed to publication in January, despite clearly not meeting proper standards? Why did none of the checks and balances that are meant to prevent bad science dictating public policy kick into action? And why did it take so long for anyone in the scientific community to challenge its faulty methodology? These questions lead to dark ruminations, which I will save for another day.
Even more pressing is the question of what is going to be done about this now. The people responsible for writing and publishing the paper have to be held accountable. But also, all PCR testing based on the Corman-Drosten protocol should be stopped with immediate effect. All those who are so-called current 'Covid cases', diagnosed based on that protocol, should be told they no longer have to isolate. All present and previous Covid deaths, cases, and 'infection rates' should be subject to a massive retroactive inquiry. And lockdowns, shutdowns, and other restrictions should be urgently reviewed and relaxed.
Because this latest blow to PCR testing raises the probability that we are not enduring a killer virus pandemic, but a false positive pseudo-epidemic. And one on which we are destroying our economies, wrecking people's livelihoods and causing more deaths than Covid-19 will ever claim.
Think your friends would be interested? Share this story!
The statements, views and opinions expressed in this column are solely those of the author and do not necessarily represent those of RT.
Dec 02, 2020 | www.moonofalabama.org
gm , Dec 2 2020 0:16 utc | 187
Good one from Vanessa Beeley:On Sean Penn as possible US deep state tool
Article also touches upon:
-reclusive Israeli billionaire, Vivi Nevo, who sounds from the write-up like a latter day Jeffrey Epstein replacement figure
-use of covid rt-Pcr tests in US under ulterior motives as a HIPPA dodge to mass-collect DNA for Big data/Big tracking and other purposes.
The PCR test, DNA harvesting and false positivesThe validity of the PCR tests in diagnosing Covid-19 has been the subject of much scientific discussion with a growing number of medical experts and analysts dismissing the PCR test as unreliable and inconclusive due to the high percentage of false positives. It is also claimed that this widespread DNA collection under the pretext of Covid-19 could be a covert genetic information harvest on the pretext of extracting viral DNA from all the genetic material.
I spoke with a medical expert who will remain anonymous for security reasons and he informed me that the PCR test is "not designed to diagnose disease." He told me:
"The test identifies a genetic sequence being present in a sample and then copies it, thereby increasing the amount of genetic material. Each test cycle copies and increases the genetic material. A specific amount of GM is required to meet a threshold of detection. The test will keep copying until it is possible to say the virus is "detected". Therein lies the problem. After "Covid" infection, when the virus has been removed by the immune system, some viral genetic debris can remain for many months. A tiny fragment viral, genetic material debris will be found and multiplied by many, many cycles until the detection threshold is reached. This is a false positive."
He informed me that most labs are running upwards of 40 cycles. "In at least 4 examples of RT PCR testing in the US, it was found that 90% of the positive tests were actually false."
He also told me "the real reason they are pushing the testing is control. They want a rapid test to be used every day, multiple times per day to gain entry to school, work, restaurants, entertainment centres etc. It is conditioning."
The sinister question is whether all this genetic DNA information is passed on to undisclosed entities for "research purposes" without the patient's knowledge.
gm , Dec 2 2020 1:37 utc | 188
Clear explanation of meaning of "Ct" (cycle threshhold) in nCoV "+" pcr test [ie What's garbage and what's not]:
Nov 30, 2020 | www.rt.com
By Peter Andrews , Irish science journalist and writer based in London. He has a background in life sciences, and graduated from the University of Glasgow with a degree in genetics. Four German holidaymakers who were illegally quarantined in Portugal after one was judged to be positive for Covid-19 have won their case, in a verdict that condemns the widely-used PCR test as being up to 97-percent unreliable.
Earlier this month, Portuguese judges upheld a decision from a lower court that found the forced quarantine of four holidaymakers to be unlawful. The case centred on the reliability (or lack thereof) of Covid-19 PCR tests.
The verdict , delivered on November 11, followed an appeal against a writ of habeas corpus filed by four Germans against the Azores Regional Health Authority. This body had been appealing a ruling from a lower court which had found in favour of the tourists, who claimed that they were illegally confined to a hotel without their consent. The tourists were ordered to stay in the hotel over the summer after one of them tested positive for coronavirus in a PCR test - the other three were labelled close contacts and therefore made to quarantine as well.
Unreliable, with a strong chance of false positivesThe deliberation of the Lisbon Appeal Court is comprehensive and fascinating. It ruled that the Azores Regional Health Authority had violated both Portuguese and international law by confining the Germans to the hotel. The judges also said that only a doctor can "diagnose" someone with a disease, and were critical of the fact that they were apparently never assessed by one.
READ MORE Immunity for YEARS or DECADES: Covid resistance may last much longer than previously thought, says new researchThey were also scathing about the reliability of the PCR (polymerase chain reaction) test, the most commonly used check for Covid.
The conclusion of their 34-page ruling included the following: "In view of current scientific evidence, this test shows itself to be unable to determine beyond reasonable doubt that such positivity corresponds, in fact, to the infection of a person by the SARS-CoV-2 virus."
In the eyes of this court, then, a positive test does not correspond to a Covid case. The two most important reasons for this, said the judges, are that, "the test's reliability depends on the number of cycles used'' and that "the test's reliability depends on the viral load present.'' In other words, there are simply too many unknowns surrounding PCR testing.
Tested positive? There could be as little as a 3% chance it's correctThis is not the first challenge to the credibility of PCR tests. Many people will be aware that their results have a lot to do with the number of amplifications that are performed, or the 'cycle threshold.' This number in most American and European labs is 35–40 cycles, but experts have claimed that even 35 cycles is far too many, and that a more reasonable protocol would call for 25–30 cycles. (Each cycle exponentially increases the amount of viral DNA in the sample).
Earlier this year, data from three US states – New York, Nevada and Massachusetts – showed that when the amount of the virus found in a person was taken into account, up to 90 percent of people who tested positive could actually have been negative, as they may have been carrying only tiny amounts of the virus.
The Portuguese judges cited a study conducted by "some of the leading European and world specialists," which was published by Oxford Academic at the end of September. It showed that if someone tested positive for Covid at a cycle threshold of 35 or higher, the chances of that person actually being infected is less than three percent, and that "the probability of receiving a false positive is 97% or higher."
While the judges in this case admitted that the cycle threshold used in Portuguese labs was unknown, they took this as further proof that the detention of the tourists was unlawful. The implication was that the results could not be trusted. Because of this uncertainty, they stated that there was "no way this court would ever be able to determine" whether the tourist who tested positive was indeed a carrier of the virus, or whether the others had been exposed to it.
READ MORE I'm an epidemiology professor and I have some genuine concerns about the AstraZeneca Covid vaccine. Here's why Sshhh – don't tell anyoneIt is a sad indictment of our mainstream media that such a landmark ruling, of such obvious and pressing international importance, has been roundly ignored. If one were making (flimsy) excuses for them, one could say that the case escaped the notice of most science editors because it has been published in Portuguese. But there is a full English translation of the appeal, and alternative media managed to pick it up.
And it isn't as if Portugal is some remote, mysterious nation where news is unreliable or whose judges are suspect – this is a western EU country with a large population and a similar legal system to many other parts of Europe. And it is not the only country whose institutions are clashing with received wisdom on Covid. Finland's national health authority has disputed the WHO's recommendation to test as many people as possible for coronavirus, saying it would be a waste of taxpayer's money, while poorer South East Asian countries are holding off on ordering vaccines, citing an improper use of finite resources.
Testing, especially PCR testing, is the basis for the entire house of cards of Covid restrictions that are wreaking havoc worldwide. From testing comes case numbers. From case numbers come the 'R number,' the rate at which a carrier infects others. From the 'dreaded' R number comes the lockdowns and the restrictions, such as England's new and baffling tiered restrictions that come into force next week.
The daily barrage of statistics is familiar to us all by this point, but as time goes on the evidence that something may be deeply amiss with the whole foundation of our reaction to this pandemic – the testing regime – continues to mount
Nov 02, 2020 | www.moonofalabama.org
Vasco da Gama , Nov 1 2020 23:49 utc | 56
Covid-19 is a dangerous disease and I take precautions to protect myself. However, the public depiction of the disease in the media and the actions being taken by most governments cannot but raise some very serious questions.Posted by: Nathan Mulcahy | Nov 1 2020 18:14 utc | 16
THIS! Thank you for all your post Nathan! I was just about contributing some information that ties in precisely with your concern:
COVID-19: Council adopts a recommendation to coordinate measures affecting free movement (13-10-2020)Based on this data, the ECDC should publish a weekly map of EU member states, broken down by regions, to support member states in their decision-making. Areas should be marked in the following colours:
- green if the 14-day notification rate is lower than 25 and the test positivity rate below 4%
- orange if the 14-day notification rate is lower than 50 but the test positivity rate is 4% or higher or, if the 14-day notification rate is between 25 and150 and the test positivity rate is below 4%
- red if the 14-day notification rate is 50 or higher and the test positivity rate is 4% or higher or if the 14-day notification rate is higher than 150
- grey if there is insufficient information or if the testing rate is lower than 300
You will notice how the measures to be taken by individual countries are absolutely (as in 100%) dependent on the worst metric possible according to the demonstrated performance of rtPCR tests. We are being recommended to use the wrong metric! None of us wishes any of our health systems to collapse, however their occupancy objectively varies with the cumulative individual immune response of the population NOT with the precariously measured transmissibility of SARS-CoV-2 via rtPCR tests. Remember that the only reason we are worried about virus transmissibility is because of eventual severe developments of the disease in a fraction of the population and a possible breakdown of health systems as a consequence.
The relevant failure of rtPCR testing is its inability to estimate accurately the viral load (let's not put in question the assumption that viral load is the most important criteria for a severe development of C-19, while also leaving aside aggravating comorbidities). rtPCR testing, under the current state of knowledge, is the equivalent of measuring a patient's temperature with a thermometer but no doctor knows the average body temperature, and its natural healthy interval, nor would the thermometer provide a number on a scale, merely reporting that a patient has something other than "0". This would constitute a USELESS thermometer.
From the same recommendation as above, quote:
Free movement restrictionsMember states should not restrict the free movement of persons travelling to or from green areas. [LOL - great opening, they know full well under these criteria there will be barely any in the next months]
If considering whether to apply restrictions, they should respect the differences in the epidemiological situation between orange and red areas and act in a proportionate manner. They should also take into account the epidemiological situation in their own territory.
Member states should in principle not refuse entry to persons travelling from other member states. Those member states that consider it necessary to introduce restrictions could require persons travelling from non-green areas to:
- undergo quarantine
- undergo a test after arrival
Member states may offer the option of replacing this test with a test carried out before arrival.
Member states could also require persons entering their territory to submit passenger locator forms. A common European passenger locator form should be developed for possible common use.
"Test, test, test" remember? The above simply becomes arbitrary according to the criteria defined. This is not policy based on solid science! Such arbitrary policies usually serve unstated purposes (I'll refrain here to expand on those) while throwing some false pretext to the masses in order to seek their consent, exploiting their limited ability to validate the pretext as legitimate science.
------------------------------------------------------------------------------------
So then... what could be a valid metric that allows us to prevent "eventual severe developments of the disease and a possible breakdown of health systems"? This is the question we should be asking! Myself, I would be satisfied, in substitution of rtPCR testing, with the use of new Hospitalizations, ICU and even Deaths as much better metrics, since these are true fractions of the disease development against any population and even allow to calibrate for its health system performance, much less vulnerable to duplications and false positive accounting.
rtPCR testing is absolutely absurd for the purposes it is being used (ie. country wide government response policy), instead of being limited to clinical diagnostic tool of the individual suspect of some respiratory disease to be used by a qualified practitioner, and, at best, a screening tool to get a handle on local outbreaks (schools, workplaces, residences, etc).
Hanging on this fallacy lies the destruction of most western economies and an ominous verge into the police state, neither are overstatements given what we have seen so far.
Nathan Mulcahy , Nov 1 2020 23:51 utc | 57
Nathan Mulcahy , Nov 2 2020 0:02 utc | 60@ Posted by: Jen | Nov 1 2020 22:08 utc | 43
Thanks for the link, Jen. But it's not that a PCR test cannot detect a SARS-cov2 virus. The problem is that there is no standardized and validated PCR test for detecting SARS-Cov2 virus. I believe in Germany alone there are 200+ variations of the test currently being used.
My concerns about the remaining four points remain.
@ Posted by: Vasco da Gama | Nov 1 2020 23:49 utc | 56
Thanks for adding additional meat to my argument, including the issue with "viral load", which together with the state of the immune system of the host will decide whether or not an infected person will get sick. PCR can be extremely sensitive but that's only part of the picture.
And as I have mentioned in my response to Jen I am yet to find good answers to my remaining the 4 points in my first post (#16)
Oct 21, 2020 | www.globalresearch.ca
Loooks like they reliable detemine only that fact that you do not have infection.
But a positive test can well be a false positive, due to excessive multiplication.
Though the whole world relies on RT-PCR to "diagnose" Sars-Cov-2 infection, the science is clear: they are not fit for purpose By Torsten Engelbrecht and Konstantin Demeter Global Research, October 18, 2020 OffGuardian 27 June 2020 Theme: Intelligence , Science and Medicinehttps://www.facebook.com/plugins/like.php?action=&app_id=&channel=https%3A%2F%2Fstaticxx.facebook.com%2Fx%2Fconnect%2Fxd_arbiter%2F%3Fversion%3D46%23cb%3Dfab1b412cde68%26domain%3Dwww.globalresearch.ca%26origin%3Dhttps%253A%252F%252Fwww.globalresearch.ca%252Ff2afe1228cac1a%26relation%3Dparent.parent&container_width=0&href=https%3A%2F%2Fwww.globalresearch.ca%2Fcovid19-pcr-tests-scientifically-meaningless%2F5717253&layout=button_count&locale=en_US&sdk=joey&send=false&show_faces=false
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First published on June 29, 2020
Lockdowns and hygienic measures around the world are based on numbers of cases and mortality rates created by the so-called SARS-CoV-2 RT-PCR tests used to identify "positive" patients, whereby "positive" is usually equated with "infected."
But looking closely at the facts, the conclusion is that these PCR tests are meaningless as a diagnostic tool to determine an alleged infection by a supposedly new virus called SARS-CoV-2.
Unfounded "Test, Test, Test, " mantra
At the media briefing on COVID-19 on March 16, 2020 , the WHO Director General Dr Tedros Adhanom Ghebreyesus said:
We have a simple message for all countries: test, test, test."
The message was spread through headlines around the world, for instance by Reuters and the BBC .
Still on the 3 of May, the moderator of the Heute j ournal -- one of the most important news magazines on German television -- was passing the mantra of the corona dogma on to his audience with the admonishing words:
Test, test, test -- that is the credo at the moment, and it is the only way to really understand how much the coronavirus is spreading."
This indicates that the belief in the validity of the PCR tests is so strong that it equals a religion that tolerates virtually no contradiction.
But it is well known that religions are about faith and not about scientific facts. And as Walter Lippmann, the two-time Pulitzer Prize winner and perhaps the most influential journalist of the 20th century said: "Where all think alike, no one thinks very much."
So to start, it is very remarkable that Kary Mullis himself, the inventor of the Polymerase Chain Reaction (PCR) technology, did not think alike. His invention got him the Nobel prize in chemistry in 1993.
Unfortunately, Mullis passed away last year at the age of 74, but there is no doubt that the biochemist regarded the PCR as inappropriate to detect a viral infection .
The reason is that the intended use of the PCR was, and still is, to apply it as a manufacturing technique, being able to replicate DNA sequences millions and billions of times, and not as a diagnostic tool to detect viruses.
How declaring virus pandemics based on PCR tests can end in disaster was described by Gina Kolata in her 2007 New York Times article Faith in Quick Test Leads to Epidemic That Wasn't .
Lack of a valid gold standard
Moreover, it is worth mentioning that the PCR tests used to identify so-called COVID-19 patients presumably infected by what is called SARS-CoV-2 do not have a valid gold standard to compare them with.
This is a fundamental point. Tests need to be evaluated to determine their preciseness -- strictly speaking their "sensitivity"[1] and "specificity" -- by comparison with a "gold standard," meaning the most accurate method available.
As an example, for a pregnancy test the gold standard would be the pregnancy itself. But as Australian infectious diseases specialist Sanjaya Senanayake, for example, stated in an ABC TV interview in an answer to the question "How accurate is the [COVID-19] testing?" :
If we had a new test for picking up [the bacterium] golden staph in blood, we've already got blood cultures, that's our gold standard we've been using for decades, and we could match this new test against that. But for COVID-19 we don't have a gold standard test."
Jessica C. Watson from Bristol University confirms this. In her paper "Interpreting a COVID-19 test result" , published recently in The British Medical Journal , she writes that there is a "lack of such a clear-cut 'gold-standard' for COVID-19 testing."
But instead of classifying the tests as unsuitable for SARS-CoV-2 detection and COVID-19 diagnosis, or instead of pointing out that only a virus, proven through isolation and purification, can be a solid gold standard, Watson claims in all seriousness that, "pragmatically" COVID-19 diagnosis itself, remarkably including PCR testing itself, "may be the best available 'gold standard'." But this is not scientifically sound.
Apart from the fact that it is downright absurd to take the PCR test itself as part of the gold standard to evaluate the PCR test, there are no distinctive specific symptoms for COVID-19, as even people such as Thomas Löscher, former head of the Department of Infection and Tropical Medicine at the University of Munich and member of the Federal Association of German Internists, conceded to us[2].
And if there are no distinctive specific symptoms for COVID-19, COVID-19 diagnosis -- contrary to Watson's statement -- cannot be suitable for serving as a valid gold standard.
In addition, "experts" such as Watson overlook the fact that only virus isolation, i.e. an unequivocal virus proof, can be the gold standard.
That is why I asked Watson how COVID-19 diagnosis "may be the best available gold standard," if there are no distinctive specific symptoms for COVID-19, and also whether the virus itself, that is virus isolation, wouldn't be the best available/possible gold standard. But she hasn't answered these questions yet – despite multiple requests. And she has not yet responded to our rapid response post on her article in which we address exactly the same points, either, though she wrote us on June 2nd : "I will try to post a reply later this week when I have a chance."
No proof for the RNA being of viral origin
Now the question is: What is required first for virus isolation/proof? We need to know where the RNA for which the PCR tests are calibrated comes from.
As textbooks (e.g., White/Fenner. Medical Virology, 1986, p. 9) as well as leading virus researchers such as Luc Montagnier or Dominic Dwyer state , particle purification -- i.e. the separation of an object from everything else that is not that object, as for instance Nobel laureate Marie Curie purified 100 mg of radium chloride in 1898 by extracting it from tons of pitchblende -- is an essential pre-requisite for proving the existence of a virus, and thus to prove that the RNA from the particle in question comes from a new virus.
The reason for this is that PCR is extremely sensitive, which means it can detect even the smallest pieces of DNA or RNA -- but it cannot determine where these particles came from . That has to be determined beforehand.
And because the PCR tests are calibrated for gene sequences (in this case RNA sequences because SARS-CoV-2 is believed to be a RNA virus), we have to know that these gene snippets are part of the looked-for virus. And to know that, correct isolation and purification of the presumed virus has to be executed.
Hence, we have asked the science teams of the relevant papers which are referred to in the context of SARS-CoV-2 for proof whether the electron-microscopic shots depicted in their in vitro experiments show purified viruses.
But not a single team could answer that question with "yes" -- and NB., nobody said purification was not a necessary step. We only got answers like "No, we did not obtain an electron micrograph showing the degree of purification" (see below).
We asked several study authors "Do your electron micrographs show the purified virus?", they gave the following responses:
Study 1: Leo L. M. Poon; Malik Peiris. "Emergence of a novel human coronavirus threatening human health" Nature Medicine , March 2020
Replying Author: Malik Peiris
Date: May 12, 2020
Answer: "The image is the virus budding from an infected cell. It is not purified virus."Study 2: Myung-Guk Han et al. "Identification of Coronavirus Isolated from a Patient in Korea with COVID-19", Osong Public Health and Research Perspectives , February 2020
Replying Author: Myung-Guk Han
Date: May 6, 2020
Answer: "We could not estimate the degree of purification because we do not purify and concentrate the virus cultured in cells."Study 3: Wan Beom Park et al. "Virus Isolation from the First Patient with SARS-CoV-2 in Korea", Journal of Korean Medical Science , February 24, 2020
Replying Author: Wan Beom Park
Date: March 19, 2020
Answer: "We did not obtain an electron micrograph showing the degree of purification."Study 4: Na Zhu et al., "A Novel Coronavirus from Patients with Pneumonia in China", 2019, New England Journal of Medicine , February 20, 2020
Replying Author: Wenjie Tan
Date: March 18, 2020
Answer: "[We show] an image of sedimented virus particles, not purified ones."Regarding the mentioned papers it is clear that what is shown in the electron micrographs (EMs) is the end result of the experiment, meaning there is no other result that they could have made EMs from.
That is to say, if the authors of these studies concede that their published EMs do not show purified particles, then they definitely do not possess purified particles claimed to be viral. (In this context, it has to be remarked that some researchers use the term "isolation" in their papers, but the procedures described therein do not represent a proper isolation (purification) process. Consequently, in this context the term "isolation" is misused).
Thus, the authors of four of the principal, early 2020 papers claiming discovery of a new coronavirus concede they had no proof that the origin of the virus genome was viral-like particles or cellular debris, pure or impure, or particles of any kind. In other words, the existence of SARS-CoV-2 RNA is based on faith, not fact.
We have also contacted Dr Charles Calisher, who is a seasoned virologist. In 2001, Science published an "impassioned plea to the younger generation" from several veteran virologists, among them Calisher, saying that:
[modern virus detection methods like] sleek polymerase chain reaction [ ] tell little or nothing about how a virus multiplies, which animals carry it, [or] how it makes people sick. [It is] like trying to say whether somebody has bad breath by looking at his fingerprint."[3]
And that's why we asked Dr Calisher whether he knows one single paper in which SARS-CoV-2 has been isolated and finally really purified. His answer:
I know of no such a publication. I have kept an eye out for one."[4]
This actually means that one cannot conclude that the RNA gene sequences, which the scientists took from the tissue samples prepared in the mentioned in vitro trials and for which the PCR tests are finally being "calibrated," belong to a specific virus -- in this case SARS-CoV-2.
In addition, there is no scientific proof that those RNA sequences are the causative agent of what is called COVID-19.
In order to establish a causal connection, one way or the other, i.e. beyond virus isolation and purification, it would have been absolutely necessary to carry out an experiment that satisfies the four Koch's postulates. But there is no such experiment, as Amory Devereux and Rosemary Frei recently revealed for OffGuardian .
The Tests: The Achilles Heel of the COVID-19 House of CardsThe necessity to fulfill these postulates regarding SARS-CoV-2 is demonstrated not least by the fact that attempts have been made to fulfill them. But even researchers claiming they have done it, in reality, did not succeed.
One example is a study published in Nature on May 7 . This trial, besides other procedures which render the study invalid, did not meet any of the postulates.
For instance, the alleged "infected" laboratory mice did not show any relevant clinical symptoms clearly attributable to pneumonia, which according to the third postulate should actually occur if a dangerous and potentially deadly virus was really at work there. And the slight bristles and weight loss, which were observed temporarily in the animals are negligible, not only because they could have been caused by the procedure itself, but also because the weight went back to normal again.
Also, no animal died except those they killed to perform the autopsies . And let's not forget: These experiments should have been done before developing a test, which is not the case.
Revealingly, none of the leading German representatives of the official theory about SARS-Cov-2/COVID-19 -- the Robert Koch-Institute (RKI), Alexander S. Kekulé (University of Halle), Hartmut Hengel and Ralf Bartenschlager (German Society for Virology), the aforementioned Thomas Löscher, Ulrich Dirnagl (Charité Berlin) or Georg Bornkamm (virologist and professor emeritus at the Helmholtz-Zentrum Munich) -- could answer the following question I have sent them:
If the particles that are claimed to be to be SARS-CoV-2 have not been purified, how do you want to be sure that the RNA gene sequences of these particles belong to a specific new virus?
Particularly, if there are studies showing that substances such as antibiotics that are added to the test tubes in the in vitro experiments carried out for virus detection can "stress" the cell culture in a way that new gene sequences are being formed that were not previously detectable -- an aspect that Nobel laureate Barbara McClintock already drew attention to in her Nobel Lecture back in 1983 .
It should not go unmentioned that we finally got the Charité – the employer of Christian Drosten, Germany's most influential virologist in respect of COVID-19, advisor to the German government and co-developer of the PCR test which was the first to be "accepted" ( not validated! ) by the WHO worldwide – to answer questions on the topic.
But we didn't get answers until June 18, 2020, after months of non-response. In the end, we achieved it only with the help of Berlin lawyer Viviane Fischer.
Regarding our question "Has the Charité convinced itself that appropriate particle purification was carried out?," the Charité concedes that they didn't use purified particles.
And although they claim "virologists at the Charité are sure that they are testing for the virus," in their paper ( Corman et al. ) they state:
RNA was extracted from clinical samples with the MagNA Pure 96 system (Roche, Penzberg, Germany) and from cell culture supernatants with the viral RNA mini kit (QIAGEN, Hilden, Germany),"
Which means they just assumed the RNA was viral .
Incidentally, the Corman et al. paper, published on January 23, 2020 didn't even go through a proper peer review process , nor were the procedures outlined therein accompanied by controls -- although it is only through these two things that scientific work becomes really solid.
Irrational rest results
It is also certain that we cannot know the false positive rate of the PCR tests without widespread testing of people who certainly do not have the virus, proven by a method which is independent of the test (having a solid gold standard).
Therefore, it is hardly surprising that there are several papers illustrating irrational test results.
For example, already in February the health authority in China's Guangdong province reported that people have fully recovered from illness blamed on COVID-19, started to test "negative," and then tested "positive" again .
A month later, a paper published in the Journal of Medical Virology showed that 29 out of 610 patients at a hospital in Wuhan had 3 to 6 test results that flipped between "negative", "positive" and "dubious" .
A third example is a study from Singapore in which tests were carried out almost daily on 18 patients and the majority went from "positive" to "negative" back to "positive" at least once, and up to five times in one patient .
Even Wang Chen, president of the Chinese Academy of Medical Sciences, conceded in February that the PCR tests are "only 30 to 50 per cent accurate" ; while Sin Hang Lee from the Milford Molecular Diagnostics Laboratory sent a l etter to the WHO's coronavirus response team and to Anthony S. Fauci on March 22, 2020, saying that:
It has been widely reported in the social media that the RT-qPCR [Reverse Transcriptase quantitative PCR] test kits used to detect SARSCoV-2 RNA in human specimens are generating many false positive results and are not sensitive enough to detect some real positive cases."
In other words, even if we theoretically assume that these PCR tests can really detect a viral infection, the tests would be practically worthless, and would only cause an unfounded scare among the "positive" people tested.
This becomes also evident considering the positive predictive value (PPV).
The PPV indicates the probability that a person with a positive test result is truly "positive" (ie. has the supposed virus), and it depends on two factors: the prevalence of the virus in the general population and the specificity of the test, that is the percentage of people without disease in whom the test is correctly "negative" (a test with a specificity of 95% incorrectly gives a positive result in 5 out of 100 non-infected people).
With the same specificity, the higher the prevalence, the higher the PPV.
In this context, on June 12 2020, the journal Deutsches Ärzteblatt published an article in which the PPV has been calculated with three different prevalence scenarios .
The results must, of course, be viewed very critically, first because it is not possible to calculate the specificity without a solid gold standard, as outlined, and second because the calculations in the article are based on the specificity determined in the study by Jessica Watson, which is potentially worthless, as also mentioned.
But if you abstract from it, assuming that the underlying specificity of 95% is correct and that we know the prevalence, even the mainstream medical journal Deutsches Ärzteblatt reports that the so-called SARS-CoV-2 RT-PCR tests may have "a shockingly low" PPV.
In one of the three scenarios, figuring with an assumed prevalence of 3%, the PPV was only 30 percent, which means that 70 percent of the people tested "positive" are not "positive" at all . Yet "they are prescribed quarantine," as even the Ärzteblatt notes critically.
In a second scenario of the journal's article, a prevalence of rate of 20 percent is assumed. In this case they generate a PPV of 78 percent, meaning that 22 percent of the "positive" tests are false "positives."
That would mean: If we take the around 9 million people who are currently considered "positive" worldwide -- supposing that the true "positives" really have a viral infection -- we would get almost 2 million false "positives."
All this fits with the fact that the CDC and the FDA, for instance, concede in their files that the so-called "SARS-CoV-2 RT-PCR tests" are not suitable for SARS-CoV-2 diagnosis.
In the "CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel" file from March 30, 2020, for example, it says:
Detection of viral RNA may not indicate the presence of infectious virus or that 2019-nCoV is the causative agent for clinical symptoms"
And:
This test cannot rule out diseases caused by other bacterial or viral pathogens."
And the FDA admits that :
positive results [ ] do not rule out bacterial infection or co-infection with other viruses. The agent detected may not be the definite cause of disease."
Remarkably, in the instruction manuals of PCR tests we can also read that they are not intended as a diagnostic test, as for instance in those by Altona Diagnostics and Creative Diagnostics[ 5 ].
To quote another one, in the product announcement of the LightMix Modular Assays produced by TIB Molbiol -- which were developed using the Corman et al. protocol -- and distributed by Roche we can read:
These assays are not intended for use as an aid in the diagnosis of coronavirus infection"
And:
For research use only. Not for use in diagnostic procedures."
Where is the evidence that the tests can measure the "viral load"?
There is also reason to conclude that the PCR test from Roche and others cannot even detect the targeted genes .
Moreover, in the product descriptions of the RT-qPCR tests for SARS-COV-2 it says they are "qualitative" tests , contrary to the fact that the "q" in "qPCR" stands for "quantitative." And if these tests are not "quantitative" tests, they don't show how many viral particles are in the body .
That is crucial because, in order to even begin talking about actual illness in the real world not only in a laboratory, the patient would need to have millions and millions of viral particles actively replicating in their body.
That is to say, the CDC, the WHO, the FDA or the RKI may assert that the tests can measure the so-called "viral load," i.e. how many viral particles are in the body. "But this has never been proven. That is an enormous scandal," as the journalist Jon Rappoport points out .
This is not only because the term "viral load" is deception. If you put the question "what is viral load?" at a dinner party, people take it to mean viruses circulating in the bloodstream. They're surprised to learn it's actually RNA molecules.
Also, to prove beyond any doubt that the PCR can measure how much a person is "burdened" with a disease-causing virus, the following experiment would have had to be carried out (which has not yet happened):
You take, let's say, a few hundred or even thousand people and remove tissue samples from them. Make sure the people who take the samples do not perform the test.The testers will never know who the patients are and what condition they're in. The testers run their PCR on the tissue samples. In each case, they say which virus they found and how much of it they found. Then, for example, in patients 29, 86, 199, 272, and 293 they found a great deal of what they claim is a virus. Now we un-blind those patients. They should all be sick, because they have so much virus replicating in their bodies. But are they really sick -- or are they fit as a fiddle?
With the help of the aforementioned lawyer Viviane Fischer, I finally got the Charité to also answer the question of whether the test developed by Corman et al. -- the so-called "Drosten PCR test" -- is a quantitative test.
But the Charité was not willing to answer this question "yes". Instead, the Charité wrote:
If real-time RT-PCR is involved, to the knowledge of the Charité in most cases these are [ ] limited to qualitative detection."
Furthermore, the "Drosten PCR test" uses the unspecific E-gene assay as preliminary assay , while the Institut Pasteur uses the same assay as confirmatory assay .
According to Corman et al., the E-gene assay is likely to detect all Asian viruses , while the other assays in both tests are supposed to be more specific for sequences labelled "SARS-CoV-2".
Besides the questionable purpose of having either a preliminary or a confirmatory test that is likely to detect all Asian viruses, at the beginning of April the WHO changed the algorithm, recommending that from then on a test can be regarded as "positive" even if just the E-gene assay (which is likely to detect all Asian viruses! ) gives a "positive" result .
This means that a confirmed unspecific test result is officially sold as specific .
That change of algorithm increased the "case" numbers. Tests using the E-gene assay are produced for example by Roche , TIB Molbiol and R-Biopharm .
High CQ values make the test results even more meaningless
Another essential problem is that many PCR tests have a "cycle quantification" (Cq) value of over 35, and some, including the "Drosten PCR test", even have a Cq of 45.
The Cq value specifies how many cycles of DNA replication are required to detect a real signal from biological samples.
"Cq values higher than 40 are suspect because of the implied low efficiency and generally should not be reported," as it says in the MIQE guidelines .
MIQE stands for "Minimum Information for Publication of Quantitative Real-Time PCR Experiments", a set of guidelines that describe the minimum information necessary for evaluating publications on Real-Time PCR, also called quantitative PCR, or qPCR.
The inventor himself, Kary Mullis, agreed, when he stated :
If you have to go more than 40 cycles to amplify a single-copy gene, there is something seriously wrong with your PCR."
The MIQE guidelines have been developed under the aegis of Stephen A. Bustin , Professor of Molecular Medicine, a world-renowned expert on quantitative PCR and author of the book A-Z of Quantitative PCR which has been called "the bible of qPCR."
In a recent podcast interview Bustin points out that "the use of such arbitrary Cq cut-offs is not ideal, because they may be either too low (eliminating valid results) or too high (increasing false "positive" results)."
https://www.podbean.com/media/player/znrvk-d932a7?from=usersite&vjs=1&skin=1&fonts=Helvetica&auto=0&download=1
And, according to him, a Cq of 20 to 30 should be aimed at, and there is concern regarding the reliability of the results for any Cq over 35.
If the Cq value gets too high, it becomes difficult to distinguish real signal from background, for example due to reactions of primers and fluorescent probes, and hence there is a higher probability of false positives.
Moreover, among other factors that can alter the result, before starting with the actual PCR, in case you are looking for presumed RNA viruses such as SARS-CoV-2, the RNA must be converted to complementary DNA (cDNA) with the enzyme Reverse Transcriptase -- hence the "RT" at the beginning of "PCR" or "qPCR."
But this transformation process is "widely recognized as inefficient and variable," as Jessica Schwaber from the Centre for Commercialization of Regenerative Medicine in Toronto and two research colleagues pointed out in a 2019 paper .
Stephen A. Bustin acknowledges problems with PCR in a comparable way.
For example, he pointed to the problem that in the course of the conversion process (RNA to cDNA) the amount of DNA obtained with the same RNA base material can vary widely, even by a factor of 10 (see above interview).
Considering that the DNA sequences get doubled at every cycle, even a slight variation becomes magnified and can thus alter the result, annihilating the test's reliable informative value.
So how can it be that those who claim the PCR tests are highly meaningful for so-called COVID-19 diagnosis blind out the fundamental inadequacies of these tests -- even if they are confronted with questions regarding their validity?
Certainly, the apologists of the novel coronavirus hypothesis should have dealt with these questions before throwing the tests on the market and putting basically the whole world under lockdown, not least because these are questions that come to mind immediately for anyone with even a spark of scientific understanding.
Thus, the thought inevitably emerges that financial and political interests play a decisive role for this ignorance about scientific obligations. NB, the WHO, for example has financial ties with drug companies, as the British Medical Journal showed in 2010 .
And experts criticize "that the notorious corruption and conflicts of interest at WHO have continued, even grown" since then. The CDC as well, to take another big player, is obviously no better off .
Finally, the reasons and possible motives remain speculative, and many involved surely act in good faith; but the science is clear: The numbers generated by these RT-PCR tests do not in the least justify frightening people who have been tested "positive" and imposing lockdown measures that plunge countless people into poverty and despair or even drive them to suicide.
And a "positive" result may have serious consequences for the patients as well, because then all non-viral factors are excluded from the diagnosis and the patients are treated with highly toxic drugs and invasive intubations. Especially for elderly people and patients with pre-existing conditions such a treatment can be fatal, as we have outlined in the article "Fatal Therapie."
Without doubt eventual excess mortality rates are caused by the therapy and by the lockdown measures, while the "COVID-19" death statistics comprise also patients who died of a variety of diseases, redefined as COVID-19 only because of a "positive" test result whose value could not be more doubtful.
Addendum: We thank Eleni Papadopulos-Eleopulos and Val Turner in particular who made valuable contributions to the realization of this article.
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Torsten Engelbrecht is an award-winning journalist and author from Hamburg, Germany. In 2006 he co-authored Virus-Mania with Dr Klaus Kohnlein, and in 2009 he won the German Alternate Media Award . He has also written for Rubikon, Süddeutsche Zeitung, Financial Times Deutschland and many others.
Konstantin Demeter is a freelance photographer and an independent researcher. Together with the journalist Torsten Engelbrecht he has published articles on the "COVID-19" crisis in the online magazine Rubikon, as well as contributions on the monetary system, geopolitics, and the media in Swiss Italian newspapers.
Oct 06, 2020 | www.rt.com
'False' positive Covid-19 tests saw non-contagious people counted as fresh infections & triggered 2nd wave alarm – Belgian media 5 Oct, 2020 15:36 / Updated 2 hours ago Get short URL FILE PHOTO © Global Look Press / Frank Hoermann / SVEN SIMON 66 Follow RT on Over a half of coronavirus infections revealed this summer by one of Belgium's biggest labs were old and no longer contagious, but were still reported as new cases, local media discovered.
Belgian daily newspaper Het Laatste Nieuws examined the tests carried out by AZ Delta, one of the largest labs in the country, and made a stunning discovery. Almost half of all positive cases reported throughout June, July and August were actually people with an old infection.
The problem, it turns out, lies in the PCR Covid-19 tests. The paper reports that scientific data reveals virus particles can be detected up to 83 days after the actual infection. This led to instances where people were no longer contagious, but were still registered as positive cases. According to HLN, all of these people had to be quarantined.
Belgian experts sounded the alarm in mid-July, when coronavirus numbers spiked after a relief in June, and even insisted that the second wave had already begun for the country.
"We may have had to deal with old infections largely in the summer months," the lab's clinical biologist Frederik Van Hoecke told the paper.
ALSO ON RT.COM Paris to shutter bars for 2 weeks as French capital placed on Covid-19 high alertThe revelation comes as countries look to reintroduce restrictions to curb the spread of the virus.
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Sep 24, 2020 | www.blacklistednews.com
SOURCE: DERRICK BROZE, THE LAST AMERICAN VAGABOND
S EVIDENCE MOUNTS THAT THE "GOLD STANDARD" TEST FOR DETECTING COVID-19 IS UNRELIABLE, WHY ARE HEALTH OFFICIALS AROUND THE WORLD CALLING FOR MORE TESTS?
In the months since the COVID-19 panic began health authorities around the world have told the public to "get tested" to help track the spread of SARS-CoV-2. However, as fear and hysteria subside, the scientific community and public at large are calling into question the efficacy of the test used to determine a patients status. This article is a brief examination of the evidence that the PCR test is unreliable and should not be used as a determinant for the number of COVID-19 cases or as a factor in political decisions.
HOUSTON HEALTH AUTHORITY HAS CONCERNS ABOUT PCR TESTOn August 31, I attended a press conference in Houston to ask the Mayor and Houston Health Authority about reports regarding problems with the Texas Department of State Health Services' numbers on COVID-19 cases. TLAV has previously reported on these concerns with the COVID-19 case numbers in Texas. I also had a chance to ask Houston Health Authority Dr. David Persse about concerns around the test used to detect COVID-19.
The most common test is a polymerase chain reaction (PCR) lab test. This incredibly sensitive technique was developed by Berkeley scientist Kary Mullis, for which he was awarded the Nobel Prize in 1993. The test is designed to detect the presence of a virus by amplifying the virus' genetic material so it can be detected by scientists. The test is viewed as the gold standard, however, it is not without problems.
The PCR test uses chemicals to amplify the virus's genetic material and then each sample goes through a number of cycles until a virus is recovered. This "cycle threshold" has become a key component in the debate around the efficacy of the PCR test.
Dr. Persse says that when the labs report numbers of COVID-19 cases to the City of Houston they only offer a binary option of "yes" for positive or "no" for negative. "But, in reality, it comes in what is called cycle-thresholds. It's an inverse relationship, so the higher the number the less virus there was in the initial sample," Persse explained. "Some labs will report out to 40 cycle-thresholds, and if they get a positive at 40 – which means there is a tiny, tiny, tiny amount of virus there – that gets reported to us as positive and we don't know any different."
Persse noted that the key question is, at what value is someone considered still infectious?
"Because if you test me and I have a tiny amount of virus, does that mean I am contagious? that I am still infectious to someone else? If you are shedding a little bit of virus are you just starting? or are you on the downside?," Dr. Persse asked in the lobby of Houston City Hall. He believes the answer is for the scientific community to set a national standard for cycle-threshold.
Unfortunately, a national standard would not solve the problems expressed by Dr. Persse and others.
UK PARLIAMENT AND SCIENTISTS HAVE CONCERNS ABOUT PCR TESTIn the first weeks of September a number of important revelations regarding the PCR test have come to light. First, new research from the University of Oxford's Center for Evidence-Based Medicine and the University of the West of England found that the PCR test poses the potential for false positives when testing for COVID-19. Professor Carl Heneghan, one of the authors of the study, Viral cultures for COVID-19 infectivity assessment – a systematic review , said there was a risk that an increase in testing in the UK will lead to an increase in the risk of "sample contamination" and thus an increase in COVID-19 cases.
The team reviewed evidence from 25 studies where virus specimens had positive PCR tests. The researchers state that the "genetic photocopying" technique scientists use to magnify the sample of genetic material collected is so sensitive it could be picking up fragments of dead virus from previous infections. The researchers reach a similar conclusion as Dr. David Persse, namely that, "A binary Yes/No approach to the interpretation RT-PCR unvalidated against viral culture will result in false positives with segregation of large numbers of people who are no longer infectious and hence not a threat to public health."
Heneghan, who is also the the editor of BMJ Evidence-Based Medicine, told the BBC that the binary approach is a problem and tests should have a cut-off point so small amounts of virus do not lead to a positive result. This is because of the cycle threshold mentioned by Dr. Persse. A person who is shedding an active virus and someone who has leftover infection could both receive the same positive test result. He also stated that the test could be detecting old virus which would explain the rise in cases in the UK. Heneghan also stated that setting a standard for the cycle threshold would eliminate the quarantining and contact tracing of people who are healthy and help the public better understand the true nature of COVID-19.
The UK's leading health agency, Public Health England, released an update on the testing methods used to detect COVID-19 and appeared to agree with Professor Heneghan regarding the concerns on the cycle threshold. On September 9, PHE released an update which concluded, "all laboratories should determine the threshold for a positive result at the limit of detection."
This is not the first time Heneghan's work has directly impacted the UK's COVID-19 policies. In July, UK health secretary Matt Hancock called for an "urgent review" of the daily COVID-19 death numbers produced by Public Health England after it was revealed the stats included people who died from other causes. The Guardian reported:
"The oddity was revealed in a paper by Yoon K Loke and Carl Heneghan of the Centre for Evidence-Based Medicine at Oxford University, called " Why no one can ever recover from Covid-19 in England – a statistical anomaly ".
Their analysis suggests PHE cross-checks the latest notifications of deaths against a database of positive test results – so that anyone who has ever tested positive is recorded in the COVID-19 death statistics.
A Department of Health and Social Care source said: 'You could have been tested positive in February, have no symptoms, then hit by a bus in July and you'd be recorded as a COVID death.'"
Only days after Hancock called for the review of PHE data, the UK government put an immediate halt to its daily update of death numbers from COVID-19.
On September 8, Heneghan tweeted out another study on the limitations of the PCR test. The study, "SARS-CoV-2 Testing: The Limit of Detection Matters" , examines the limit of detection (LoD) for RNA. The researchers note similar problems with the PCR test and the cycle threshold, concluding, "the ultimate lesson from these studies bears repetition: LoD matters and directly impacts efforts to identify, control, and contain outbreaks during this pandemic."
Heneghan also recently told the BMJ , "one issue in trying to interpret numbers of detected cases is that there is no set definition of a case. At the moment it seems that a polymerase chain reaction (PCR) positive result is the only criterion required for a case to be recognised."
"In any other disease we would have a clearly defined specification that would usually involve signs, symptoms, and a test result," Heneghan explained. "We are moving into a biotech world where the norms of clinical reasoning are going out of the window. A PCR test does not equal covid-19; it should not, but in some definitions it does."
Heneghan says he is concerned that as soon as there is the appearance of an outbreak there is panic and over-reacting. "This is a huge problem because politicians are operating in a non-evidence-based way when it comes to non-drug interventions," he stated.
THE EVIDENCE FOR FALSE POSITIVES IS OVERWHELMINGA recent report from NPR outlines the dangers of false positives with the PCR tests. Andrew Cohen, director of the Center for Research on Aquatic Bioinvasions, was hired by the state of California to study an invasion of non-native mussels. The researchers took water samples and used a PCR test to search for genetic material from the mussels. After the tests came back overwhelmingly positive, Cohen grew suspicious.
"I began to realize that many of these -- if not all of these -- were false positives, especially when they started being reported in waters that had chemistry that would not allow the mussels to reproduce and establish themselves," he told NPR. NPR notes that, depending on the lab, there was a 2 to 8 percent false positive rate.
Once COVID-19 was declared a pandemic, Cohen said he began asking if the reports of people with absolutely no symptoms and positive PCR test results could be false positives. "I began wondering whether these asymptomatic carriers weren't in large part or in whole part the human counterparts of those false-positive results of quagga and zebra mussels in all those water bodies across the West," he said.
Cohen emphasized the importance of researchers taking potential false positive PCR results seriously. "As near as we can tell, the medical establishment and public health authorities and researchers appear to be assuming that the false-positive rate in in the PCR based test is zero, or at least so low that we can ignore it."
Cohen is correct that the scientific authorities need to take false positives seriously, especially when a person can be sent to isolate or quarantine for weeks due to a positive test result. Even the U.S. FDA's own fact sheet on testing acknowledges the dangers posed by false positives:
"The CDC 2019-nCoV Real-Time RT-PCR Diagnostic Panel has been designed to minimize the likelihood of false positive test results. However, in the event of a false positive result, risks to patients could include the following: a recommendation for isolation of the patient, monitoring of household or other close contacts for symptoms, patient isolation that might limit contact with family or friends and may increase contact with other potentially COVID-19 patients, limits in the ability to work, the delayed diagnosis and treatment for the true infection causing the symptoms, unnecessary prescription of a treatment or therapy, or other unintended adverse effects."
A CDC fact sheet also acknowledges the possibility of false positives with the PCR test.
Professor Heneghan believes the confusion around COVID-19 has come as a result of a shift away from "evidence-based medicine." In a recent opinion piece published at The Spectator , Heneghan and Tom Jefferson, a senior associate tutor and honorary research fellow at the Centre for Evidence-Based Medicine, University of Oxford, wrote that patients have become a "prisoner of a system labelling him or her as 'positive' when we are not sure what that label means." The two scientists offer this conclusion and warning:
RELATED ARTICLES: Tuesday, September 8, 2020 - "Dead" Virus Cells Frequently Trigger "False Positives" In Most Common COVID Test, New Study FindsGovernments are producing a series of contradictory and confusing policies which have a brief shelf life as the next crisis emerges. It is increasingly clear the evidence is often ignored. Keeping up to date is a full time occupation, and the advances of the last 30 years have at best been put on hold.
The duties of a good doctor include working in partnership with patients to inform them about what they want or need in a way they can understand, and respecting their rights to reach decisions with you about their treatment and care. Questions need to be asked as to how this will occur if you don't see your doctor, particularly if all you have to do is queue in at a drive in to get your answer.
And ultimately what is a 'good test'? We think it's the test which helps your doctor narrow the uncertainty around the origins and management of your problem.
In the past, our reports raising questions about the accuracy of COVID-19 tests have been met with accusations of 'fearmongering' and spreading 'misinformation'.
Wednesday, June 10, 2020 - REPORT: Over 95% of UK "Covid19" deaths had "pre-existing condition"Over 95% of "COVID Deaths" recorded in England and Wales had potentially serious comorbidities, according to statistics released by NHS England. RELATED ARTICLES: Tuesday, September 8, 2020 - "Dead" Virus Cells Frequently Trigger "False Positives" In Most Common COVID Test, New Study Finds
In the past, our reports raising questions about the accuracy of COVID-19 tests have been met with accusations of 'fearmongering' and spreading 'misinformation'.
Aug 29, 2020 | www.nytimes.com
Updated Sept. 17, 2020
The usual diagnostic tests may simply be too sensitive and too slow to contain the spread of the virus.
Some of the nation's leading public health experts are raising a new concern in the endless debate over coronavirus testing in the United States: The standard tests are diagnosing huge numbers of people who may be carrying relatively insignificant amounts of the virus.
Most of these people are not likely to be contagious, and identifying them may contribute to bottlenecks that prevent those who are contagious from being found in time. But researchers say the solution is not to test less, or to skip testing people without symptoms, as recently suggested by the Centers for Disease Control and Prevention .
Instead, new data underscore the need for more widespread use of rapid tests , even if they are less sensitive.
"The decision not to test asymptomatic people is just really backward," said Dr. Michael Mina, an epidemiologist at the Harvard T.H. Chan School of Public Health, referring to the C.D.C. recommendation.
"In fact, we should be ramping up testing of all different people," he said, "but we have to do it through whole different mechanisms."
In what may be a step in this direction, the Trump administration announced on Thursday that it would purchase 150 million rapid tests.
The most widely used diagnostic test for the new coronavirus, called a PCR test, provides a simple yes-no answer to the question of whether a patient is infected.
But similar PCR tests for other viruses do offer some sense of how contagious an infected patient may be: The results may include a rough estimate of the amount of virus in the patient's body.
"We've been using one type of data for everything, and that is just plus or minus -- that's all," Dr. Mina said. "We're using that for clinical diagnostics, for public health, for policy decision-making."
But yes-no isn't good enough, he added. It's the amount of virus that should dictate the infected patient's next steps. "It's really irresponsible, I think, to forgo the recognition that this is a quantitative issue," Dr. Mina said.
The PCR test amplifies genetic matter from the virus in cycles; the fewer cycles required, the greater the amount of virus, or viral load, in the sample. The greater the viral load, the more likely the patient is to be contagious.
This number of amplification cycles needed to find the virus, called the cycle threshold, is never included in the results sent to doctors and coronavirus patients, although it could tell them how infectious the patients are.
In three sets of testing data that include cycle thresholds, compiled by officials in Massachusetts, New York and Nevada, up to 90 percent of people testing positive carried barely any virus, a review by The Times found.
On Thursday, the United States recorded 45,604 new coronavirus cases, according to a database maintained by The Times. If the rates of contagiousness in Massachusetts and New York were to apply nationwide, then perhaps only 4,500 of those people may actually need to isolate and submit to contact tracing.
One solution would be to adjust the cycle threshold used now to decide that a patient is infected. Most tests set the limit at 40, a few at 37. This means that you are positive for the coronavirus if the test process required up to 40 cycles, or 37, to detect the virus.
Tests with thresholds so high may detect not just live virus but also genetic fragments, leftovers from infection that pose no particular risk -- akin to finding a hair in a room long after a person has left, Dr. Mina said.
Any test with a cycle threshold above 35 is too sensitive, agreed Juliet Morrison, a virologist at the University of California, Riverside. "I'm shocked that people would think that 40 could represent a positive," she said.
A more reasonable cutoff would be 30 to 35, she added. Dr. Mina said he would set the figure at 30, or even less. Those changes would mean the amount of genetic material in a patient's sample would have to be 100-fold to 1,000-fold that of the current standard for the test to return a positive result -- at least, one worth acting on.
The Food and Drug Administration said in an emailed statement that it does not specify the cycle threshold ranges used to determine who is positive, and that " commercial manufacturers and laboratories set their own."
The Centers for Disease Control and Prevention said it is examining the use of cycle threshold measures "for policy decisions." The agency said it would need to collaborate with the F.D.A. and with device manufacturers to ensure the measures "can be used properly and with assurance that we know what they mean."
The C.D.C.'s own calculations suggest that it is extremely difficult to detect any live virus in a sample above a threshold of 33 cycles . Officials at some state labs said the C.D.C. had not asked them to note threshold values or to share them with contact-tracing organizations.
For example, North Carolina's state lab uses the Thermo Fisher coronavirus test, which automatically classifies results based on a cutoff of 37 cycles. A spokeswoman for the lab said testers did not have access to the precise numbers.
This amounts to an enormous missed opportunity to learn more about the disease, some experts said.
"It's just kind of mind-blowing to me that people are not recording the C.T. values from all these tests -- that they're just returning a positive or a negative," said Angela Rasmussen, a virologist at Columbia University in New York.
"It would be useful information to know if somebody's positive, whether they have a high viral load or a low viral load," she added.
Officials at the Wadsworth Center, New York's state lab, have access to C.T. values from tests they have processed, and analyzed their numbers at The Times's request. In July, the lab identified 872 positive tests, based on a threshold of 40 cycles.
With a cutoff of 35, about 43 percent of those tests would no longer qualify as positive. About 63 percent would no longer be judged positive if the cycles were limited to 30.
In Massachusetts, from 85 to 90 percent of people who tested positive in July with a cycle threshold of 40 would have been deemed negative if the threshold were 30 cycles, Dr. Mina said. "I would say that none of those people should be contact-traced, not one," he said.
Other experts informed of these numbers were stunned.
"I'm really shocked that it could be that high -- the proportion of people with high C.T. value results," said Dr. Ashish Jha, director of the Harvard Global Health Institute. "Boy, does it really change the way we need to be thinking about testing."
Dr. Jha said he had thought of the PCR test as a problem because it cannot scale to the volume, frequency or speed of tests needed. "But what I am realizing is that a really substantial part of the problem is that we're not even testing the people who we need to be testing," he said.
The number of people with positive results who aren't infectious is particularly concerning, said Scott Becker, executive director of the Association of Public Health Laboratories. "That worries me a lot, just because it's so high," he said, adding that the organization intended to meet with Dr. Mina to discuss the issue.
The F.D.A. noted that people may have a low viral load when they are newly infected. A test with less sensitivity would miss these infections.
But that problem is easily solved, Dr. Mina said: "Test them again, six hours later or 15 hours later or whatever," he said. A rapid test would find these patients quickly, even if it were less sensitive, because their viral loads would quickly rise.
PCR tests still have a role, he and other experts said. For example, their sensitivity is an asset when identifying newly infected people to enroll in clinical trials of drugs.
But with 20 percent or more of people testing positive for the virus in some parts of the country, Dr. Mina and other researchers are questioning the use of PCR tests as a frontline diagnostic tool.
People infected with the virus are most infectious from a day or two before symptoms appear till about five days after. But at the current testing rates, "you're not going to be doing it frequently enough to have any chance of really capturing somebody in that window," Dr. Mina added.
Highly sensitive PCR tests seemed like the best option for tracking the coronavirus at the start of the pandemic. But for the outbreaks raging now, he said, what's needed are coronavirus tests that are fast, cheap and abundant enough to frequently test everyone who needs it -- even if the tests are less sensitive.
"It might not catch every last one of the transmitting people, but it sure will catch the most transmissible people, including the superspreaders," Dr. Mina said. "That alone would drive epidemics practically to zero."
An earlier version of this article, using information provided by a laboratory spokesman, misstated the number of positive coronavirus tests in July processed by Wadsworth Center, New York's state lab. It was 872 tests, not 794. Based on that error, the article also misstated the number of tests that would no longer qualify as positive with a C.T. value of 35 cycles. It is about 43 percent of the tests, not about half of them. Similarly, the article misstated the number of tests that would no longer qualify as positive if cycles were limited to 30. It is about 63 percent of the tests, not about 70 percent.
Apoorva Mandavilli is a reporter for The Times, focusing on science and global health. She is the 2019 winner of the Victor Cohn Prize for Excellence in Medical Science Reporting. @ apoorva_nyc A version of this article appears in print on Aug. 30, 2020 , Section A, Page 6 of the New York edition with the headline: You're Positive. But Are You Contagious? Tests May Be Too Sensitive, Experts Say . Order Reprints | Today's Paper | Subscribe
Sep 23, 2020 | www.thoughtco.com
By Theresa Phillips Updated October 25, 2019
PCR stands for polymerase chain reaction , a molecular biology technique for amplifying segments of DNA, by generating multiple copies using DNA polymerase enzymes under controlled conditions. As little as a single copy of a DNA segment or gene can be cloned into millions of copies, allowing detection using dyes and other visualization techniques.
Developed in 1983, the process of PCR has made it possible to perform DNA sequencing and identify the order of nucleotides in individual genes. The method uses thermal cycling or the repeated heating and cooling of the reaction for DNA melting and replication. As PCR continues, the "new" DNA is used as a template for replication and a chain reaction ensues, exponentially amplifying the DNA template.
https://d956b974574e4d9df2e942a9641c69dc.safeframe.googlesyndication.com/safeframe/1-0-37/html/container.html
PCR techniques are applied in many areas of biotechnology including protein engineering , cloning, forensics (DNA fingerprinting), paternity testing, the diagnosis of hereditary and/or infectious diseases, and for the analysis of environmental samples.
In forensics, in particular, PCR is especially useful because it amplifies even the smallest amount of DNA evidence. PCR can also be used to analyze DNA that is thousands of years old, and these techniques have been used to identify everything from an 800,000-year-old mammoth to mummies from around the world.
PCR Procedure InitializationThis step is necessary only for DNA polymerases that require hot-start PCR. The reaction is heated to between 94 and 96 °C and held for 1-9 minutes.
DenaturationIf the procedure does not require initialization, denaturation is the first step. The reaction is heated to 94-98 °C for 20-30 seconds. The DNA template's hydrogen bonds are disrupted and single-stranded DNA molecules are created.
AnnealingThe reaction temperature is lower to between 50 and 65 °C and held for 20-40 seconds. The primers anneal to the single-stranded DNA template. The temperature is extremely important during this step. If it's too hot, the primer might not bind. If it's too cold, the primer might bind imperfectly. A good bond is formed when the primer sequence closely matches the template sequence.
Extension/ElongationThe temperature during this step varies depending upon the type of polymerase. The DNA polymerase synthesizes a completely new DNA strand.
Final ElongationThis step is performed at 70-74 °C for 5-15 minutes after the final PCR cycle.
Final HoldThis step is optional. The temperature is kept at 4-15 °C and strops the reaction.
Three Stages of the PCR Procedure Exponential AmplificationDuring every cycle, product (the specific piece of DNA that is being replicated) is doubled.
Leveling-off StageAs the DNA polymerase loses activity and consumes reagents, the reaction slows.
Plateau No more product accumulates.
Sep 05, 2020 | www.zerohedge.com
In the past, our reports raising questions about the accuracy of COVID-19 tests have been met with accusations of 'fearmongering' and spreading 'misinformation'.
But not today.
That's because new research from the University of Oxford's Center for Evidence-Based Medicine and the University of the West of England has found that the swab-based technique used for most COVID-19 testing is at risk of returning "false positives" since copies of the virus's RNA detected by the tests might simply be dead, inactive material from a weeks-old infection. Although patients infected with COVID-19 are typically only infectious for a week or less, tests can be triggered by virus genetic material left over from a weeks-old infection.
The team's research involved analyzing 25 studies on the widely used polymerase chain reaction test. PCR tests use material collected with a swab - the most common type of test around the world, and especially in the US - then utilize a "genetic photocopying" technique that allows scientists to magnify the small sample of genetic material collected, which they can then analyze for signs of viral RNA.
What the researchers here have effectively found is that these PCR tests just aren't sensitive enough to distinguish if the viral material is active and infectious, or dead and inert.
For those who desire a more comprehensive understanding of how these tests work, the chart below can be helpful.
Professor Carl Heneghan, one of the authors of the study, said there was a risk that a surge in testing across the UK was increasing the risk of this sample contamination occurring and it may explain why the number of Covid-19 cases is rising but the number of deaths is static.
"Evidence is mounting that a good proportion of 'new' mild cases and people re-testing positives after quarantine or discharge from hospital are not infectious, but are simply clearing harmless virus particles which their immune system has efficiently dealt with," he told the Spectator.
Professor Heneghan added that international scrutiny might be required to avoid "the dangers of isolating non-infectious people or whole communities." ZKnight 14 minutes ago
Fake science. How about purify the virus first and establish a gold standard for testing first. No, of course not because the CDC has a patent for Covid-19 and nobody is allowed to try find it to see if it exists. play_arrow LogicFusion 27 minutes ago
Everybody is a Covid-19 / Coronavirus expert now!
Read about the failed coin dealer and convicted felon's performance. It's hilarious!
Martin Armstrong becomes Covid-19 Coronavirus Expert overnight play_arrow ducksinarow 59 minutes ago
Covid -19 has been so politicized that I don't believe a word of any publication for or against testing, existence of the Virus, or anything that provokes testing or issues opinions about locking down communities. Just like the riots, Covid news is just plain boring. play_arrow ominous 3 hours ago
Link to spectator.co.uk goes to home page, not this story.
Where is the original story posted? play_arrow play_arrow ominous 3 hours ago (Edited)
Perhaps this
https://www.cebm.net/covid-19/infectious-positive-pcr-test-result-covid-19/ y_arrow 1 Rabbi Blitzstein 38 minutes ago
"Give me control of a nation's money, and I care not who makes the laws" - Mayer Amschel Rothschild. play_arrow play_arrow tangent 4 hours ago remove link
People who recommend a vaccine for an entirely cured virus should lose their license to practice medicine. 99.9% cure rate applying to people who take it before being hospitalized is one of the biggest success stories in the history of medicine for HCQ. Not only that, but there are multiple other likely cures that simply have not been studied well. You'd think people would appreciate the fact that the common cold has been cured, but instead they just whine that big pharma isn't getting those bucko bucks.
I honestly expected a ticker tape parade like in the movies when that first cure study came out. But instead they took a massive **** on the study and on the doctor... ****ty world we live in. ay_arrow Pair Of Dimes Shift 2 hours ago
An exec (55+) at my company is gung ho about the vaccine.
Unfortunately, I just had to give him a "wait and see" response although I know vaccines for coronaviruses are impossible. play_arrow 2 play_arrow ThanksIwillHaveAnother 4 hours ago (Edited)
Viruses are not full cells. They are DNA/RNA wrapped with a protein the clings to a cell then the cell imports the DNA/RNA to start making its proteins. So what is inactive? If that person sneezes on another person depending on immune system status that other person could get a bad infection. y_arrow 4 CrabbyR 3 hours ago
viruses utilizes CELL structures and host DNA to replicate dna or rna according to the viruses genetic code, the protein jacket is the final product to
disguise the virus from detection and to bind on another cell after the compromised cell RUPTURES, there's more to it but if it cannot copy itself effectively it can become nonviable and unable to infect another cell. It replicates DNA inside a host cell, It is not a complete organism and cannot replicate unless it can inject its DNA into a host cell. Antibodies cling to viruses and destroy this ability to bind to a target cell. A non viable virus has a damaged coat or DNA RNA that has to many Dimers (damage or code breaks) Bacteria is more in line with what you think a virus is y_arrow onewayticket2 4 hours ago (Edited) remove link
they lost me when they changed the definition of "death" to include "presumed, untested" cases (while bI@#$% ing at me that we needed to "follow the science")....and even got busted for the laughable motorcycle accident being classified as a covid death and the Labs that were sending in 100% positive results. (until they were caught) play_arrow OutaTime43 4 hours ago remove link
The test detects RNA. Not necessarily viable virus. Also, it will detect RNA presence in an individual who may already have antibodies and may be immune. We are bombarded daily by viruses of which we already have immunity. play_arrow sun tzu 10 hours ago
Shocking news that the South Koreans already discovered and published back in May. Western big pharma driven medicine is garbage 😂😂😂
play_arrow Roger Casement 10 hours agoWTF!!!!
World Bank exporting COVID-19 Testing Kits in 2018??????
https: // wits.worldbank.org/trade/comtrade/en/country/ALL/year/2018/tradeflow/Exports/partner/WLD/nomen/h5/product/300215 play_arrow 7 play_arrow sun tzu 10 hours ago
Interesting play_arrow play_arrow Jack Mehoff 1 more time 9 hours ago
Business as usual play_arrow play_arrow Argon1 7 hours ago
Preparation for agenda 2021 in 2017. play_arrow 1 play_arrow CrabbyR 4 hours ago
WOW.......ties a few strands from other sources together into a real ugly picture play_arrow play_arrow Welsh Bard 10 hours ago
The professor who won the Nobel prize for work in this field, said that the way this test is being operated with over forty cycles, means that any results are entirely meaningless.
In Britain, having spent over £15 billion setting up PCR testing systems and a shaky test and trace apparatus on top of that, it appears that 90% of positive results now appear to be false. This is compounded by the fact that when a hot spot develops, more testing is done to show a rapid increase in more false positive results, meaning further new lockdowns and even more testing to prove yet more false positive results ad infinitum.
Now whether this is by design or ineptitude, people must decide for themselves but the outcome is utter chaos.
For those countries who have not followed the Swedish model especially countries like Australia and New Zealand who have set up complete isolation, now face a future perpetually cut off from the rest of the world.
Okay, new techniques will and are coming along to treat the disease like HCQ when used correctly maybe as a prophylactic and a vaccine that will need to be constantly upgraded like the Flu vaccine, means that the whole world has painted itself into a corner unless drastic revision is now made to the whole sorry mess.
In the meantime, we will now be stuck with digital currency and the introduction of ID Health Cards that will limit people in how they travel where they work and access to a whole heap of things like government services.
Welcome to the new world order! play_arrow 1 KuriousKat 11 hours ago (Edited) remove link
Don't tell the Shameless Aussie gov that after arresting hundreds for simply voicing doubt on need to lockdown entire city...Next time it will be thousands and not a damn thing they can do to stop it..These people are trickling us the truth how worthless the tests are when pretty much everyone knows. play_arrow espirit 12 hours ago remove link
Lessee.
WHO
Imperial College
John Hopkins
CDC
Line all those peeps up against the wall, and the first one to rat gets to live.
I'll provide my own ammo... ay_arrow Sick Monkey 6 hours ago
Not everyone working in these agencies are dishonest but like you and I we have to work and eat.
Most of them are trapped in this mess with bills to pay threatened by NDA.
play_arrow 1 Urban Roman 12 hours agoNot particularly new news. Been talked about since April at least -- it's an RNA virus, it has its own polymerase, and it leaves lots of RNA fragments in its wake.
The Corona family of viruses make 5 or 6 strands with partial copies of their RNA molecule. negative copies are made first, and then copied again into positive copies. Finally the one big RNA is made with the entire genome on it.
So about a dozen RNA molecules are made for each finished virus particle that is produced. And finally, a variety of different primers are used for the PCR tests, some are matched to the small partial RNA copies and others are matched to various features on the large whole-virus RNA. They can give different results for the same sample.
So, someone who registers on a PCR test has probably been exposed to the virus, but the test gives no clue as to whether it is an active infection, or the person is contagious, or they are just coming down with it, or they got over it six months ago. play_arrow 4 play_arrow 1
10 play_arrow gordo 12 hours ago remove link
Sweden, no masks, no lock downs, ALL SCHOOLS OPEN, herd immunity, no second wave.
Still think your masks and lock downs are working muppets?
1 play_arrow The 3rd Dimentia 13 hours agohttps://youtu.be/sjYvitCeMPc SARS-CoV2 and the Rise of Medical Technocracy. Lee Merritt, M.D. play_arrow 3 play_arrow hugin-o-munin 13 hours ago
I'm glad to see that many are starting to counter the official narrative.
We've been asleep for too long and allowed these agendas to fester to the point we're at now where a college dropout software salesman and a former 3rd world communist terrorist (neither of whom have any medical degree) are dictating to the world how everyone needs to get a DNA altering vaccine and a medical ID. It's completely nuts and bonkers yet more or less the entire planet's governments follow in 'lockstep' with ever more draconian laws and regulations incarcerating people in their own homes, making them wear masks causing oxygen deprivation and shutting down the entire world economy.
lay_arrow Warthog777 , 13 hours ago
Cabreado , 13 hours agoArticle is poorly written by someone who does not know medical science. There are no viral "cells" so the headline is a put off right away. The comment about "sensitivity" is misplaced as PCR tests are too sensitive: ergo false positives. I believe "specificity" is the word the author was searching for. If a test lumps true positives with false positives, then it lacks specificity.
Crush the cube , 13 hours ago"accusations of 'fearmongering' and spreading 'misinformation'.
But not today."Well, much of the world has known for months now about the testing lies...
and I'd be remiss to not remind the Tylers that they indeed played a role in the fear mongering along the way; quite intently so.
Digital-Anarchy , 14 hours agohttps://play.google.com/store/books/details/Flavio_Bell_Covid_24?id=SxrxDwAAQBAJ
Busted, published 2018, what a scam.
hugin-o-munin , 13 hours agoAnyone who would use the term "virus cells", has no clue what they're talking about and should be completely disregarded. Viruses are not cells. PCR tests are searching for something your body produces in response to a virus as well. They are not produced specifically for a singular virus either. The entire concept of PCR testing is garbage. This **** was a scam from the get-go.
snblitz , 14 hours agoYes it is evident now that this entire pandemic is false and political. The goal seems to be to vaccinate entire populations and the question people need to ask is - why? what for? Aside from the obvious economic motives there are some more sinister plans that most people will have a hard time accepting but these need to be looked at. Several years ago there were a group of doctors and researchers that died of suspicious suicides who were collaborating and studying vaccines and the link to autism.
The effort was led by Dr.Jeffrey Bradstreet who was researching the natural substance GcMAF and how this could boost the immune system. What he discovered was that many vaccines had a compound/substance called Nagalase in them that is unnatural and has a detrimental effect on the immune system and function of GcMAF (which is produced by our own bodies) and has no business at all being in vaccines. Just before he was able to blow the whistle on this he also died of a suspicious 'suicide' and today most of the clinics and research groups working on GcMAF have been destroyed and ruined. Draw your own conclusions.
snblitz , 14 hours agoDr. Kary Mullis invented the PCR test. He said it was ineffective for this purpose.
Though he was addressing its use in a prior virus hoax unleashed upon the world.
I bet you didn't know this scam has been used before.
That is why I was able to call out the scam right from the start. The second I saw them using the PCR again, I knew it was from the same playbook.
aldousd , 13 hours agoSo many lies.
Viruses are not alive. They have no metabolic functions. They cannot move.
Don't believe me? Get a degree is virology or microbiology or just a read a book on the subject. Or capture a wuhan-virus yourself and watch it under a microscope. It won't move. It won't consume anything. It will just sit there inert.
The problem is that you are being lied to at a scale you cannot imagine.
I know, off to the fema re-education camp for me for spreading false information about the wuhan-virus.
Though I am not the one spreading fear and hysteria.
mstyle , 11 hours agoThere article is confused, but the work of the doctor is not. Viruses use your cells to reproduce. When your immune system targets the virus it actually kills your own cell which has become host to the virus. The virus particles and markers, and the DNA of the virus can be detected in these dead cells, but dead cells cannot serve as a factory for more viruses. So it's effectively a dead virus infected cell. Not a dead virus cell.
So while the transcription of the idea here was done by an idiot, it's not an idiotic idea. The tests cannot tell if the virus came in a living cell that is actively producing more viruses or a dead host cell that has been assassinated by your immune system. That's what they're talking about here.
hugin-o-munin , 11 hours agowhat about the chromosome 8 stuff that has been mentioned lately?
(since you appear to be rather intelligent)
IRC162 , 14 hours agoThanks. Well the chromosome 8 discovery in the PCR test specifications/details is strange and worrying because it makes you wonder why it's part of this at all. Some believe it's to get more false positive results while others believe it is what the mRNA vaccines are intended to target and if that's right then it's really sinister. What exactly is the plan? To make all of us get Downs Syndrome? I don't know but judging by all their other lies and schemes it wouldn't surprise me.
adr , 15 hours agoFuggin progressives and their pandemic political prop. But really this reaction is the same as their reaction to 'racial injustice'. They focus on feelings before the facts are known in order to achieve their end, and then do their best to bury/ignore the facts when they are gathered later.
94% COVID deaths with multiple comorbidities.
10 unarmed blacks killed by police in 2019 (6 were in self-defense).
Antiduck , 14 hours agoWhy didn't you mention that nearly all labs are running 35-40 cycles which guarantees a positive test, simply from noise.
The inventor of the test said if you don't find anything after 15 cycles, it probably isn't there. After 20 cycles the noise starts to be greater than any real information. By 30, the test is mostly noise. More than 35, the test is completely worthless.
Of course I've been saying this for five months, but most people didn't listen. After the NYT article came out, people I know started saying, "How did you know?"
I said, "Because I have critical thinking skills. Why didn't you believe me? Name a time I've steered you wrong."
ZenStick , 12 hours ago333 labs in florida had 100% positivity. (stupid word.)
Identify as Ferengi , 15 hours agoExactly correct.
Nobody will touch this line of reasoning in public or on media.
Bastages.naro , 15 hours agoSee above, Born2Bwired.
The PCR test is not useful for what they are using it for apparently. This has been known since the beginning. Here is quote regarding AIDS:
"Kary Mullis, who won the Nobel Prize in Science for inventing the PCR, is thoroughly convinced that HIV is not the cause of "AIDS". With regard to the viral load tests, which attempt to use PCR for counting viruses, Mullis has stated: "Quantitative PCR is an oxymoron." PCR is intended to identify substances qualitatively, but by its very nature is unsuited for estimating numbers. Although there is a common misimpression that the viral load tests actually count the number of viruses in the blood, these tests cannot detect free, infectious viruses at all; they can only detect proteins that are believed, in some cases wrongly, to be unique to HIV. The tests can detect genetic sequences of viruses, but not viruses themselves.
What PCR does is to select a genetic sequence and then amplify it enormously. It can accomplish the equivalent of finding a needle in a haystack; it can amplify that needle into a haystack. Like an electronically amplified antenna, PCR greatly amplifies the signal, but it also greatly amplifies the noise. Since the amplification is exponential, the slightest error in measurement, the slightest contamination, can result in errors of many orders of magnitude."
NYTimes article last week suggested that only 10% of Covid positive PCR tests are clinically significant and infectious.
Jul 27, 2020 | www.rt.com
The problem of false positives from Covid-19 tests means UK is inflating its numbers – and taking wrong decisions Rob Lyons
Rob Lyons is a UK journalist specialising in science, environmental and health issues. He is the author of ' Panic on a Plate: How Society Developed an Eating Disorder'.
Jul 24, 2020 | www.msn.com
We Find the Best $500 Cars to Field in the 24 Hours of Lemons Race Series Sources: Trump erupted over Esper's flag ban
Study identifies six different "types" of COVID-19
A new study of COVID-19 , based on data from a symptom tracker app, determined that there are six distinct "types" of the disease involving different clusters of symptoms. The discovery could potentially open new possibilities for how doctors can better treat individual patients and predict what level of hospital care they would need.
Researchers from King's College London studied data from approximately 1,600 U.K. and U.S. patients who regularly logged their symptoms in the COVID Symptom Tracker App in March and April.
Typically, doctors will look for key symptoms such as cough, fever and loss of the sense of smell to detect COVID-19. The study, which has not been peer-reviewed, says the six different "types" of COVID-19 can vary by severity and come with their own set of symptoms.
"I think it's very, very interesting," Dr. Bob Lahita, who is not affiliated with the study, told CBSN anchors Vladimir Duthiers and Anne-Marie Green. "Among the patients I see, those who recovered, many of them present different ways: some people with fever and some without fever, and some with nausea and vomiting, some people with diarrhea , etc."
The six clusters of symptoms outlined in the study are:
- Flu-like with no fever: Headache, loss of smell, muscle pains, cough, sore throat, chest pain, no fever.
- Flu-like with fever: Headache, loss of smell, cough, sore throat, hoarseness, fever, loss of appetite.
- Gastrointestinal: Headache, loss of smell, loss of appetite, diarrhea, sore throat, chest pain, no cough.
- Severe level one, fatigue: Headache, loss of smell, cough, fever, hoarseness, chest pain, fatigue.
- Severe level two, confusion: Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain.
- Severe level three, abdominal and respiratory: Headache, loss of smell, loss of appetite, cough, fever, hoarseness, sore throat, chest pain, fatigue, confusion, muscle pain, shortness of breath, diarrhea, abdominal pain.
The first level, "flu-like with no fever," is associated with headaches, loss of smell, muscle pains, cough, sore throat and chest pain. Patients at this level have a 1.5% chance of needing breathing support such as oxygen or a ventilator.
The second type, "flu-like with fever," includes symptoms like loss of appetite, headache, loss of smell, cough, sore throat, hoarseness and fever. Researchers say about 4.4% of patients at this level needed breathing support.
Patients with the third type, simply described as "gastrointestinal," do not have a cough as part of their illness. Instead, they experience headache, diarrhea, loss of smell, loss of appetite, sore throat and chest pain, and about 3.3% needed breathing support.
Lahita referred to the following three clusters of COVID-19 as the "really severe types."
In type four, or "severe level one," patients experience fatigue along with headache, loss of smell, cough, fever, hoarseness and chest pain. Patients at this level needed breathing support at a rate of 8.6%.
Type five, "severe level two," includes the symptoms of type four along with loss of appetite, sore throat and muscle pain, and is mainly distinguished by confusion .
"That means you don't know where you are or where you live, whether you are in or out of the hospital, who your relatives are," Lahita explained. "That is very scary." Almost 10% of patients at that level need breathing support.
The most severe type of COVID-19 is referred to as "severe level three, abdominal and respiratory," and has all the above symptoms along with abdominal pain, shortness of breath and diarrhea. Nearly 20% of these patients need breathing support.
"Those are the severe level threes who wind up on a ventilator, and then it is touch-and-go as to whether they survive the infection entirely," Lahita said.
The U.K. researchers also found that only 16% of patients with type one COVID-19 required hospitalization, compared with nearly half of the patients with type six.
Patients in the severe clusters also tended to be older or with pre-existing conditions and weakened immune systems, compared to those in the first three.
Scientists hope the discovery, once further studied, could help predict what types of care patients with COVID-19 might need, and give doctors the ability to predict which patients would fall into which category.
"I'm very happy that these six types have been identified and can give us an idea of a prognosis going forward for patients who are afflicted with this virus," Lahita said.
Jul 18, 2020 | fort-russ.com
By Dr. Sherri Tenpenny – May 21, 2020 – an osteopathic medical doctor, board-certified in three specialties. She is the founder of Tenpenny Integrative Medical Center, a medical clinic located near Cleveland, Ohio. Her company, Courses4Mastery.com provides online education and training regarding all aspects of vaccines and vaccination.
_____________________________
In 1965, scientists identified the first human coronavirus; it was associated with the common cold. The Coronavirus family, named for their crown-like appearance, currently includes 36 viruses. Within that group, there are 4 common viruses that have been causing infection in humans for more than sixty years. In addition, three pandemic coronaviruses that can infect humans: SARS, MERS, and now, SARS-CoV-2.
As the news of deaths in China, South Korea, Italy, and Iran began to saturate every form of media 24/7, we became familiar with a new term: COVID-19. To be clear, the name of the newly identified coronavirus is SARS-CoV-2, short for Severe Acute Respiratory Syndrome Coronavirus-2. This virus is associated with fever, cough, chest pain, and shortness of breath, the complex of symptoms that form the diagnosis of COVID-19.
The Trump administration declared a public health emergency on January 31, 2020, then on February 2 placed a ban on the entry of most travelers who had recently been in China. On February 4, Alex Azar, the Secretary of Health and Human Services (HHS) issued a declaration of public health emergency and activated the Public Readiness and Emergency Preparedness Act, otherwise known as the PREP Act. This nefarious legislation provides complete protection of manufacturers from liability for all products, technologies, biologics, or any vaccine developed as a medical countermeasure against COVID-19. For those nervously waiting for the vaccine to become available, be sure to understand the PREP Act before rushing to the get in line.
Calls for testing – to see if a person is or isn't infected – began soon after the emergency was declared, but performing those tests was initially slow due to an inadequate number of test kits. As the kits became available, those developed by the CDC had a defect: The reagents reacted to the negative control sample , making the test inaccurate and the kits unusable.
In various countries, thousands of test kits purchased from China were found to be contaminated with the SARS-CoV-2 viruses. No one really knows how that happened, but theories spread like wildfire. Could the test kit infect the person being tested? Or, did it mean the test would return a false-positive result, driving up the numbers of those said to be infected so those in power could implement stronger lockdowns and accelerate the hockey-stick unemployment rates? Neither of those questions has been adequately answered.
Mandatory Testing of what?
Authorities claim that testing is important for public health officials to assess if their mitigation efforts – "shelter in place" and "social distancing" and "wearing a mask" – are making a difference to "flatten the curve." Officials also claim that testing is necessary to know how many persons are infected within a community and to understand the nature of how coronaviruses spread.
Are these reasons sufficient to give up our health freedom and our personal rights, being tested and shamed in public?
Despite the challenges with test kits, testing began. By the end of March 2020, more than 1 million people had been tested across the US. By May 9, the number tested had grown to over 8.7M. Testing methods include a swab of the nasal passages or by inserting a long, uncomfortable swab through the nose to scrape the back of the throat. Specimens have also been obtained bronchoalveolar lavage, from sputum , and from stool specimens.
The call for mandatory testing has been gathering steam and becoming ever more onerous. In Washington state, Governor Inslee has declared:
Individuals that refuse to cooperate with contact tracers and/or refuse testing, those individuals will not be allowed to leave their homes to purchase basic necessities such as groceries and/or prescriptions. Those persons will need to make arrangements through friends, family, or state provided 'family support' personnel .
But what do the results really mean?
Who Should Be Tested
On May 8, 2020, the CDC has listed specific priorities for when testing should be done. As of May 16, more than 11-million samples have been collected and more than 3700 specimens have not yet been evaluated.
High Priority
- Hospitalized patients with symptoms
- Healthcare facility workers, workers in living settings, and first responders with symptoms
- Residents in long-term care facilities or other congregate living settings, including prisons and shelters, with symptoms
Priority
- Persons with symptoms of potential COVID-19 infection, including fever, cough, shortness of breath, chills, muscle pain, new loss of taste or smell, vomiting or diarrhea, and/or sore throat
- Persons without symptoms who are prioritized by health departments or clinicians , for any reason, including but not limited to public health monitoring, sentinel surveillance, or screening of asymptomatic individuals according to state and local plans.
Read that last priority again: That means virtually everyone can be required to get a test.
Is that a violation of your personal rights? And, if you submit to testing, what does a "positive test" actually mean?
Types of Testing: RT-PCR
PCR, short for polymerase chain reaction , is a highly specific laboratory technique. The key to understanding PCR testing is that PCR can identify an individual specific virus within a viral family.
Has COVID-19 Testing Made the Problem Worse? Confusion Regarding "The True Health Impacts"However, a PCR test can only be used to identify DNA viruses; the SARS-CoV2 virus is an RNA virus. Therefore, multiple steps must be taken to "magnify" the amount of genetic material in the specimen. Researchers used a method called RT-PCR, reverse transcription-polymerase chain reaction, to specifically identify the SARS-CoV-2 virus. It's a complicated process. To read more about it, go here and here.
If a nasal or a blood sample contains a tiny snip of RNA from the SARS-CoV-2 virus, RT-PCR can identify it, leading to a high probability that the person has been exposed to the SARS-CoV-2 virus.
However – and this is important – a positive RT-PCR test result does not necessarily indicate a full virus is present. The virus must be fully intact to be transmitted and cause illness.
RT-PCR Testing: The Importance of Timing
Even if a person has had all the symptoms associated with a coronavirus infection or has been closely exposed to persons who have been diagnosed with COVID-19, the probability of a RT-PCR test being positive decreases with the number of days past the onset of symptoms.
According to a study done by Paul Wikramaratna and others:
- For a nasal swab, the percentage chance of a positive test declines from about 94% on day 0 to about 67% by day 10. By day 31, there is only a 2% chance of a positive result.
- For a throat swab , the percentage chance of a positive test declines from about 88% on day 0 to about 47% by day 10. By day 31, there is only a 1% chance of a positive result.
In other words, the longer the time frame between the onset of symptoms and the time a person is tested, the more likely the test will be negative.
Repeat testing of persons who have a negative test may (eventually) confirm the presence of viral RNA, but this is impractical. Additionally, repeated testing of the same person can lead to even more confusing results: The test may go from negative, to positive, then back to negative again as the immune system clears out the coronavirus infection and moves to recovery.
And what makes this testing even more confusing is that the FDA admits that "The detection of viral RNA by RT-PCR does not necessarily equate with an infectious virus."
Let's break that down:
You've had all the symptoms of COVID19, but your RT-PCR test for SARS-CoV-2 is negative.
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- Does that mean you're "good to go" – you can go to work, go to school or you can travel? OR
- Does that mean your influenza-like illness was caused by some other pathogen, possibly one of the four coronaviruses that have been in circulation for 60 years? OR
- Does that mean the result is a false-negative and you still have the infection, but it isn't detectable by current tests? OR
- Does that mean it was a sample was inadequately taken due to the faulty technique by the technician? OR
- Does that mean you have not been exposed, and you are susceptible to contracting the infection, and you need to stay in quarantine?
So, what does a "positive" test actually mean? And that's the problem:
No one knows for sure.
Another Type of Testing: Antibodies
According to the nonprofit Foundation for Innovative New Diagnostics (FIND) , more than 200 serologic blood tests, to test for antibodies, are either now available or in development.
There are two primary types of antibodies that are assessed for nearly any type of infection: IgM and IgG. While several new testing devices are being touted as a home test, they are not the same as a home pregnancy test or a glucometer to you're your blood sugar. The blood spot or saliva specimen can be collected at home, must it must then be sent to a laboratory for analysis. It can take a few days – or longer – to get the results. With so many tests in the pipeline, the ability to test at home will be changing over time.
The first antibody to rise is IgM. It rises quickly after the onset of the infection and is usually a sign of an acute, or current, infection. The IgM levels diminish quickly as the infection resolves. The FDA admits they do not know how long the IgM remains present for SARS-CoV-2 as the infection is being cleared.
The interpretation of an IgG antibody is more difficult. This antibody is an indicator of a past infection. The test is often not specific enough to determine if the past infection was caused by the SARS-CoV-2 virus or one of the four common coronaviruses that cause influenza-like illness.
The FDA says:
Because serology testing can yield a negative test result even if the patient is actively infected (e.g., the body has not yet developed in response to the virus) or maybe falsely positive (e.g., if the antibody indicates a past infection by a different coronavirus), this type of testing should not be used to diagnose an acute or active COVID-19 infection.
Similarly, the CDC says the following regarding antibody testing:
- If you test positive:
- A positive test result shows you have antibodies as a result of an infection with SARS-CoV-2, or possibly a related coronavirus.
- It's unclear if those antibodies can provide protection (immunity) against getting infected again. This means that we do not know at this time if antibodies make you immune to the virus.
- If you have no symptoms, you likely do not have an active infection and no additional follow-up is needed.
- It's possible you might test positive for antibodies and you might not have or have ever had symptoms of COVID-19. This is known as having an asymptomatic infection [ie you have a healthy immune system!]
- An antibody test cannot tell if you are currently sick with COVID-19.
- If you test negative
- If you test negative for antibodies, you probably did not have a previous infection. However, you could have a current infection because antibodies don't show up for 1 to 3 weeks after infection.
- Some people may take even longer to develop antibodies, and some people may not develop antibodies.
- An antibody test cannot tell if you are currently sick with COVID-19.
What? Wait!
- Doesn't the vaccine industry call the IgG a "protective antibody"?
- Isn't this the marker of immunity they assess after you've had an infection with measles or chickenpox or mumps to determine if you are immune to future infections?
- Isn't this the marker of induced immunity they are trying to achieve by administering a vaccine?
If the FDA does not know if an IgG antibody to SARS-CoV-2 after recovering from the infection is protective against a future infection, then they certainly don't know if an antibody caused by a vaccine will prevent infection either.
Doesn't this completely eliminate the theory that antibodies afford protection and antibodies from vaccines are necessary to keep you from getting sick?
Mandatory Testing – New Job Creation
Illinois U.S. Rep. Bobby L. Rush introduced the H.R. 6666 TRACE Act on May 1. On his website, Rush said ,
Until we have a vaccine to defeat this dreaded disease, contact tracing in order to understand the full breadth and depth of the spread of this virus is the only way we will be able to get out from under this.
H.R.6666 would authorize the Secretary of Health and Human Services (HHS), acting through the Director of the CDC to award grants to eligible entities to conduct diagnostic testing and then to trace and monitor the contacts of infected individuals. The contact tracers would be authorized to test people in their homes and as necessary, quarantine people in place.
Where do they intend to do this testing? Besides mobile units to test people in their homes, the bill identifies eight specific locations where the testing and contract tracing could occur: schools, health clinics, universities, churches, and "any other type of entity" the secretary of HHS wants to use.
The bill would allocate $100 billion in 2020 "and such sums as may be necessary for fiscal year 2021 and any subsequent fiscal year during which the emergency period continues."
But what are they looking for?
- Is your test supposed to be positive – saying you've been exposed and you've possibly recovered?
- Or is your test supposed to be negative , meaning, you are healthy?
- Or does a completely negative test – negative RT-PCR test and no IgG antibody mean you're susceptible to infection and you need to stay in quarantine?
The virus is rapidly mutating, which is rather typical of RNA viruses. In a study published in April 2020, researchers have discovered that the novel coronavirus has mutated into at least 30 different genetic variations. If your RT-PCR test is positive, does this identify exposure to the pandemic virus or exposure to one of the genetic variations? The same can be said about the vaccines under development: With each mutation, is the vaccine more likely to be all risk and no benefit when it reaches the market?
What You Can Do
Across the nation, police are being told to not apprehend criminals but instead, to arrest parents at playgrounds, to arrest lone surfers on public beaches, to fine ministers and congregation members sitting in their cars listening to a service on the radio, and to restrict movement by creating one-way sidewalks.
People have had enough. They are beginning to see the huge scam that has been perpetrated on the entire world over a viral infection with a global death rate of 1.4% (meaning, 1.4% of people infected with SARS-CoV-2 have a fatal outcome, while 98.6% recover). This is far fewer deaths than a severe flu season.
We're already starting to see the thrust to take our power back:
- In Virginia, people went to the beaches en mass, ignoring social distancing and the orders of the Governor to stay home.
- The central California city of Atwater has declared itself a "sanctuary city," allowing business owners and churches to open, openly defying Democratic California Gov. Gavin Newsom's coronavirus-related stay-at-home order.
- The truth about wearing masks is starting to come out and people are voting with their feet. Retired neurosurgeon, Dr. Russell Blaylock, warns that not only do face masks fail to protect healthy people from contracting an illness, but they create serious health risks to the wearer.
While they shut us down and held us hostage in our homes, they changed our society, our lives, our world.
- I am not willing to accept this is the "new normal."
- I won't submit to testing.
- I will refuse mandatory vaccination.
- I will stop wearing a mask.
- I will not be afraid of standing next to a friend or family member and will not obey the concept of "social distancing."
- I will understand that an asymptomatic carrier is a normal, healthy person and I will not buy into the fear that I might "catch something" from a normal, healthy person.
It's time for Americans to resist with non-violent civil disobedience. Be brave. Be bold. Put on the full armor of God, as found in Ephesians 6:10-20 in the Bible, to stand against the world rulers of this present darkness. With God on our side, all things are possible.
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Jul 03, 2020 | www.moonofalabama.org
Mina , Jul 3 2020 12:57 utc | 134
"The current work suggests that while the G614 variant may be more infectious, it is not more pathogenic. There is a hope that as SARS-CoV-2 infection spreads, the virus might become less pathogenic,"
i.e. that if schools had been left open, it would have spread and became less pathogenic earlier.
https://edition.cnn.com/2020/07/02/health/coronavirus-mutation-spread-study/index.html
Jun 11, 2020 | video.foxnews.com
WHO now says asymptomatic spread of coronavirus is 'very rare'
Jun. 09, 2020 - 4:06 - World Health Organization changes its tune on asymptomatic patients spreading COVID-19; reaction from Fox News medical contributor Dr. Marc Siegel.
Jun 11, 2020 | www.moonofalabama.org
Richard Steven Hack , Jun 11 2020 0:18 utc | 48
Although numerous studies have suggested people can spread the virus before they show symptoms, the WHO has largely dismissed those as anecdotal or pointed out that they were based on modelling.Babak Javid, an infectious diseases doctor at Cambridge University Hospital, says many scientists are persuaded by the studies published so far and think WHO should publish the data it is citing to explain why it believes transmission of the disease in people without symptoms is "rare".
"If you're going to make a really important statement like that, it would be good to back it up," Javid said. "I think WHO is an important organisation, but they've made a lot of statements that have been misleading."
Jun 10, 2020 | video.foxnews.com
Reaction and analysis from Fox News medical contributor Dr. Marc Siegel.
Jun 08, 2020 | www.moonofalabama.org
oldhippie , Jun 7 2020 23:59 utc | 45
PavewayIV @ 36Try doing a search on Kary Mullis, creator of the PCR process. He died last year so we can only go by past statements. He always stated that PCR was completely inappropriate and meaningless for diagnostics or for any other clinical purpose.
CDC guidance on PCR until earlier this year was that doctors do diagnosis, not laboratories. Doctors were allowed to consider PCR results as a factor, cautioned not to rely on them. In current situation PCR results are the definition of COVID.
If the test is allowed to run too many cycles any sample will test positive.
And it is never entirely certain how many cycles have elapsed, clock does not tell exactly what the RNA is up to.
May 08, 2020 | www.cnet.com
Some doctors are recommending these small, inexpensive devices to help monitor symptoms.
A pulse oximeter attaches to a finger and uses light to detect the level of oxygen in your blood.
As coronavirus testing efforts continue to ramp up and face masks are now a part of everyday life, a small diagnostic tool that clips to the tip of your finger is fast becoming a must-have gadget in the fight against the coronavirus . It's called a pulse oximeter, and it painlessly checks your blood oxygen level, which can be affected by lung diseases such as COVID-19.
The device was already starting to surge in popularity as word got around that people with the coronavirus frequently arrive at the hospital with abnormally low oxygen levels . After an op-ed piece in The New York Times recommended the use of pulse oximeters to detect a frightening condition called "silent hypoxia," sales of the devices skyrocketed . Many models are sold out or on lengthy backorder online. Same with brick-and-mortar drug stores, supermarkets and box stores.
May 06, 2020 | thenewkremlinstooge.wordpress.com
Apr 29, 2020 | www.zerohedge.com
New York State has tested over 2,000 first responders for COVID-19 antibodies.
Preliminary results:
FDNY/EMT: 17.1% positive
NYPD: 10.5% positive
Apr 28, 2020 | www.nytimes.com
... ... ...
For the past few weeks, more than 50 scientists have been working diligently to do something that the Food and Drug Administration mostly has not: Verifying that 14 coronavirus antibody tests now on the market actually deliver accurate results.
These tests are crucial to reopening the economy, but public health experts have raised urgent concerns about their quality. The new research, completed just days ago and posted online Friday, confirmed some of those fears: Of the 14 tests, only three delivered consistently reliable results . Even the best had some flaws.
The research has not been peer-reviewed and is subject to revision. But the results are already raising difficult questions about the course of the epidemic.
Surveys of residents in the Bay Area, Los Angeles and New York this week found that substantial percentages tested positive for antibodies to SARS-CoV-2, the official name of the new coronavirus. In New York City, the figure was said to be as high as 21 percent. Elsewhere, it was closer to 3 percent.
The idea that many residents in some parts of the country have already been exposed to the virus has wide implications. At the least, the finding could greatly complicate plans to reopen the economy.
Already Americans are scrambling to take antibody tests to see if they might escape lockdowns. Public health experts are wondering if those with positive results might be allowed to return to work.
But these tactics mean nothing if the test results can't be trusted.
In the new research, researchers found that only one of the tests never delivered a so-called false positive -- that is, it never mistakenly signaled antibodies in people who did not have them.
Two other tests did not deliver false-positive results 99 percent of the time. But the converse was not true. Even these three tests detected antibodies in infected people only 90 percent of the time, at best.
The false-positive metric is particularly important. The result may lead people to believe themselves immune to the virus when they are not, and to put themselves in danger by abandoning social distancing and other protective measures.
It is also the result on which scientists are most divided.
"There are multiple tests that look reasonable and promising," said Dr. Alexander Marson, an immunologist at the University of California, San Francisco, and one of the project's leaders. "That's some reason for optimism."
Dr. Marson is also an investigator in the Chan Zuckerberg Biohub, which partly funded the study.
Other scientists were less sanguine than Dr. Marson. Four of the tests produced false-positive rates ranging from 11 percent to 16 percent; many of the rest hovered around 5 percent.
Apr 28, 2020 | www.nakedcapitalism.com
By JoNel Aleccia, Senior Correspondent at Kaiser Health News, who previously reported for The Seattle Times, NBCNews.com, TODAY.com and MSNBC.com. Originally published at Kaiser Health News
After hearing for months about serious access issues involving tests that diagnose COVID-19 based on swabs from the nose or throat, Americans are being inundated with reports about promising new tests that look for signs of infection in the blood.
There are high hopes for these antibody tests, which detect proteins that form in blood as part of the body's immune response to an invading virus. Communities across the U.S. have been rolling out the results of serological surveys that examine blood samples from people who haven't been diagnosed with COVID-19 to see if they were, in fact, previously infected.
The thinking is, if there are blood markers that can detect when people have been infected, such tests should be able to tell us how widely the novel coronavirus has spread. And equally optimistic: those same antibodies could convey immunity to the disease, signaling someone is safe from reinfection and able to get back to work.
Such high hopes, however, are running smack into the roadblocks of reality.
Infectious disease experts are raising pointed questions about the reliability of the early tests and the studies that hinge on their results. And they warn that state and local governments -- as well as individuals -- should be wary of shaping policy or changing behavior based on any single report.
In the sharpest caution to date, officials with the World Health Organization on Saturday warned against plans for proposed "immunity passports," which would allow people who have recovered from the coronavirus to resume unrestricted travel and work.
"There is currently no evidence that people who have recovered from COVID-19 and have antibodies are protected from a second infection," the agency wrote in a scientific brief.
Even before the WHO weighed in, other experts were urging restraint in interpreting early results of antibody screening.
"The science is catching up," said Dr. Liise-anne Pirofski, chief of the division of infectious diseases at the Albert Einstein College of Medicine and Montefiore Health System. "Our ability to make a test at the moment is much greater than our understanding of what those antibodies we are testing for mean."
In the past few weeks, more than 180 academic centers, hospitals and private manufacturers have notified the federal Food and Drug Administration that they intend to create serology tests for COVID-19, spokesperson Stephanie Caccomo said in an email. They've been able to jump into the fray because the FDA in March relaxed regulations for developing tests as part of its emergency response to the pandemic.
But the FDA has not reviewed the vast majority of tests on the market, and their validity, particularly point-of-care blood tests that promise rapid results within minutes, isn't clear, said Dr. Michael Busch, director of the Vitalant Research Institute and a professor of laboratory medicine at the University of California-San Francisco.
"Some of them have sensitivities that are quite poor," he said. "You may even miss some infected people completely."
Other tests may flag people as positive for COVID-19 when they're not infected. That's especially true in regions of the country with little spread of the novel virus. If the prevalence of a disease is low, less than 5%, even an accurate test would yield a high number of false positive results because of the way such screening tools operate.
So when people see advertisements for finger-prick antibody tests becoming widely available at urgent care centers and medispas, they should think twice.
For one, antibody tests can't be used to diagnose the disease. Antibodies may not be present in high enough levels to be detected in the earliest days of an infection. And because there are several other known coronaviruses -- including those that cause the common cold -- people infected with those viruses could produce antibodies that cross-react with those produced in response to the new virus.
Scientists still know too little about whether antibodies to COVID-19 convey immunity that could allow people to put away masks and halt social distancing, said Dr. Mary Hayden, director of the division of clinical microbiology at Rush University Medical Center in Chicago.
Immunity to a virus is a complicated process that takes place over one to two weeks, the WHO noted. The immune system makes antibodies in response to an infection. But the body also makes T-cells that recognize and eliminate other cells infected with the virus, creating what's known as cellular immunity. Those two processes together may help a person recover and prevent reinfection. But it is not yet clear whether cellular immunity is required to bolster recovery and prevent subsequent infection with COVID-19.
"We do not know whether or not the antibodies detected are protective," Hayden told reporters last week on a call organized by the Infectious Diseases Society of America . "We recommend that people with antibodies not change their behavior in any way."
Scientists are hoping, however, that future COVID-19 studies may demonstrate immunity that could last for one or two years.
Concerns about the validity of the tests have cast a shadow on several recent reports aiming to quantify the spread of the virus in specific regions. Last week, New York Gov. Andrew Cuomo revealed the results of a serological survey that suggested that 1 in 5 New York City residents had been infected with the coronavirus. Statewide, the figure was 13.9%, according to the study of 3,000 New Yorkers in 19 counties who were recruited at grocery stores.
But the results quickly drew criticism. Dr. Demetre Daskalakis, who directs the city's disease control, warned that the tests could produce "false negative or false positive results. " Florian Krammer, a microbiology professor at the Icahn School of Medicine at Mount Sinai who designs such tests, tweeted -- and later deleted -- that the results were "BS."
"I think this is too high," he said in a later tweet. "It is possible. But a 20% plus infection rate seems too high for NYC due to a number of reasons. I would think 6-8%, maybe 10% are closer to the truth. It would be nice to know more about the test, its sensitivity and specificity and the test population."
Similarly, two serology studies in California, one in Santa Clara County and one in Los Angeles County, drew wide criticism about the recruitment of subjects and the analyses used.
In the Santa Clara study , Stanford University researchers tested 3,330 volunteers for antibodies showing exposure to COVID-19; about 1.5% were positive. They concluded that meant from 48,000 to 81,000 people were infected with the virus in the county.
"It was completely inadequate to interpret the results that 50,000 to 80,000 people were infected," Busch said.
The L.A. study, conducted by University of Southern California researchers, concluded that 2.8% to 5.6% of the county's adult population had been exposed to the coronavirus. That translates to 221,000 to 422,000 adult residents who have been infected. Critics, however, argued that the study sample was too small and that details of the methodology weren't immediately available.
Busch understands the drive to conduct such tests.
"People are asking the questions: What's the real denominator to judge the case counts and the death counts against?" he said. "People are urgently trying to get data."
Unfortunately, that data simply is not available yet, other experts said. This coronavirus has never been seen before, so the science that will inform efforts to help communities respond and recover is playing out in real time.
"The problem is that the science has not kept up with the tests," Hayden said. "Now we need to do the research to tell what the results mean."
On the positive side, most of the scientific community has pivoted to focus on finding solutions, said Pirofski, who was also on the IDSA call. "We just have to slow our roll."
"This is our first dive in trying to understand what's going on," she said. "I would say it's a start."
Google matched content |
[Jul 01, 2021] Experts -- US COVID-19 positivity rate high due to 'too sensitive' tests by Marlene Lenthang Published on Aug 30, 2020 | www.msn.com
[Dec 06, 2020] Tested 'Positive' For COVID-19- Be Sure To Ask This Question Published on Dec 06, 2020 | www.zerohedge.com
[Sep 06, 2020] Inactive fragments on virus RNA trigger false positives in most common COVID test due to way too many cycles of amplification which amplifies noise along with the signal and efffectly turns noise (inactive fragments on RNA) into signal, new study finds Published on Sep 05, 2020 | www.zerohedge.com
[Apr 28, 2020] Consumer Beware Coronavirus Antibody Tests Are Still A Work In Progress Published on Apr 28, 2020 | www.nakedcapitalism.com
COVID-19 testing- What can you expect from a test now
"(A PCR test) detects viral genetic code that does not exist in the human body otherwise," Cioe-Pena explained. "They're sensitive to the point where it will even detect fragments," which can mean that someone who was sick but then recovered could still test positive, he said.
How COVID-19 test works- Know the basics - World – Gulf News
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Last modified: July 03, 2021
I'd only add that the virus was clearly "circulating" well before the Wuhan outbreak in late December 2019.
We don't know how many people contracted the virus in November, December 2019 and January and February 2020. But this number is certainly much larger than we have been told ... And plenty of government officials and public health authorities MUST know this.
I agree with this story. I do believe there will be a cycle count decrease corresponding to the mask mandate and the vaccine rollout. The entire Covid-19 from top to bottom is a political system having nothing to do with medical science.
I'm surprised Fauci admitted to high PCR enough counts leading to zero accuracy like here: https://twitter.com/jimgris/status/1326518250386063361
Err... Any chance now the WHO consider and approve the RT-PCR peer review published by 22 world-renowned scientists last November and revealing no less than 10 major scientific flaws in the Corman-Drosten RT-PCR test recommended in January 2020 by medical journal Eurosurveillance? 10 major flaws that make that PCR test totally useless for the diagnostic of covid.
To the peer review is also joined a letter with a request to Eurosurveillance to retract that article and recommendation of January 2020.
The whole pandemic was based on that PCR testing. And Covid disappeared in China only when they decided to stop testing. A corollary is that it magically 'reappears' whenever they start testing again...Go figure.
https://cormandrostenreview.com/report/